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Treatment of obstructive sleep apnea with CPAP may lower blood pressure
May 19, 2008Treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) may also lower blood pressure among hypertensive adults, according to researchers in Spain, who will present his findings at the American Thoracic Society's 2008 International Conference in Toronto on Sunday, May 18.
The study included 394 consecutive patients with high blood pressure and non-sleepy OSA-those with mild enough OSA that their daytime alertness was unaffected. They were randomized to receive either CPAP or no treatment.
Blood pressure was measured at three-, six- and 12-month follow-ups after their baseline evaluation. The researchers found that, on average, patients who used the CPAP machine experienced an average 2mmHg drop in both systolic and diastolic blood pressure at the end of the year when compared to patients who did not use the CPAP machine.
"This is the largest study trial in the field and it shows hat CPAP has an effect on cardiovascular outcomes regardless of symptoms," said Ferran E. Barbé, M.D., who headed the research. "This suggests that CPAP can not only be used to treat the symptoms of sleep apnea (daytime sleepiness), but also to reduce cardiovascular risk in apneic patients."
The patients for whom the effect was most produced used the CPAP machine for more than five hours a night. "The mechanism by which CPAP is able to effect a drop in blood pressure is complex and it is mainly related to a reduction in sympathetic tone, oxidative stress," explained Dr. Barbé.
Although researchers do not yet know whether CPAP should be recommended for all OSA patients with high blood pressure and without daytime sleepiness, barring contraindications, the results point to the need for further study of the cardiovascular benefits of CPAP in OSA patients.
"In the future, we would like to know the effects of CPAP treatment on other cardiovascular outcomes such as stroke, myocardial infarction or heart failure," said Dr. Barbé.
American Thoracic Society
"This is the largest study trial in the field and it shows hat CPAP has an effect on cardiovascular outcomes regardless of symptoms," said Ferran E. Barbé, M.D., who headed the research. "This suggests that CPAP can not only be used to treat the symptoms of sleep apnea (daytime sleepiness), but also to reduce cardiovascular risk in apneic patients."
The patients for whom the effect was most produced used the CPAP machine for more than five hours a night. "The mechanism by which CPAP is able to effect a drop in blood pressure is complex and it is mainly related to a reduction in sympathetic tone, oxidative stress," explained Dr. Barbé.
Although researchers do not yet know whether CPAP should be recommended for all OSA patients with high blood pressure and without daytime sleepiness, barring contraindications, the results point to the need for further study of the cardiovascular benefits of CPAP in OSA patients.
"In the future, we would like to know the effects of CPAP treatment on other cardiovascular outcomes such as stroke, myocardial infarction or heart failure," said Dr. Barbé.
American Thoracic Society
CPAP Current Events and CPAP News RSSSurgery is an option for some patients hoping to get a good night's rest
According to research recently published by an Oregon Health & Science University scientist, a form of surgery called uvopalatopharyngoplasty is effective for treating certain patients who suffer from sleep apnea, one of the most common sleep disorders.
Severe sleep apnea tied to increased risk of death
Moderate to severe obstructive sleep apnea is associated with an increased risk of death from any cause in middle-aged adults, especially men, according to new results from a landmark study supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH).
Benefits from upper airway surgery for sleep apnea found to equal CPAP
Adults who struggle with CPAP treatment for obstructive sleep apnea (OSA) should be considered candidates for reconstructive surgery on the upper airway, because it holds the same quality-of-life (QOL) benefits but with more permanence.
CPAP treatment linked to lower mortality in stroke patients with OSA
Stroke patients with obstructive sleep apnea (OSA) who undergo treatment with continuous positive airway pressure (CPAP) following their stroke may substantially reduce their risk of death.
Complaints of fatigue and tiredness in people with OSA improve with CPAP treatment
A study in the June 15 issue of the Journal of Clinical Sleep Medicine shows that the complaints of fatigue and tiredness in patients with obstructive sleep apnea (OSA) improved significantly with good adherence to continuous positive airway pressure (CPAP) therapy, suggesting that - like the symptom of excessive daytime sleepiness - these complaints are important symptoms of OSA.
Obstructive sleep apnea patients have increased occurrences of parasomnia symptoms
Patients suffering from obstructive sleep apnea (OSA) have an increased prevalence of parasomnia symptoms compared with the prevalence rates of individual parasomnias.
Men who work with their female partners more likely to adhere to CPAP therapy
Men who work with their female partners while receiving continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA) are more likely to adhere to their treatment.
Problem solving and coping styles related to CPAP adherence
According to a research abstract that will be presented on Monday, June 8, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, active problem solving strategies are associated with successful use of continuous positive airway pressure (CPAP) therapy for the treatment of obstructive sleep apnea (OSA).
Obstructive sleep apnea, retinopathy linked in diabetes
The eyes may be the window into the soul, but they may also contain important medical information.
2-week course of sleep aid increases CPAP adherence in OSA patients at 6 months
New research suggests that patients newly diagnosed with obstructive sleep apnea (OSA) who use a short-course of the sleep aid, eszopiclone, when beginning continuous positive airway pressure (CPAP) therapy, are more adherent with therapy in six months.
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