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Microwave synthesis connects with the (quantum) dots
June 13, 2008Materials researchers at the National Institute of Standards and Technology (NIST) have developed a simplified, low-cost process for producing high-quality, water-soluble "quantum dots" for biological research. By using a laboratory microwave reactor to promote the synthesis of the widely used nanomaterials, the recently published* NIST process avoids a problematic step in the conventional approach to making quantum dots, resulting in brighter, more stable dots.
Quantum dots are specially engineered nanoscale crystals of semiconductor compounds. The name comes from the fact that their infinitesimal size enables a quantum electronics effect that causes the crystals to fluoresce brilliantly at specific, sharply defined colors. Bright, stable, tiny and tunable across a broad spectrum of colors, quantum dots that are engineered to attach themselves to particular proteins have become a popular research tool in areas such as cancer research for detecting, labeling and tracking specific biomarkers and cells.
Making good quantum dots for biological research is complex. First a semiconductor compound-typically a mixture of cadmium and selenium-must be induced to crystallize into discrete nanocrystals of just the right size. Cadmium is toxic, and the compound also can oxidize easily (ruining the effect), so the nanocrystals must be encapsulated in a protective shell such as zinc sulfide. To make them water soluble for biological applications, a short organic molecule called a "ligand" is attached to the zinc atoms. The organic ligand also serves as a tether to attach additional functional molecules that cause the dot to bind to specific proteins.
The accepted commercial method uses a high-temperature reaction (about 300 degrees Celsius) that must be carefully controlled under an inert gas atmosphere for the crystallization and encapsulation stages. An intermediate ligand material that can tolerate the high temperature is used to promote the crystallization process, but it must be chemically swapped afterwards for a different compound that makes the material water soluble. The ligand exchange step-as well as several variations on the process-is known to significantly alter the luminescence and stability of the resulting quantum dots.
Seeking a better method, NIST researchers turned to microwave-assisted chemistry. Microwaves have been employed in a variety of chemical reactions to reduce the required times and temperatures. Working at temperatures half those of commercial processes, the group developed a relatively simple two-stage process that requires no special atmospheric conditions and directly incorporates the water-soluble ligand into the shell without an exchange step. Using commercially available starting materials, they have synthesized highly uniform and efficient quantum dots for a range of frequencies and shown them to be stable in aqueous solutions for longer than four months.
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* M.D. Roy, A.A. Herzing, S.H. De Paoli Lacerda and M,L. Becker. Emission-tunable microwave synthesis of highly luminescent water soluble CdSe/ZnS quantum dots. Chemical Communications, 2008, 2106-2108.
National Institute of Standards and Technology (NIST)
The accepted commercial method uses a high-temperature reaction (about 300 degrees Celsius) that must be carefully controlled under an inert gas atmosphere for the crystallization and encapsulation stages. An intermediate ligand material that can tolerate the high temperature is used to promote the crystallization process, but it must be chemically swapped afterwards for a different compound that makes the material water soluble. The ligand exchange step-as well as several variations on the process-is known to significantly alter the luminescence and stability of the resulting quantum dots.
Seeking a better method, NIST researchers turned to microwave-assisted chemistry. Microwaves have been employed in a variety of chemical reactions to reduce the required times and temperatures. Working at temperatures half those of commercial processes, the group developed a relatively simple two-stage process that requires no special atmospheric conditions and directly incorporates the water-soluble ligand into the shell without an exchange step. Using commercially available starting materials, they have synthesized highly uniform and efficient quantum dots for a range of frequencies and shown them to be stable in aqueous solutions for longer than four months.
###
* M.D. Roy, A.A. Herzing, S.H. De Paoli Lacerda and M,L. Becker. Emission-tunable microwave synthesis of highly luminescent water soluble CdSe/ZnS quantum dots. Chemical Communications, 2008, 2106-2108.
National Institute of Standards and Technology (NIST)
Quantum Dots Current Events and Quantum Dots News RSSTransforming Nanowires Into Nano-Tools Using Cation Exchange Reactions
A team of engineers from the University of Pennsylvania has transformed simple nanowires into reconfigurable materials and circuits, demonstrating a novel, self-assembling method for chemically creating nanoscale structures that are not possible to grow or obtain otherwise.
U-M physicists create first atomic-scale map of quantum dots
University of Michigan physicists have created the first atomic-scale maps of quantum dots, a major step toward the goal of producing "designer dots" that can be tailored for specific applications.
Graphitic memory techniques advance at Rice
Advances by the Rice University lab of James Tour have brought graphite's potential as a mass data storage medium a step closer to reality and created the potential for reprogrammable gate arrays that could bring about a revolution in integrated circuit logic design.
Atoms don't dance the 'bose nova'
Hanns-Christoph Naegerl's research group has investigated how ultracold quantum gases behave in lower spatial dimensions. They successfully realized an exotic state, where, due to the laws of quantum mechanics, atoms align along a one-dimensional structure.
New DNA Test Uses Nanotechnology to Find Early Signs of Cancer
Using tiny crystals called quantum dots, Johns Hopkins researchers have developed a highly sensitive test to look for DNA attachments that often are early warning signs of cancer.
All-in-one nanoparticle: A Swiss Army knife for nanomedicine
Nanoparticles are being developed to perform a wide range of medical uses -- imaging tumors, carrying drugs, delivering pulses of heat. Rather than settling for just one of these, researchers at the University of Washington have combined two nanoparticles in one tiny package.
NIST develops novel ion trap for sensing force and light
Miniature devices for trapping ions (electrically charged atoms) are common components in atomic clocks and quantum computing research. Now, a novel ion trap geometry demonstrated at the National Institute of Standards and Technology (NIST) could usher in a new generation of applications because the device holds promise as a stylus for sensing very small forces or as an interface for efficient transfer of individual light particles for quantum communications.
Major Breakthrough in Early Detection and Prevention of AMD
A team of researchers led by Dr. Jayakrishna Ambati at the University of Kentucky has discovered a biological marker for neovascular age-related macular degeneration (AMD), the leading cause of blindness in older adults.
Nanoneedle is small in size, but huge in applications
Researchers at the University of Illinois have developed a membrane-penetrating nanoneedle for the targeted delivery of one or more molecules into the cytoplasm or the nucleus of living cells.
Singapore scientists synthesize gold to shed light on cells' inner workings
Highly fluorescent gold nanoclusters for sub-cellular imaging have been synthesized by researchers at the Institute of Bioengineering and Nanotechnology (IBN).
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