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New method identifies rat poison in humans
May 28, 2008Researchers at the Norwegian Institute of Public Health (NIPH) have developed a method to identify bromadiolone poisoning in humans. Bromadiolone is a rat poison that can be purchased freely in shops. A number of cases have been reported internationally where people have been poisoned, with a mortality rate of 20 percent.
Blood-thinning substances have been used for many years as rodenticides. Warfarin was previously used but due to resistance development, the so-called super-warfarins were introduced. These substances are 100 times as potent as warfarin.
A commonly used super-warfarin is bromadiolone (sold as the brand name Temus in Norway). Few laboratories have been able to prove the presence of bromadiolone in human samples and little is known what happens to the substance in the human body.
Now researchers at the NIPH have developed an analysis method to spot the presence of bromadiolone. The cause of serious bleeding disturbances in a female patient was investigated during a recent poisoning case. It appeared that the woman had been exposed to blood-thinning substances. Blood samples uncovered that she had been repeatedly exposed to bromadiolone.
The researchers discovered that bromadiolone is present in blood for a much shorter time than expected. The concentration of bromadiolone is higher in blood plasma than in whole blood, which is important to note when samples in different media are interpreted. After storage of the blood samples in the freezer at -20 degrees Celsius, followed by thawing for reanalysis, the concentration of bromadiolone fell over time.
In order to treat bleeding disorders, the cause of the patient's condition must be identified as soon as possible. When poisoning with blood-thinning substances is suspected, an analysis method that can identify the superwarfarin bromadiolone, plus other superwarfarins and blood-thinning substances, is now available.
Norwegian Institute of Public Health
Now researchers at the NIPH have developed an analysis method to spot the presence of bromadiolone. The cause of serious bleeding disturbances in a female patient was investigated during a recent poisoning case. It appeared that the woman had been exposed to blood-thinning substances. Blood samples uncovered that she had been repeatedly exposed to bromadiolone.
The researchers discovered that bromadiolone is present in blood for a much shorter time than expected. The concentration of bromadiolone is higher in blood plasma than in whole blood, which is important to note when samples in different media are interpreted. After storage of the blood samples in the freezer at -20 degrees Celsius, followed by thawing for reanalysis, the concentration of bromadiolone fell over time.
In order to treat bleeding disorders, the cause of the patient's condition must be identified as soon as possible. When poisoning with blood-thinning substances is suspected, an analysis method that can identify the superwarfarin bromadiolone, plus other superwarfarins and blood-thinning substances, is now available.
Norwegian Institute of Public Health
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12 each: Victor Mouse Bait Blocks (M838) by Woodstream Corp. Kills Norway rats, roof rats, house mice, and Warfarin-resistant Norway rats. Norway rats and house mice may consume a lethal dose in one feeding with first dead rats appearing four or five days after treatment begins. Hazardous to humans and domestic ani mals. Contains (8) 1-ounce blocks. |
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4 each: Tomcat Ultra Block Bait (31239) by Motomco Ltd Sold as 4 UNITS at $5.53 per unit. (1 unit = each.) Eight 1 oz. block bait. Reliable all-weather formula for use indoors and outdoors. Multiple gnawing edges for enhanced acceptance. Use alone or in Tomcat bait stations. Can kill in one feeding. Most palatable bait-16 human food grade ingredients. Active ingredient- Bromadiolone. Tomcat FSI 2007-contact Tomcat for further details. Boxed. Manufacturer number: 31239. SKU #: 7192651. Country of origin: (TBA). Distributed by Motomco Ltd. |
![Study on the fluorescence characteristics of bromadiolone in aqueous and organized media and application in analysis [An article from: Chemosphere]](http://ecx.images-amazon.com/images/I/51M6G4MFGFL._SL160_.jpg) |
Study on the fluorescence characteristics of bromadiolone in aqueous and organized media and application in analysis [An article from: Chemosphere] by D. Subbiah (Author), S. Kala (Author), A.K. Mishra (Author) This digital document is a journal article from Chemosphere, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: The fluorescence spectroscopic behavior of bromadiolone (anticoagulant rodenticide), a substituted 4-hydroxycoumarin derivative, was investigated in water and in organized media like micelles and cyclodextrins. A detailed study on various photophysical parameters like fluorescence intensity (I"F), quantum yield (@f), lifetime (@t) and steady state fluorescence anisotropy (r) of bromadiolone in aqueous and in organized media was carried out. Bromadiolone in aqueous solution was observed to be in an aggregated state, thereby... |
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