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Rheumatoid arthritis factors equal to cardiovascular factors in risk of severe cardiovascular events
June 16, 2008
Certain cardiovascular disease (CVD) risk factors and rheumatoid arthritis (RA) disease factors have a similar effect on an RA patient's risk of experiencing myocardial infarction (MI) or stroke, according to a new study presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France. The researchers studied 10,870 RA patients for a median of 24 months across two cohorts - patients with active RA and those with prior experience of CVD. Cox regression models revealed that the CVD risk factors leading to an increased relative risk of MI or stroke were: non-Caucasian ethnicity (relative risk (RR) 1.26), body mass index (RR 1.25), prior MI (RR 1.75), and any current tobacco use (RR 1.92). The RA disease factors leading to an increased relative risk of MI or stroke were: nodules (RR 1.44), Health Assessment Questionnaire Disability Index (HAQ-DI) (RR 1.20 per each point increase) and the Clinical Disease Activity Index (CDAI) (RR 1.06 per each point increase). The area under the receiver operating characteristic curve (c-statistic) of the CVD risk factor and RA disease factor models (adjusting for age and gender) were both calculated as 0.75, demonstrating a comparable relationship with CVD endpoints for both RA and CVD risk factors..
Lead investigator, Professor Daniel H Solomon of Brigham and Women's Hospital and Harvard Medical School, Boston, USA, said: "It has been established that people with RA are more likely to experience cardiovascular disease or complications than the general population, but our research examines the importance of RA-specific factors compared with traditional cardiovascular risk factors. We have shown that having more high risk RA-specific risk factors increases the CVD risk to a rate similar to that of traditional cardiovascular risk factors. We hope that the results of our study lead to more robust clinical prediction rules for CVD outcomes in RA along with appropriate management and treatment options for the future."
All data were taken from the Consortium of Rheumatology Researchers of North America, Inc. (CORRONA) independent registry, the largest physician-based RA registry in the US, which carries information on over 15,000 patients with RA and other rheumatic conditions. Records for patients who had made at least two visits to healthcare facilities were selected and information about CVD risk factors, with RA disease factors drawn from baseline questionnaires.
CVD outcomes included MI, stroke and transient ischemic attack, reported and then confirmed by the treating rheumatologist. CVD risk factors included a history of coronary artery disease or MI, diabetes, hypertension, family history of premature MI, body mass index, dyslipidemia (assessed as use of a lipid-lowering agent), non-Caucasian ethnicity, and current tobacco use.
RA disease factors included duration of RA, rheumatoid factor status, HAQ, CDAI, subcutaneous nodules, Sjogrens (an autoimmune condition associated with arthritis), tender joint count, swollen joint count, and total joint replacements. These variables were assessed as predictors of CVD outcomes in separate Cox regression models, with age and gender included in both. Finally, the discriminatory value of these variables was assessed by calculating the area under the receiver operating characteristic curve (C statistic) in logistic regression.
European League Against Rheumatism
Science News and Science Current Events Tag Cloud This tag cloud is a visual representation of term frequencies of random science news topics with common terms grouped together and emphasized by their display size.
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Related Cardiovascular Events Current Events and Cardiovascular Events News Articles Cardiovascular Events Current Events and Cardiovascular Events News RSS CPAP treatment linked to lower mortality in stroke patients with OSA Stroke patients with obstructive sleep apnea (OSA) who undergo treatment with continuous positive airway pressure (CPAP) following their stroke may substantially reduce their risk of death.
Inflammation markers linked more with fatal than nonfatal cardiovascular events in elderly A study published this week in the open access journal PLoS Medicine shows that for elderly people at risk of cardiovascular disease, the presence of inflammatory markers in the blood can identify that an individual is at a higher risk of a fatal rather than a non-fatal heart attack or stroke.
More patients across the world lowering 'bad' cholesterol The percentage of patients lowering their elevated "bad" cholesterol to within target levels nearly doubled in the last decade, according to a multi-national survey reported in Circulation: Journal of the American Heart Association.
