Study Underway to Find an Alternative Cure for Crohn's Disease and Ulcerative ColitisJune 17, 2008CHICAGO - Two research studies evaluating dietary changes and complementary medicine for the treatment of inflammatory bowel diseases (IBD) have been launched at Rush University Medical Center. Funded by the National Institute of Health, one study will look at the impact of mind/body medicine on patients suffering from ulcerative colitis (UC) and the other will assess how diet impacts patients with Crohn's Disease. There are two main types of IBD, Crohn's disease and UC, which afflict approximately one million Americans. These diseases cause chronic inflammation of the intestinal tract, causing a variety of symptoms such as abdominal pain, diarrhea and rectal bleeding. "Both Crohn's disease and ulcerative colitis are due to an autoimmune response to the bacteria or bacterial antigens inside the intestines," said Dr. Ali Keshavarzian, director of digestive diseases and nutrition at Rush and principal investigator and co-investigator on the studies. "Basically, the immune system is having an abnormally aggressive reaction to the bacteria." "We want to control flare-ups of the diseases," said Keshavarzian. "Unfortunately, the treatments for IBD can be toxic and risky. There are increased risks of cancer, infection and even death as a result of IBD treatment. That's why we're looking at how diet as well as stress relate to the flare-ups. It may be that if we can lower stress and get the right diet, we may be able to control these illnesses." Mind/Body Alternatives for Treating Ulcerative Colitis One study is looking for participants suffering from UC in order to find out if complementary and alternative medicine techniques may help reduce the effects when conventional medicine has not been successful. "We're looking at the relationship between stress and ulcerative colitis flare-ups," said Dr. Sharon Jedel, clinical psychologist in the section of gastroenterology at Rush and the study's co-investigator. "The trial includes education about stress and training individuals in certain stress reduction techniques using alternative therapies." "Approximately 40 percent of patients with IBD use complementary and alternative medicine; however, there is a lack of scientific evidence of the efficacy," said Keshavarzian. "Complementary treatments and services are a large, yet hidden section of our health care system." Rush is looking to enroll 100 subjects suffering from moderately severe UC who have experienced a flare-up in the last six months. Participants will be assigned randomly to one of two possible eight-week courses on mind/body medicine. Research on Diet's Effect on Crohn's Disease The second study which is a dietary trial is looking for 90 participants with Crohn's disease to see if diet adjustments as well as dietary food supplements promoting the growth of good bacteria might help control flare ups. "We're trying to get improve the mix of bacteria in the intestines of patients with IBD. Imagine making a picture with different colors," said Dr. Ece A. Mutlu, gastroenterologist at Rush and principal investigator on the study. "It could be terrible or harmonious depending on the composition and quantity of certain colors. We're trying to create a harmonious environment in the intestines with the right types of bacteria." "One of the many advantages of coming to Rush is that we're looking for alternatives to IBD treatment that may have less side effects," says Mutlu. "Our hope is to find a number of solutions to control these debilitating diseases." To enroll in the dietary study for Crohn's Disease, contact Susan L. Mikolaitis at 312-563-3892. For more information about the ulcerative colitis and stress study, contact Mary Marshall at 312-942-2845. About Ulcerative Colitis Ulcerative Colitis (UC) is a type of inflammatory bowel disease which affects only the innermost lining of the large intestine or colon and the rectum. It occurs in individuals of all ages, but is more common in people between the ages of 15 and 30. Additionally, Caucasians, people of Jewish heritage and those with a family history have an increased risk. About Crohn's Disease Crohn's Disease, sometimes called ileitis or enteritis, is a type of inflammatory bowel disease which can affect any area of the digestive tract, from the mouth to the anus. However, it is most common in the lower part of the small intestine called the ileum. Crohn's Disease occurs in individuals of all ages, but it is more common in people between the ages of 20 and 30. Additionally, people of Jewish heritage and those with a family history have an increased risk. Rush University Medical Center |
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| Related Ulcerative Colitis Current Events and Ulcerative Colitis News Articles M. D. Anderson redefines screening guidelines for breast, cervical and colorectal cancers Drawing on years of experience in cancer research and patient care, The University of Texas M. D. Anderson Cancer Center released today the most comprehensive, risk-based screening guidelines publicly available to date for breast, cervical and colorectal cancers. Probiotic Found to Be Effective Treatment for Colitis In Mice The probiotic, Bacillus polyfermenticus, can help mice recover from colitis, a new study has found. Discovery of genetic defect may lead to better treatments for common gut diseases New findings related to an uncommon genetic disorder may impact the diagnosis and treatment of inflammatory bowel disease (IBD), the most common chronic gastrointestinal illness in children and teens. Two million Americans have IBD which involves inflammation of the gastrointestinal tract. Oxidized form of a common vitamin may bring relief for ulcerative colitis New research published in the Journal of Leukocyte Biology finds retinoic acid may alleviate ulcerative colitis and similar irritable bowel diseases. Promising new target emerges for autoimmune diseases University of Michigan scientists say they have uncovered a fundamentally new mechanism that holds in check aggressive immune cells that can attack the body's own cells. Subclinical markers predict relapse in juvenile idiopathic arthritis post methotrexate withdrawal Elevated levels of the inflammatory biomarkers Myeloid Related Protein (MRP) 8/14 predict an increased risk of relapse following withdrawal of methotrexate (MTX) therapy in children with juvenile idiopathic arthritis (JIA) who have achieved inactive disease status. Electronic Pill Shows Its Smarts by Measuring pH Levels in Digestive Tract An electronic diagnostic tool called the SmartPill is swallowed by patients in order to take measurements as it travels through the gastrointestinal tract. Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD). UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage UCLA scientists have linked for the first time intestinal inflammation with systemic chromosome damage in mice, a finding that may lead to the early identification and treatment of human inflammatory disorders. Chronic diarrhea unresponsive to conventional medication: Are you taking lansoprazole? Lansoprazole is a proton pump inhibitor which powerfully suppresses gastric acid production and is widely prescribed for chronic use in gastroesophageal reflux disease. More Ulcerative Colitis Current Events and Ulcerative Colitis News Articles |
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