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How to increase the chances of remaining virus free Pakistani patients with HCV?
May 21, 2008Hepatitis C is a health care problem all over the world, with 130 million patients infected the world over. The treatment is expensive and has variable results according to the genotype of the infecting virus. The first land mark in treatment is the virus clearance at the end of the treatment called End Treatment Response (ETR), but many of the patients achieving the ETR have a relapse within the next six months. Thus, the goal of treatment is to have persistent virus clearance until six months after completing the treatment. This is called Sustained Virological Response (SVR). It is difficult to predict the SVR in patients receiving ongoing therapy.
A team of doctors, led by Dr. Bader Faiyaz Zuberi at Dow University of Health Sciences, Pakistan, conducted a study and their article will be published on April 14, 2008 in the World Journal of Gastroenterology. In this article they show that in patients with genotype-3 HCV who achieve virus clearance in the first four weeks of therapy, called Rapid Virological Response (RVR) with standard interferon, there is a high probability of achieving the SVR. They also show that patients with initial high levels of ALT were also more likely to attain RVR.
The study will help in selection and prediction of response in patients with Hepatitis C being treated with standard interferon. Pegylated interferon is very expensive and is not within the reach of most patients in developing countries.
World Journal of Gastroenterology
World Journal of Gastroenterology
Hepatitis Current Events and Hepatitis News RSSRNA molecules, delivery system improve vaccine responses, effectiveness
A novel delivery system that could lead to more efficient and more disease-specific vaccines against infectious diseases has been developed by biomedical engineers at The University of Texas at Austin.
Vitamin D deficiency common in patients with IBD, chronic liver disease
New research presented at the 73rd Annual Scientific Meeting of the American College of Gastroenterology in Orlando found patients with inflammatory bowel disease or chronic liver disease were at increased risk of developing Vitamin D deficiencies. Two separate studies highlight the importance of regular Vitamin D checkups in the evaluation of patients with certain digestive diseases.
Hepatitis B exposure may increase risk for pancreatic cancer
In a first-of-its-kind finding, researchers at The University of Texas M. D. Anderson Cancer Center have discovered that exposure to the hepatitis B virus (HBV) may increase the risk of pancreatic cancer.
Study finds association between hepatitis B and pancreatic cancer
A new study has shown that evidence of past hepatitis B infection was twice as common in people with pancreatic cancer than in healthy controls. This study is the first to report an association between past exposure to the hepatitis B virus and pancreatic cancer, but researchers cautioned that more studies are necessary to evaluate the nature of the link.
Existing anti-obesity drugs may be effective against flu, hepatitis and HIV
Viruses dramatically increase cellular metabolism, and existing anti-obesity drugs may represent a new way to block these metabolic changes and inhibit viral infection, according to a study published today in the journal Nature Biotechnology.
Majority of children vaccinated against hepatitis B not at increased risk of MS
The majority of children vaccinated against hepatitis B are not at an increased risk of developing multiple sclerosis (MS).
How to select anti-hepatitis B virus agents for drug-resistance patients?
HBV infection may lead to acute liver disease, chronic active hepatitis, liver cirrhosis, and hepatocellular carcinoma. Over 350 million people worldwide are estimated to be infected chronically by HBV and are therefore at risk of liver failure, cirrhosis, or hepatocellular carcinoma.
The natural history of 'healthy-HCV carriers'
A normal liver is observed in about 10% of HCV infected patients and the natural history of theses so-called "healthy-HCV carriers" is not fully defined.
The prevalence of hepatitis B virus infection in inflammatory bowel disease patients
Patients with IBD have high risk of infection by hepatitis viruses B or C because during the course of their disease, they need blood transfusions, and sometimes surgical and endoscopic procedures for diagnosis and treatment.
Is the intestinal mucosa barrier malfunction involved in non-alcoholic steatohepatitis?
The pathogenesis of NASH remains unclear. Nowadays, lipid metabolism abnormality, insulin resistance and oxidative stress and lipid peroxidation reaction are thought to place an important role in the pathogenesis of NASH.
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