 |
|
Possible biological explanation for C-Section-linked allergies and asthma found
May 21, 2008Scientists believe they may have identified a biological explanation for the link between cesarean-section delivery and risk of allergy and asthma in childhood. They will present their findings at the American Thoracic Society's 2008 International Conference in Toronto on Tuesday, May 20.
Several studies have shown immunological differences between children with and without allergy at the time of birth. For example, increased cord blood levels of IL-13, a Th2 type cytokine, have been positively associated with allergy among children with a family history of allergy
Regulatory T cells are a subgroup of T lymphocytes with immune suppressive properties on effector T cells, which in turn regulate cytokine secretion and the development and function of the immune system. Evidence suggests that CD4+CD25+ T regulatory (Treg) cells in those with asthma or allergy may be functionally impaired.
"Our research looked at the effect of cesarean-section versus vaginal delivery in newborns to determine whether cesarean-section was associated with reduced regulatory T-cell function," said lead researcher Ngoc Ly, M.D., M.P.H., who is assistant professor of pediatrics at the University of California, San Francisco.
In a previous study Dr. Ly and colleagues demonstrated an association between cesarean section and increased neonatal secretion of IL-13. In this latest study, the researchers measured the expression and function of specific regulatory T-cells in the cord blood of 50 newborns born by cesarean section, and 68 delivered vaginally, all of whose have at least one parent with allergies and/or asthma. They found that babies born by cesarean section showed a reduction in the suppressive function of their regulatory T-cells. There was a trend for lower level of TGF-ƒ", a cytokine secreted by tregs, and higher level of IL-4 and IL-13 among children born by c-section as compared to children born by vaginal delivery.
"This finding is exciting because it suggests that the mode of delivery may be an important factor influencing immune system development in the neonate," said Dr. Ly, who postulated that the stress and process of labor itself or exposure to specific microbes through the birth canal in vaginal as compared to c-section delivery may influence neonatal immune responses.
"These findings are preliminary and further work is needed to explore potential mechanisms for the association between mode of delivery and neonatal immune responses," she/he" explained. "However, this finding provided a potential immunologic basis for previous reports of the association among cesarean section, elevated IL-13 and allergy and asthma."
American Thoracic Society
"Our research looked at the effect of cesarean-section versus vaginal delivery in newborns to determine whether cesarean-section was associated with reduced regulatory T-cell function," said lead researcher Ngoc Ly, M.D., M.P.H., who is assistant professor of pediatrics at the University of California, San Francisco.
In a previous study Dr. Ly and colleagues demonstrated an association between cesarean section and increased neonatal secretion of IL-13. In this latest study, the researchers measured the expression and function of specific regulatory T-cells in the cord blood of 50 newborns born by cesarean section, and 68 delivered vaginally, all of whose have at least one parent with allergies and/or asthma. They found that babies born by cesarean section showed a reduction in the suppressive function of their regulatory T-cells. There was a trend for lower level of TGF-ƒ", a cytokine secreted by tregs, and higher level of IL-4 and IL-13 among children born by c-section as compared to children born by vaginal delivery.
"This finding is exciting because it suggests that the mode of delivery may be an important factor influencing immune system development in the neonate," said Dr. Ly, who postulated that the stress and process of labor itself or exposure to specific microbes through the birth canal in vaginal as compared to c-section delivery may influence neonatal immune responses.
"These findings are preliminary and further work is needed to explore potential mechanisms for the association between mode of delivery and neonatal immune responses," she/he" explained. "However, this finding provided a potential immunologic basis for previous reports of the association among cesarean section, elevated IL-13 and allergy and asthma."
American Thoracic Society
Allergy Current Events and Allergy News RSSNew findings suggest strategy to help generate HIV-neutralizing antibodies
New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Sweet -- sugared polymer a new weapon against allergies and asthma
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks.
UAB Researchers Discover Antibody Receptor Identity, Propose Renaming Immune-System Gene
Researchers at the University of Alabama at Birmingham (UAB) have uncovered the genetic identity of a cellular receptor for the immune system's first-response antibody, a discovery that sheds new light on infection control and immune disorders.
Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
At the annual meeting of the Sexual Medicine Society of North America (SMSNA), Inc. in San Diego, Sciele Pharma, Inc., a Shionogi Company and Plethora Solutions Limited, a wholly owned subsidiary of Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE)., today presented data from its second positive pivotal study of PSD502 for the treatment of premature ejaculation (PE).
Small nanoparticles bring big improvement to medical imaging
If you're watching the complex processes in a living cell, it is easy to miss something important-especially if you are watching changes that take a long time to unfold and require high-spatial-resolution imaging.
Women with asthma feel worse
Women with asthma are more anxious, find it harder to sleep and are more tired during the day than their male counterparts, but nevertheless tend to be better at following their treatment.
Key player identified in cascade that leads to hypertension-related kidney damage
A key player in a cascade that likely begins with stress and leads to high blood pressure and kidney damage has been identified by researchers who say the finding may lead to better ways to control both.
Initial Results Show Pregnant Women Mount Strong Immune Response To One Dose of 2009 H1N1 Flu Vaccine
Healthy pregnant women mount a robust immune response following just one dose of 2009 H1N1 influenza vaccine, according to initial results from an ongoing clinical trial sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.
Global challenges and opportunities in fighting HIV/AIDS and neglected diseases
Responding to the HIV/AIDS pandemic and tackling so-called neglected tropical diseases are the focus of the November/December 2009 edition of Health Affairs.
Progress made on group B streptococcus vaccine
Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have completed a Phase II clinical study that indicates a vaccine to prevent Group B Streptococcus (GBS) infection is possible.