Benefit of glinides is not proven The benefit of glinides in the treatment of type 2 diabetes is not scientifically proven. Nor do they perform better than other antidiabetics available in tablet form, such as metformin and sulfonylureas.
New American College of Surgeons risk calculator determines colorectal surgery risk New research published in the June issue of the Journal of the American College of Surgeons shows that a risk calculator developed by the American College of Surgeons (ACS) can help surgeons provide patients with more detailed and accurate preoperative information about the risk of death and complications following colorectal surgery.
Health risks begin in overweight range, BMI doesn't tell whole story Being overweight is a health concern, and using only body mass index (BMI) to determine weight classification may not give an accurate picture of a person's health, according to an advisory published in Circulation: Journal of the American Heart Association.
Death rates same for diabetes and heart disease patients receiving drug therapy or surgery There is no difference in mortality among patients with type 2 diabetes and stable heart disease who received prompt bypass surgery or angioplasty compared to drug therapy alone, according to a landmark study focused exclusively on patients with both conditions.
NEJM study finds drug-eluting stents more effective than bare-metal stents in heart attack patients NewYork-Presbyterian Hospital and Columbia University Medical Center, together with the Cardiovascular Research Foundation (CRF), announced that its landmark study comparing the safety and efficacy of drug-eluting stents and bare-metal stents was published in the May 7 New England Journal of Medicine.
Heart disease patients carrying extra pounds do better, live longer Being overweight or obese is a leading contributor to cardiovascular disease (CVD) and associated risk factors; however, in patients with established CVD, obesity appears to play a protective role.
2-week course of sleep aid increases CPAP adherence in OSA patients at 6 months New research suggests that patients newly diagnosed with obstructive sleep apnea (OSA) who use a short-course of the sleep aid, eszopiclone, when beginning continuous positive airway pressure (CPAP) therapy, are more adherent with therapy in six months. More Cardiovascular Events Current Events and Cardiovascular Events News Articles
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Bariatric surgery sharply reduces CV events.(Cardiovascular events)(Disease/Disorder overview): An article from: Internal Medicine News
by Bruce Jancin (Author)
This digital document is an article from Internal Medicine News, published by Thomson Gale on April 15, 2006. The length of the article is 551 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Bariatric surgery sharply reduces CV events.(Cardiovascular events)(Disease/Disorder overview) Author: Bruce Jancin Publication: Internal Medicine News (Magazine/Journal) Date: April 15, 2006 Publisher: Thomson Gale Volume: 39 Issue: 8 Page: 11(1)
Article Type: Disease/Disorder overview
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Spare Parts: Organ Replacement in American Society
by Oxford University Press, USA
The developments that have occurred in the field of organ transplantation during the 1980s and early 1990s, and the simultaneous rise and fall of the Jarvik-7 artificial heart are the subject of this vividly written and absorbing new volume. In Spare Parts, fascinating, interconnected stories of organ transplantation and the artificial heart are recounted in an interpretive framework that explores the vision of the "replaceable body." Themes of uncertainty, gift exchange, and the allocation of scarce material and non-material resources underscore a discussion that openly examines the escalating ardor about the goodness of repairing and remaking people with transplanted organs. Likewise, the stories open questions of life and death, identity, and solidarity. This important book offers...
