Low HDL cholesterol from gene variation not associated with increased risk of ischemic heart diseaseJune 04, 2008Lower levels of high-density lipoprotein (HDL) cholesterol due to a gene mutation is not associated with an increased risk of ischemic heart disease, according to a study in the June 4 issue of JAMA. Numerous studies have indicated that a low plasma level of HDL cholesterol (the "good" cholesterol) is associated with an increased risk of ischemic heart disease (IHD), according to background information in the article. However, whether HDL cholesterol is a primary factor in the development of IHD is not clear, in part because of other factors related to low HDL cholesterol levels, such as plasma triglycerides, which may contribute independently to increases in cardiovascular events. "- studies of genetic disorders that lower HDL cholesterol without increases in plasma triglycerides and remnant lipoproteins provide an ideal system in which to assess the consequences of isolated, lifelong low HDL cholesterol levels," the authors write. Ruth Frikke-Schmidt, M.D., Ph.D., of the University of Copenhagen, Denmark, and colleagues examined whether mutations in the gene ABCA1, which genetically reduce HDL cholesterol levels but do not increase plasma triglyceride levels, are associated with an increased risk of IHD. Three studies were used: the Copenhagen City Heart Study (CCHS), a 31-year general population study (n = 9,022; 28 heterozygotes [a person possessing two different forms of a particular gene, one inherited from each parent]); the Copenhagen General Population Study (CGPS), (n = 31,241; 76 heterozygotes); and the Copenhagen Ischemic Heart Disease Study (CIHDS), (n = 16,623; 44 heterozygotes). Certain data in all three studies were collected during the period of January 1976 through July 2007, with researchers analyzing data on HDL cholesterol levels and the association between IHD and HDL cholesterol and genotype. The researchers found that heterozygotes vs. noncarriers for 4 ABCA1 mutations (P1065S, G1216V, N1800H, R2144X) had HDL cholesterol levels of 41 mg/dL vs. 58 mg/dL, corresponding to a reduction in HDL cholesterol of 17 mg/dL. A 17 mg/dL lower HDL cholesterol level in the CCHS was associated with a 70 percent higher risk for IHD. However, for IHD in heterozygotes vs. noncarriers, the risk was 33 percent lower in the CCHS; 18 percent lower in the CGPS; and 14 percent lower in the CIHDS. When the studies were combined (n = 41,961; 6,666 cases; 109 heterozygotes), there was no association between heterozygotes and a higher risk of IHD. "The principal finding of this study is that heterozygosity for loss-of-function mutations in ABCA1 associated with substantial, lifelong lowering of plasma levels of HDL cholesterol, but not with corresponding higher levels of plasma triglycerides or atherogenic [capable of producing a type of plaque in arteries] remnant lipoproteins, did not predict an increased risk of IHD," the authors write. JAMA and Archives Journals |
|||||||||||||||||||||
| Related Hdl Cholesterol Current Events and Hdl Cholesterol News Articles Night Beat, Overtime and a Disrupted Sleep Pattern Can Harm Officers' Health A police officer who works the night shift, typically from 8 p.m. to 4 a.m., already is at a disadvantage when it comes to getting a good "night's" sleep. oo much selenium can increase your cholesterol A new study from the University of Warwick has discovered taking too much of the essential mineral selenium in your diet can increase your cholesterol by almost 10%. Childhood obesity: The increasing vascular drama Obesity is one of the most important health problems in industrialized countries irrespective of socio-economic status, age, sex or ethnicity. Health benefits of physical activity more pronounced in women Many experimental studies have found that physical exercise can improve cholesterol levels and subsequently decrease the risks of cardiovascular disease; however, few of these studies have included enough participant diversity to provide ethnic breakdowns. More patients across the world lowering 'bad' cholesterol The percentage of patients lowering their elevated "bad" cholesterol to within target levels nearly doubled in the last decade, according to a multi-national survey reported in Circulation: Journal of the American Heart Association. Patients with lower urinary tract symptoms more likely to suffer from metabolic syndrome Researchers have determined that individuals with mild to severe symptoms of lower urinary tract symptoms (LUTS) are more likely to suffer from metabolic syndrome (MetS), a collection of cardiovascular risk factors thought to be linked by insulin resistance). 'Mirthful Laughter,' Coupled With Standard Diabetic Treatment, Raises Good Cholesterol And May Lower Heart Attack Risk The connection between the body, mind and spirit has been the subject of conventional scientific inquiry for some 20 years. The notion that psychosocial and societal considerations have a role in maintaining health and preventing disease became crystallized as a result of the experiences of a layman, Norman Cousins. In the 1970s, Cousins, then a writer and magazine editor of the popular Saturday Review, was diagnosed with an autoimmune disease. New survey results show huge burden of diabetes In the United States, nearly 13 percent of adults age 20 and older have diabetes, but 40 percent of them have not been diagnosed, according to epidemiologists from the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC), whose study includes newly available data from an Oral Glucose Tolerance Test (OGTT). Athletes not spared from health risks of metabolic syndrome College-age football players who gain weight to add power to their blocks and tackles might also be setting themselves up for diabetes and heart disease later in life, a new study suggests. Nearly half of a sample of collegiate offensive and defensive linemen who underwent a battery of tests for the study had metabolic syndrome. Apple or pear shape is not main culprit to heart woes - it's liver fat For years, pear-shaped people who carry weight in the thighs and backside have been told they are at lower risk for high blood pressure and heart disease than apple-shaped people who carry fat in the abdomen. But new findings from nutrition researchers at Washington University School of Medicine in St. Louis suggest body-shape comparisons don't completely explain risk. More Hdl Cholesterol Current Events and Hdl Cholesterol News Articles |
|||||||||||||||||||||
|
|||||||||||||||||||||
|
|||||||||||||||||||||