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Rheumatoid arthritis is a risk factor for cardiovascular disease
June 16, 2008Rheumatoid arthritis patients have double the risk of cardiovascular events -- comparable to that of diabetes patients
The risk of cardiovascular disease (CVD) for people with rheumatoid arthritis (RA) has been found to be comparable to the risk of CVD in people with type 2 diabetes, according to the conclusions of two studies presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France.
At least one CV-event was reported in 8.6% of the RA population studied, a figure that was double that reported in the general population (4.3%), corresponding with an incidence of 3.14 per 100 patient/years (95% confidence interval (CI): 1.98-4.30) for RA patients, and 1.51 per 100 person/years (95%-CI: 1.18-1.84) for the general population.
In a second study, the age- and gender- adjusted prevalence odds ratios for CVD were found to be 2.3 (95%-CI: 1.3-4.0) for those with type 2 diabetes and 2.0 (95%-CI: 1.1-3.4) for those with RA, indicating a similar CVD risk for the two diseases.
Dr Mike Peters of the VU University Medical Center and Jan van Breemen Institute, Amsterdam, the Netherlands, an investigator in both studies (lead investigator: Dr Michael T Nurmohamed), said, "These two studies suggest that RA should be considered an important cardiovascular disease risk factor. Healthcare professionals treating those with the disease should therefore be aware of this elevated risk and advise their patients to follow a healthy diet and lifestyle and be alert to the early signs and symptoms of CVD in addition to managing their RA."
The studies both examined 353 randomly selected outpatients with RA (from the CARRÉ study) and participants of a population-based cohort study on diabetes and CVD (the Hoorn study). The first study compared 3-year incident CVD in both the CARRÉ and Hoorn studies, using Cox proportional hazards models. In the second, patients with normal fasting glucose levels from the CARRÉ study (n=294) were compared to individuals from the Hoorn study with a normal glucose metabolism (n=258) and individuals with type 2 diabetes (n=194). Both made adjustments for other CV risk factors, i.e. blood pressure, anti-hypertensive agent use, total cholesterol, statin use, waist to hip ratio and smoking.
European League Against Rheumatism
In a second study, the age- and gender- adjusted prevalence odds ratios for CVD were found to be 2.3 (95%-CI: 1.3-4.0) for those with type 2 diabetes and 2.0 (95%-CI: 1.1-3.4) for those with RA, indicating a similar CVD risk for the two diseases.
Dr Mike Peters of the VU University Medical Center and Jan van Breemen Institute, Amsterdam, the Netherlands, an investigator in both studies (lead investigator: Dr Michael T Nurmohamed), said, "These two studies suggest that RA should be considered an important cardiovascular disease risk factor. Healthcare professionals treating those with the disease should therefore be aware of this elevated risk and advise their patients to follow a healthy diet and lifestyle and be alert to the early signs and symptoms of CVD in addition to managing their RA."
The studies both examined 353 randomly selected outpatients with RA (from the CARRÉ study) and participants of a population-based cohort study on diabetes and CVD (the Hoorn study). The first study compared 3-year incident CVD in both the CARRÉ and Hoorn studies, using Cox proportional hazards models. In the second, patients with normal fasting glucose levels from the CARRÉ study (n=294) were compared to individuals from the Hoorn study with a normal glucose metabolism (n=258) and individuals with type 2 diabetes (n=194). Both made adjustments for other CV risk factors, i.e. blood pressure, anti-hypertensive agent use, total cholesterol, statin use, waist to hip ratio and smoking.
European League Against Rheumatism
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Study suggests dentists can identify patients at risk for fatal cardiovascular event
A new study indicates dentists can play a potentially life-saving role in health care by identifying patients at risk of fatal heart attacks and referring them to physicians for further evaluation.
Breeding better broccoli
Carotenoids-fat-soluble plant compounds found in some vegetables-are essential to the human diet and reportedly offer important health benefits to consumers.
Postmenopausal women with higher testosterone levels
Postmenopausal women who have higher testosterone levels may be at greater risk of heart disease, insulin resistance and the metabolic syndrome compared to women with lower testosterone levels.
Researchers identify the three killer indicators that are even worse than high cholesterol
Researchers at the University of Warwick have identified a particular combination of health problems that can double the risk of heart attack and cause a three-fold increase in the risk of mortality.
Help your kidneys: Pass on salt and diet soda
Individuals who consume a diet high in sodium or artificially sweetened drinks are more likely to experience a decline in kidney function, according to two papers being presented at the American Society of Nephrology's annual meeting in San Diego, California.
Research: Migraine and cardiovascular disease: Systematic review and meta-analysis
Migraine with aura (temporary visual or sensory disturbances before or during a migraine headache) is associated with a twofold increased risk of stroke, finds a study published on bmj.com today.
Hunting for the Prozac Gene
Prozac works wonders for some depressed people, but not for others. In some cases, patients derive little benefit and at worst, it can lead to bizarre hallucinations and fits of rage.
Experts unveil new CVD guidelines and position papers
Several new guidelines and position papers offering the most up to date information to ensure that clinicians practice evidence-based medicine were released at the Canadian Cardiovascular Congress 2009 this week.
Barrett's esophagus patients have same survival rates as general population
New Mayo Clinic research has found that survival rates of patients with Barrett's esophagus, which can be a precursor for esophageal cancer, are no different than the survival rates for the general population.
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