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Green tea compounds beat OSA-related brain deficits
May 15, 2008Chemicals found in green tea may be able to stave off the cognitive deficits that occur with obstructive sleep apnea (OSA), according to a new study published in the second issue for May of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
Researchers examined the effects green tea polyphenols (GTP), administered through drinking water, on rats who were intermittently deprived of oxygen during 12-hour "night" cycles, mimicking the intermittent hypoxia (IH) that humans with OSA experience.
People with OSA have been reported to have increased markers of oxidative stress and exhibit architectural changes in their brain tissue in areas involved in learning and memory. Chronic IH in rats produce similar neurological deficit patterns.
"OSA has been increasingly recognized as a serious and frequent health condition with potential long-term morbidities that include learning and psychological disabilities [-]," wrote David Gozal, M.D., professor and director of Kosair Children's Hospital Research Institute at the University of Louisville, lead author of the article. "A growing body of evidence suggests that the adverse neurobehavioral consequences imposed by IH stem, at least in part, from oxidative stress and inflammatory signaling cascades."
GTPs are known to possess anti-oxidant properties, acting as a free radical scavengers, and research has shown that the compounds may reduce the risk of a variety of different diseases.
"Recent studies have demonstrated the neuroprotective activity of GTP in animal models of neurodegenerative conditions such as Parkinson's and Alzheimer's disease," wrote Dr. Gozal.
In this study, the researchers divided 106 male rats into two groups that underwent intermittent oxygen depletion during the 12-hour "night" cycle for 14 days. One group received drinking water treated with GTP; the other received plain drinking water.
They were then tested for markers of inflammation and oxidative stress, as well as for performance in spatial learning and memory tasks-namely a water "maze" in which the rat had to memorize the location of a hidden platform.
The IH-rats that received the green tea-treated water performed significantly better in a water maze than the rats that drank plain water. "GTP-treated rats exposed to IH displayed significantly greater spatial bias for the previous hidden platform position, indicating that GTPs are capable of attenuating IH-induced spatial learning deficits," wrote Dr. Gozal, adding that GTPs "may represent a potential interventional strategy for patients" with sleep-disordered breathing.
American Thoracic Society
"OSA has been increasingly recognized as a serious and frequent health condition with potential long-term morbidities that include learning and psychological disabilities [-]," wrote David Gozal, M.D., professor and director of Kosair Children's Hospital Research Institute at the University of Louisville, lead author of the article. "A growing body of evidence suggests that the adverse neurobehavioral consequences imposed by IH stem, at least in part, from oxidative stress and inflammatory signaling cascades."
GTPs are known to possess anti-oxidant properties, acting as a free radical scavengers, and research has shown that the compounds may reduce the risk of a variety of different diseases.
"Recent studies have demonstrated the neuroprotective activity of GTP in animal models of neurodegenerative conditions such as Parkinson's and Alzheimer's disease," wrote Dr. Gozal.
In this study, the researchers divided 106 male rats into two groups that underwent intermittent oxygen depletion during the 12-hour "night" cycle for 14 days. One group received drinking water treated with GTP; the other received plain drinking water.
They were then tested for markers of inflammation and oxidative stress, as well as for performance in spatial learning and memory tasks-namely a water "maze" in which the rat had to memorize the location of a hidden platform.
The IH-rats that received the green tea-treated water performed significantly better in a water maze than the rats that drank plain water. "GTP-treated rats exposed to IH displayed significantly greater spatial bias for the previous hidden platform position, indicating that GTPs are capable of attenuating IH-induced spatial learning deficits," wrote Dr. Gozal, adding that GTPs "may represent a potential interventional strategy for patients" with sleep-disordered breathing.
American Thoracic Society
Green Tea Current Events and Green Tea News RSSAn atomic-level look at an HIV accomplice
Since the discovery in 2007 that a component of human semen called SEVI boosts infectivity of the virus that causes AIDS, researchers have been trying to learn more about SEVI and how it works, in hopes of thwarting its infection-promoting activity.
Antifibrotic effects of green tea
Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis.
Does green tea prevent cancer? Evidence continues to brew, but questions remain
Although scientists are reluctant to officially endorse green tea as a cancer prevention method, evidence continues to grow about its protective effects, including results of a new study published in Cancer Prevention Research, a journal of the American Association for Cancer Research, which suggests some reduction in oral cancer.
Green tea shows promise as chemoprevention agent for oral cancer, M. D. Anderson study finds
Green tea extract has shown promise as cancer prevention agent for oral cancer in patients with a pre-malignant condition known as oral leukoplakia, according to researchers at The University of Texas M. D. Anderson Cancer Center.
New evidence that green tea may help improve bone health
Researchers in Hong Kong are reporting new evidence that green tea - one of the most popular beverages consumed worldwide and now available as a dietary supplement - may help improve bone health.
Green tea component may help preserve stored platelets, tissues
In two separate studies, a major component in green tea, epigallocatechin-3-O-gallate (EGCG), has been found to help prolong the preservation of both stored blood platelets and cryopreserved skin tissues.
Baby boomers' boon? LED light and green tea cream to smooth facial wrinkles
Scientists in Germany are reporting a major improvement in their potential new treatment for facial wrinkles that could emerge as an alternative to Botox and cosmetic surgery.
Model backs green tea and lemon claim, lessens need to test animals
An animal study at Purdue University has shown that adding ascorbic acid and sugar to green tea can help the body absorb helpful compounds and also demonstrates the effectiveness of a model that could reduce the number of animals needed for these types of studies.
Sensitizing tumor response to cancer therapy
Two forms of skin and brain cancer respond very poorly to chemotherapy and radiation: melanoma and glioblastoma multiforme brain cancer.
Green tea may affect prostate cancer progression
According to results of a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research, men with prostate cancer who consumed the active compounds in green tea demonstrated a significant reduction in serum markers predictive of prostate cancer progression.
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