More Allergy Current Events and Allergy News Articles
 |
Allergies: Disease in Disguise : How to Heal Your Allergic Condition Permanently and Naturally by Carolee Bateson-Koch (Author) |
 |
Aller-Ease Cotton Allergen Barrier Standard Pillow Cover, Set of 2 by Aller-Ease Everyone is exposed to allergens that inhabit pillows and mattresses. Caused by dust mites, mold, or pollen, these microscopic irritants can aggravate allergies and asthma symptoms. The simplest and most cost effective solution is the use of bedding fabrics that prevent these particles from entering and/or exiting your bedding. Aller-Ease products are constructed from fabrics that are proven effective at blocking common allergens. |
 |
Zyrtec Allergy Relief (10 mg), 45-Count Tablets by Zyrtec ZYRTEC (cetirizine HCl) is a prescription medicine that treats both indoor and outdoor allergy symptoms. And it also treats itching due to chronic hives. Studies show that 1 dose of ZYRTEC works for a full 24 hours. ZYRTEC is also great for the whole family. ZYRTEC is approved to treat indoor and outdoor allergy symptoms in adults and children as young as 2 years old. And it's also approved to treat indoor allergy symptoms in infants as young as 6 months. It's easy to recognize ZYRTEC. ZYRTEC tablets are white in color. And they have the name ZYRTEC engraved on them. ZYRTEC chewable tablets are purple in color. They also have the ZYRTEC name engraved on them. Another formulation is ZYRTEC syrup, which is a clear liquid with a banana-grape flavor. |
 |
Middleton's Allergy: Principles and Practice: Expert Consult: Online and Print, 2-Volume Set (Allergy (Middleton)) by N. Franklin Adkinson Jr. MD (Editor), William W. Busse MD (Editor), Bruce S. Bochner MD (Editor), Stephen T. Holgate MD DSc FRCP FRCPE MRC (Editor), F. Estelle R. Simons MD FRCPC (Editor), Robert F. Lemanske Jr. MD (Editor) This best-selling resource has a worldwide reputation as the leader in its field. Focusing on human immunology and biology, while also reporting on scientific experimentation and advancement, it provides comprehensive coverage of state-of-the-art basic science as well as authoritative guidance on the practical aspects of day-to-day diagnosis and management. This new edition includes 700 full-color illustrations and a new, more accessible format to make finding information a snap for the busy practitioner. And this Expert Consult Edition offers online access to the complete contents of the 2-volume set, fully searchable, and much more. Includes a glossary of allergy and immunology for quick and easy reference. Contains keypoints and clinical pearls highlighted to find important... |
 |
Allergy -Shield s TM Luxurious Down Alternative Comforter, Full/Queen by Natural Comfort All our Allergy -Shields TM products are machine washable & Dryable. The allergen barrier comforter is filled with 100% luxurious down alternative fiber that is almost indistinguishable from the finest down filling. Twin Size 64"x88" 35 OZ filled Weight, Full/Queen 92"x94" 46 OZ; Eastern King 102"x90" 52 OZ filled weight; California King 104"x94" 59 OZ filled weight |
 |
Allergy and Asthma: Practical Diagnosis and Management (LANGE Clinical Medicine) by Massoud Mahmoudi (Author) Clear, authoritative guidance for your day-to-day allergy and asthma practice Allergy and Asthma: Practical Diagnosis and Management is a concise guide that puts the most salient insights in allergy medicine right at your fingertips. Written by a leading allergy clinician, along with more than 40 nationally recognized expert contributors, this resource is perfect for front-line general practitioners, especially primary care physicians and allied health care providers. Inside, you'll find the most clinically relevant information on the pathophysiology, diagnosis, treatment, and prevention of all major allergic disorders. Features Need-to-know coverage that spans the entire scope of adult allergy and asthma--geared for real world medical practice ... |
 |
Diphenhydramine HCI 25 Mg Allergy Medicine and Antihistamine Compare to Active Ingredient of Benadryl® Allergy Generic - 400 Tablets by Sam's West, Inc. Temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose, sneezing, itchy, watery eyes, itching of the nose or throat. Temporarily relieves these symptoms due to the common cold: runny nose, sneezing. |
 |
Honeywell HHT-011 Compact Air Purifier with Permanent HEPA Filter by Honeywell Honeywell Permanent HEPA-Type Tabletop Air Purifier is 99% efficient at reducing airborne particles such as dust, tobacco smoke, pollen, cat dander & mold spores from the air that passes through the filter. |
 |
The Allergy and Asthma Cure: A Complete 8-Step Nutritional Program by Fred Pescatore M.D. (Author) Free yourself of allergies and asthma once and for all with Dr. Pescatore's breakthrough program " Dr. Fred Pescatore's The Allergy and Asthma Cure reveals a unique and revolutionary understanding of the underlying conditions of allergy and asthma-from food triggers to the environment to nutritional deficiencies. His integrative program of both alternative and traditional treatments can dramatically improve health and vitality, safely and soundly. This book will have a prominent place in my library and I highly recommend it! " -Ann Louise Gittleman, Ph.D., C.N.S., author of the bestselling The Fat Flush Plan "Conventional medicine has largely shrugged its shoulders in confusion about the causes of allergies and asthma in millions of people. In this... |
 |
Aller-Ease Classic Allergen Barrier Standard Pillow Cover, Set of 2 by Aller-Ease Everyone is exposed to allergens that inhabit pillows and mattresses. Caused by dust mites, mold, or pollen, these microscopic irritants can aggravate allergies and asthma symptoms. The simplest and most cost effective solution is the use of bedding fabrics that prevent these particles from entering and/or exiting your bedding. Aller-Ease products are constructed from fabrics that are proven effective at blocking common allergens. |
| © 2009 BrightSurf.com |