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Diet Rich in Omega-3 Fatty Acids Reduces Cardiovascular Events.: An article from: Family Practice News
by Karen A. Batoosingh (Author)
This digital document is an article from Family Practice News, published by International Medical News Group on August 1, 1999. The length of the article is 594 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Diet Rich in Omega-3 Fatty Acids Reduces Cardiovascular Events. Author: Karen A. Batoosingh Publication: Family Practice News (Magazine/Journal) Date: August 1, 1999 Publisher: International Medical News Group Volume: 29 Issue: 15 Page: 16
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Four biomarkers predict cardiovascular events in women.(Cardiovascular Medicine): An article from: Internal Medicine News
by Bruce Jancin (Author)
This digital document is an article from Internal Medicine News, published by International Medical News Group on May 1, 2005. The length of the article is 636 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Four biomarkers predict cardiovascular events in women.(Cardiovascular Medicine) Author: Bruce Jancin Publication: Internal Medicine News (Magazine/Journal) Date: May 1, 2005 Publisher: International Medical News Group Volume: 38 Issue: 9 Page: 56(1)
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Aspirin prophylaxis cuts strokes in healthy women: women aged 65 or older had reductions in ischemic stroke, MI, and all major cardiovascular events.(Across ... An article from: Clinical Psychiatry News
by Mitchel L. Zoler (Author)
This digital document is an article from Clinical Psychiatry News, published by International Medical News Group on May 1, 2005. The length of the article is 1447 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Aspirin prophylaxis cuts strokes in healthy women: women aged 65 or older had reductions in ischemic stroke, MI, and all major cardiovascular events.(Across Specialties) Author: Mitchel L. Zoler Publication: Clinical Psychiatry News (Magazine/Journal) Date: May 1, 2005 Publisher: International Medical News Group Volume: 33 Issue: 5 Page:...
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Chronic kidney disease: statins not renoprotective: cardiovascular event rate may be reduced.(News): An article from: Internal Medicine News
by Nancy Walsh (Author)
This digital document is an article from Internal Medicine News, published by International Medical News Group on December 1, 2008. The length of the article is 844 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.
Citation Details Title: Chronic kidney disease: statins not renoprotective: cardiovascular event rate may be reduced.(News) Author: Nancy Walsh Publication: Internal Medicine News (Magazine/Journal) Date: December 1, 2008 Publisher: International Medical News Group Volume: 41 Issue: 23 Page: 1(2)
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Screening echo predicts first cardiovascular events in elderly: supplements conventional assessment.(Clinical Rounds): An article from: Family Practice News
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This digital document is an article from Family Practice News, published by International Medical News Group on September 1, 2003. The length of the article is 427 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Screening echo predicts first cardiovascular events in elderly: supplements conventional assessment.(Clinical Rounds) Publication: Family Practice News (Magazine/Journal) Date: September 1, 2003 Publisher: International Medical News Group Volume: 33 Issue: 17 Page: 18(1)
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Pro & Con: Is routine ACE inhibitor therapy warranted in patients at high risk for cardiovascular events?: An article from: Internal Medicine News
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This digital document is an article from Internal Medicine News, published by International Medical News Group on June 1, 2002. The length of the article is 1002 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Pro & Con: Is routine ACE inhibitor therapy warranted in patients at high risk for cardiovascular events? Publication: Internal Medicine News (Magazine/Journal) Date: June 1, 2002 Publisher: International Medical News Group Volume: 35 Issue: 11 Page: 12(1)
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Waist girth, exercise tolerance predict cardiovascular event risk.(Cardiovascular Medicine): An article from: Family Practice News
by Mitchel L. Zoler (Author)
This digital document is an article from Family Practice News, published by Thomson Gale on February 15, 2006. The length of the article is 486 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Waist girth, exercise tolerance predict cardiovascular event risk.(Cardiovascular Medicine) Author: Mitchel L. Zoler Publication: Family Practice News (Magazine/Journal) Date: February 15, 2006 Publisher: Thomson Gale Volume: 36 Issue: 4 Page: 19(1)
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Keep aspirin below 100 mg/day for vascular events.(Cardiovascular Medicine): An article from: Internal Medicine News
by Bruce Jancin (Author)
This digital document is an article from Internal Medicine News, published by International Medical News Group on May 15, 2005. The length of the article is 774 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Keep aspirin below 100 mg/day for vascular events.(Cardiovascular Medicine) Author: Bruce Jancin Publication: Internal Medicine News (Magazine/Journal) Date: May 15, 2005 Publisher: International Medical News Group Volume: 38 Issue: 10 Page: 58(1)
Distributed by Thomson...
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