 |
|
Estrogen therapy helps or hurts the brain depending on reproductive status
June 16, 2008Estrogen therapy may limit stroke damage if started close to, but not long after reproductive cycles are over, according to a new animal study. The results were presented Sunday, June 15, at The Endocrine Society's 90th Annual Meeting in San Francisco.
"This study suggests that estrogen treatment is not toxic per se but that its effects on the brain depend on the individual's reproductive age when therapy begins," said one of the study's authors, Farida Sohrabji, PhD, of Texas A & M Health Science Center.
In their study in rats, Amutha Selvamani, a post-doctoral associate and Dr. Sohrabji, found "that estrogen treatment is not beneficial to the brain once the animal is in an acylic state, but is effective when given earlier. This acyclic stage in animals shares similarities with the menopausal stage in women."
Since the Women's Health Initiative study found that long-term therapy with estrogen or estrogen plus progestin may increase the risk of heart attack and stroke, many women have found it difficult to decide whether to take hormone therapy at menopause. Subsequently, several researchers have speculated that the timing of estrogen treatment may be important for estrogen's effects. The authors therefore designed an animal study to determine if estrogen would be beneficial for females who are going through menopause (perimenopausal) but not for women who are postmenopausal for many years. Since it is not possible to measure "risk" in animal studies, the authors measured severity of stroke injury.
Therefore, they compared groups of female rats: mature adults and older, "acyclic" rats that no longer had reproductive cycles. The physiologic status of the older rats resembled that of a postmenopausal woman, and the other rats' status would be more similar to perimenopause, according to Sohrabji. After surgically removing the ovaries of all the rats, the researchers gave them estrogen replacement therapy (estradiol) for 3 weeks. Then they induced a stroke in all the animals. A week later, the rats' brains were studied for tissue damage.
The stroke caused much more tissue damage in the acyclic older females, the authors reported. "Estrogen treatment to this group actually increased the volume of the brain that was damaged," Sohrabji said.
In the mature adult rats, however, estrogen therapy apparently reduced the area of brain damage. After the stroke all rats showed evidence of sensory and motor damage on behavioral testing, but it was more severe in the acyclic rats.
"This study supports the idea that there is a narrow window of time as a woman approaches menopause and immediately afterward where estrogen therapy may provide neuroprotective benefits," Sohrabji said.
The Endocrine Society
Since the Women's Health Initiative study found that long-term therapy with estrogen or estrogen plus progestin may increase the risk of heart attack and stroke, many women have found it difficult to decide whether to take hormone therapy at menopause. Subsequently, several researchers have speculated that the timing of estrogen treatment may be important for estrogen's effects. The authors therefore designed an animal study to determine if estrogen would be beneficial for females who are going through menopause (perimenopausal) but not for women who are postmenopausal for many years. Since it is not possible to measure "risk" in animal studies, the authors measured severity of stroke injury.
Therefore, they compared groups of female rats: mature adults and older, "acyclic" rats that no longer had reproductive cycles. The physiologic status of the older rats resembled that of a postmenopausal woman, and the other rats' status would be more similar to perimenopause, according to Sohrabji. After surgically removing the ovaries of all the rats, the researchers gave them estrogen replacement therapy (estradiol) for 3 weeks. Then they induced a stroke in all the animals. A week later, the rats' brains were studied for tissue damage.
The stroke caused much more tissue damage in the acyclic older females, the authors reported. "Estrogen treatment to this group actually increased the volume of the brain that was damaged," Sohrabji said.
In the mature adult rats, however, estrogen therapy apparently reduced the area of brain damage. After the stroke all rats showed evidence of sensory and motor damage on behavioral testing, but it was more severe in the acyclic rats.
"This study supports the idea that there is a narrow window of time as a woman approaches menopause and immediately afterward where estrogen therapy may provide neuroprotective benefits," Sohrabji said.
The Endocrine Society
Estrogen Therapy Current Events and Estrogen Therapy News RSSLow-dose estrogen shown safe and effective for metastatic breast cancer
When estrogen-lowering drugs no longer control metastatic breast cancer, the opposite strategy might work. Raising estrogen levels benefited 30 percent of women whose metastatic breast cancer no longer responded to standard anti-estrogen treatment.
