Reducing intake of dietary fat prevents prostate cancer in mice

May 15, 2008

Finding may lead to new strategies to fight disease in men

Scientists with UCLA's Jonsson Cancer Center and the Department of Urology have showed that lowering intake of the type of fat common in a Western diet helps prevent prostate cancer in mice, the first finding of its kind in a mouse model that closely mimics human cancer, researchers said.

The study, which appears in the April 15, 2008 issue of the journal Cancer Research, focused on fat from corn oil, which is made up primarily of omega-6 fatty acids, or the polyunsaturated fat commonly found in the Western diet. Omega-6 fats are found in high levels in baked and fried goods, said William Aronson, a Jonsson Cancer Center researcher and the study's senior author.

Researchers fed one group of mice a diet with about 40 percent of calories coming from fat, a percentage typical in men eating a Western diet. The other group received 12 percent of their calories from fat, a figure considered to be a very low fat diet. Researchers found there was a 27 percent reduced incidence of prostate cancer in the low-fat diet group. Aronson also studied cells in the prostate that were precancerous, or would soon become cancer, and found that the cells in the mice eating the low-fat diet were growing much more slowly than those in the high-fat group.

Previous studies in Aronson's lab showed that a low-fat diet slowed the growth of aggressive human prostate cancers in mice and helped the mice live longer. However, whether such a diet could prevent prostate cancer was unknown.

"We didn't know what to expect in terms of the role of reducing dietary fat in preventing prostate cancer," said Aronson, a professor of urology. "We think this is an important finding and we are presently performing further studies in animal models and conducting clinical trials in men."

Using a novel mouse model that develops cancer within the prostate over a period of six to nine months, Aronson and his team were able to study cancer incidence and cell growth. The mice were assigned to a dietary fat group at three weeks of age, when they first started ingesting food. The prostates and prostate cells were studied at seven months.

During the growth phase when the precancerous lesions develop, called PIN or prostate intraepithelial neoplasia, Aronson found that mice on the low-fat diet had higher levels of a protein in their bloodstreams that binds to insulin like growth factor, which spurs prostate cancer growth. Aronson believes that lowering dietary fat and increasing levels of the binding protein slows prostate cancer development by cutting off the growth factor that allows prostate cancer to thrive.

"A low-fat, high-fiber diet combined with weight loss and exercise is well known to be healthy in terms of heart disease and is known to reduce the risk of heart attacks and strokes, so that would be a healthy choice to make," Aronson said. "Whether or not it will prevent prostate cancer in humans remains to be seen."

Aronson is now conducting a short term study in men who are randomly assigned to a Western diet higher in polyunsaturated fat or a low-fat diet with fish oil supplements. The next step is to see how these diets affect malignant and benign human prostate tissue, Aronson said.

"We're looking at specific markers and growth factors in human tissue known to be important for development and progression of prostate cancer," he said. "It's this work we hope will lead to longer term prevention strategies incorporating dietary changes."

University of California - Los Angeles

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