Mayo Clinic researchers say agent provides treatment option for women with hot flashes
A pill used for nerve pain offers women relief from hot flashes, Mayo Clinic researchers report at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO).
New study suggests Rx estrogen delivery through the skin may show safety benefits as opposed to oral delivery
Transdermal delivery of estrogen therapy available by prescription "seems not to alter" the risk of venous thromboembolism (VTE), or blood clotting, in postmenopausal patients when compared to oral delivery, a new study suggests.
Hormone therapy associated with reduced colorectal cancer risk
The combination of estrogen plus progestin, which women stopped taking in droves following the news that it may increase their risk of breast cancer, may decrease their risk of colorectal cancer, according to a report published in the January issue of Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research.
Estrogen therapy could be dangerous for women with existing heart risk
Hormone therapy could accentuate certain pre-existing heart disease risk factors and a heart health evaluation should become the norm when considering estrogen replacement, new research suggests.
New predictive tool can help determine treatment of breast cancer patients
A new predictive measurement, called a PEPI score, could bring good news to many women diagnosed with early stage breast cancer - a low PEPI (preoperative endocrine prognostic index) score could show that they have little risk of relapse and can safely avoid chemotherapy after surgery.
Risk of death after cancer diagnosis; shift in stage of breast cancer diagnosis
Cancer patients with low socioeconomic status (SES) have more advanced cancers at diagnosis, receive less aggressive treatment, and have a higher risk of dying in the five years following cancer diagnosis, according to a new study.
Popular osteoporosis drugs triple risk of bone necrosis
A University of British Columbia and Vancouver Coastal Health Research Institute study has found that a popular class of osteoporosis drugs nearly triples the risk of developing bone necrosis, a condition that can lead to disfigurement and incapacitating pain.
Effects of progesterone on Alzheimer's disease
The first study on progesterone and Alzheimer's disease has found no clear preventive benefit for the widely prescribed hormone in an animal model.
Study Suggests Estrogen Deficiency Can Lead To Obesity-Induced
At menopause, women lose hormone protection against heart (cardiovascular) and kidney (renal) diseases, and are likely to become obese.
More Estrogen Therapy Current Events and Estrogen Therapy News Articles
 |
The Estrogen Alternative: Natural Hormone Therapy with Botanical Progesterone by Raquel Martin (Author), D.C., Judi Gerstung (Contributor) Includes the latest research on how to combat osteoporosis, endometriosis, heart disease, PMS, fibroids, and breast, ovarian, and uterine cancer. * A must-read for any woman taking synthetic hormones for infertility or birth control, PMS, or menopause. * Explains the most recent research on diet, endometriosis, osteoporosis, and breast, ovarian, and uterine cancer. * Previous editions have sold more than 50,000 copies. In this revised and expanded third edition, Raquel Martin offers the most up-to-date information on how botanical progesterone therapy can offer safe, natural relief for many of the discomforts women face from hormone deficiency, including PMS, menstrual irregularity, infertility, depression, uterine fibroids, and the symptoms of ... |
 |
Remifemin Menopause Herbal Supplement, Estrogen Free, 120 Tablets by Remifemin Remifemin, the #1 OB/GYN recommended OTC menopausal therapy. Clinically shown to reduce menopausal symptoms including hot flashes, night sweats, mood swings, irritability, related occasional sleeplessness. Effectively used by over 1.5 million women. |
 |
Redefine Nutrition Revolution by Redefine Nutrition PCT Revolution is the most pivotal advancement in Post Cycle Therapy ever introduced. Combining five essential pieces to the PCT puzzle, Redefine Nutrition has raised the bar in Legal Post Cycle Therapy with the introduction of PCT Revolution. Taken as directed, PCT Revolution will revitalize testosterone levels leading to increased energy, strength, and sex drive. |
 |
Go Red: Women's Heart Health Stanford University Medical Center celebrates National Heart Month with an informative Go Red event. Heart disease is the number one killer of women, taking the lives of over half a million women every year. The Go Red for Women campaign's mission is to educate and create awareness regarding women and heart disease, enabling women to live stronger, longer lives. This program provides information on nutrition, cardiac imaging, and prevention of cardiovascular diseases. This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply. |
|
Low-dose estrogen boosts BMD in older women: small study.(Women's Health): An article from: Family Practice News by Heidi Splete (Author) This digital document is an article from Family Practice News, published by International Medical News Group on October 1, 2003. The length of the article is 540 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Low-dose estrogen boosts BMD in older women: small study.(Women's Health) Author: Heidi Splete Publication: Family Practice News (Magazine/Journal) Date: October 1, 2003 Publisher: International Medical News Group Volume: 33 Issue: 19 Page: 54(1) Distributed by Thomson... | |
 |
Emerita Pro-Gest Body Cream 2 oz by Emerita Pro-Gest Cream is a natural progesterone cream to help women maintain balance and harmony in life and with their bodies by offering support for the physical and emotional symptoms associated with menopause. Pro-Gest? cream is manufactured to contain 450 milligrams (mg) of USP Progesterone per ounce (900 mg per two-ounce tube). Each ? tsp contains approximately 20 mg of USP Progesterone. Careful clinical research has shown this to be an effective amount to achieve a natural balance. United States Pharmacopoeia (USP) Progesterone is progesterone that exactly duplicates the progesterone naturally produced in the body. It's sometimes referred to as "human-identical" or "bio-identical" progesterone. The title "USP Progesterone" differentiates natural progesterone from synthetic progestins or... |
 |
Caring for the Surgically Menopausal Patient: A Physiological Renaissance Also With: NCI (Producer), Dr. Gloria Bachmann (Host) Caring for the Surgically Menopausal Patient is a highlights Videostat produced by Nelson Communciations, Inc. A symposium, chaired by Dr. Gloria Bachmann, covered the Pre, Peri and Post operative management issues of the surgically menopausal patient. This video cover the key highlights of the meeting. 1) Pre-Operative and Patient Evaluation 2) Hysterectomies - Maximize Patient Comfort and Minimize Cost 3) Managing Post-Operative Patients. |
 |
Natural Alternatives to HRT (Hormone Replacement Therapy) Cookbook : Understanding Estrogen and Food that Benefits Your Health by Marilyn Glenville (Author) Joint pains, mood swings, weight gain, and hot flashes-all familiar symptoms to every woman experiencing menopause. As unavoidable as menopause is, Marilyn Glenville demonstrates that its symptoms can be avoided, or at least alleviated. How? Thankfully, the solution is not the controversial and risky hormone replacement therapy, but a safe and natural alternative-your diet. Certain foods have been scientifically proven to benefit your health, particularly during menopause. In the Natural Alternatives to HRT Cookbook, Glenville outlines the beneficial effects of a variety of foods and provides savory and sweet recipes that will help you remain healthy and vigorous during menopause. Lavishly illustrated with beautiful photography, each delicious recipe has been specifically designed to... |
 |
Progesterone (Bio-Identical) Creme Plus Herbs - Fragrance Free/Unscented 8 oz. Pump Bottle by Radiant Laboratories - Made In USA Paraben-Free and Unscented. Replenish Your Progesterone Naturally and Safely. Don't suffer needessly with hot flashes and night sweats. Get your life back and feel good again. USP Progesterone from Wild Yam is Bio-identical to what is produced in the human body. The "Plus" is our Herbal Complex for Adrenal Gland Support. Feel Good Again! Hormone Replacement with Bio-Identical Hormones are Safe and Effective. WHY A CRÈME? Natural progesterone taken orally is mostly destroyed in the digestion process. Adequate absorption is only accomplished through topical application in a dermal delivery system. HAVE YOU EXPERIENCED ANY OF THESE SYMPTOMS? Migraines, Fatigue, Irritability, Cramping, Anxiety, Mood Swings, Depression, Fat Gain, Water Retention, Foggy Thinking, Breast Tenderness, Fibrocystic... |
 |
Enzymatic Therapy Protective Breast Formula (60 Tablets) by Enzymatic Dietary supplement with natural ingredients to promote breast health. |
| © 2009 BrightSurf.com |