Science Current Events | Science News | Brightsurf.com
 
Email a Friend Send to a friend
Printer Friendly Print Shilatifard Lab Identifies New Role for Factor Critical to Transcription

Shilatifard Lab Identifies New Role for Factor Critical to Transcription

June 18, 2008

The Stowers Institute's Shilatifard Lab has identified a new role for the elongation factor ELL in gene transcription by RNA polymerase II (Pol II) - the enzyme that synthesizes messenger RNA to carry genetic information from DNA to the protein-synthesizing machinery of the cell.

Precise control of the timing and location of transcript elongation by Pol II is essential for development. In a paper published online in the Early Edition of the Proceedings of the National Academy of Science (PNAS), the team found that ELL plays a fundamental role in the regulation of gene expression by causing temporary interruptions of the action of Pol II in the fruit fly (Drosophila melanogaster).




"Biological mechanisms such as the 'pausing' of Pol II at nearby promoters have been found at many regulated genes," explained Ali Shilatifard, Ph.D., Investigator. "In this study, we wanted to determine whether the elongation factor ELL is required for the regulation of the temporary interruptions of Pol II transcription in a living organism."

"ELL is found in translocation with the MLL gene in childhood leukemia," said Edwin Smith, Ph.D., Research Scientist in the Shilatifard Lab. "We know very little about the role of these factors in the pathogenesis of leukemia and, therefore, understanding the molecular basis of ELL function will be instrumental for future studies aimed at developing targeted therapeutics for the treatment of translocation-based leukemia."

The Shilatifard Lab will continue to work with the reagents developed in this study to learn more about the molecular properties of ELL in the fruit fly in the hope of elucidating the role of ELL in human disease.

Additional contributors to the publication include Benjamin Winter, Stowers Institute Research Technician I, and Joel Eissenberg, Ph.D., Professor of Biochemistry and Molecular Biology at St. Louis University.

Learn more about Dr. Shilatifard's work at www.stowers-institute.org/labs/ShilatifardLab.asp.

About the Stowers Institute
Housed in a 600,000 square-foot state-of-the-art facility on a 10-acre campus in the heart of Kansas City, Missouri, the Stowers Institute for Medical Research conducts basic research on fundamental processes of cellular life. Through its commitment to collaborative research and the use of cutting-edge technology, the Institute seeks more effective means of preventing and curing disease. The Institute was founded by Jim and Virginia Stowers, two cancer survivors who have created combined endowments of $2 billion in support of basic research of the highest quality.

Stowers Institute



Related Transcription Current Events and Transcription News Articles Transcription Current Events and Transcription News RSS Transcription Current Events and Transcription News RSS
Technique finds gene regulatory sites without knowledge of regulators
A new statistical technique developed by researchers at the University of Illinois allows scientists to scan a genome for specific gene-regulatory regions without requiring prior knowledge of the relevant transcription factors.

New research into the mechanisms of gene regulation
A team led by Penn State's Ross Hardison, T. Ming Chu Professor of Biochemistry and Molecular Biology, has taken a large step toward unraveling how regulatory proteins control the production of gene products during development and growth.

GEN reports on enhancing the applications of qPCR
Quantitative polymerase chain reaction (qPCR) technology is experiencing a surge of interest and rapid expansion as a result of advances such as instrumentation that pushes capacity to 1,536 wells and optimization-free multiplexing.

Scientists find molecular trigger that helps prevent aging and disease
Researchers at Mount Sinai School of Medicine set out to address a question that has been challenging scientists for years: How do dietary restriction-and the reverse, overconsumption-produce protective effects against aging and disease?

'Cross-talk' mechanism contributes to colorectal cancer
Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors.

No-entry zones for AIDS virus
The AIDS virus inserts its genetic material into the genome of the infected cell. Scientists of the German Cancer Research Center have now shown for the first time that the virus almost entirely spares particular sites in the human genetic material in this process. This finding may be useful for developing new, specific AIDS drugs.

New paper describes connections between Circadian and metabolic systems
A paper by University of Notre Dame biologist Giles Duffield and a team of researchers offers new insights into a gene that plays a key role in modulating the body's Circadian system and may also simultaneously modulate its metabolic system.

Novel mouse gene reduces major pathologies associated with Alzheimer's disease
A new study reveals that a previously undiscovered mouse gene reduces the two major pathological perturbations commonly associated with Alzheimer's disease (AD).

Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.

Researchers 'notch' a victory toward new kind of cancer drug
Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed.
More Transcription Current Events and Transcription News Articles
Sony FS85USB Digital Recorder Transcription Kit

Sony FS85USB Digital Recorder Transcription Kit
by Sony

Transcribe your digital voice recordings onto your PC using the Sony FS-85USB Digital Voice Recorder Transcription Kit. This kit, which works with Sony Memory Stick as well as the included CD-ROM with Digital Voice Editor Software, offers you features like the Three Function (Play/Rewind/FF) USB Connected Foot Control, and Adjustable Automatic Secretarial Backspace. An A-B Repeat Function, a Voice Email Function, and Digital Pitch Control are additional features. Transcribing recordings was never this easy - the FS-85USB.PRODUCT FEATURES: Transcribe digital voice recordings on the PC; Professional style transcription listening device; Three function (Play/Rewind/FF) USB connected foot control; Works with Sony Memory Stick and Digital Voice Editor software; Adjustable Automatic Secretarial...

Transcription Kit, AS-2400PC Kit,

Transcription Kit, AS-2400PC Kit,
by Olympus

AS-2400 Transcription Kit allows easy transfer from the voice recorder to the secretary's office. Besides the DSS player standard transcription module, the kit also includes the RS-28 footswitch and the E-102 stereo headset to make hands-free operation of the DS-2400 possible.

You're a Medical What!?!: A Lighthearted Peek into the World of a Medical Transcriptionist

You're a Medical What!?!: A Lighthearted Peek into the World of a Medical Transcriptionist
by Sara Burns (Author)

There is an abundance of resource books for current as well as aspiring medical transcriptionists, and there is a small handful of humourous books, but there is nothing on the market that combines lighthearted anecdotal content with sound how-to advice. At last, a book that appeals to anyone who is curious about the world of medicine, and more specifically how medical transcription fits into that picture. It provides a peek into a part of that world, and informs and teaches as it entertains.

Sony M2020A Dictation / Transcription System

Sony M2020A Dictation / Transcription System
by Sony

M-2020 is truly an "all purpose" machine that works as a desktop dictating machine, desktop transcribing machine, records conferences and interviews and can even record telephone conversations using readily available microcassettes at your choice of two different recording speeds. Its slide switch hand microphone makes dictation easy and the two function foot control, adjustable speed control and automatic backspace provide all the necessary features for transcription accuracy. Compact, fully featured with hand microphone, foot control and listening device included, the M-2020 is ready to work right out of the box.

Liszt/Beethoven: Symphony No. 9 (Transcription for Two Pianos)

Liszt/Beethoven: Symphony No. 9 (Transcription for Two Pianos)
by Liszt
Beethoven (Composer), Wass (Composer), McCawley (Composer)



PC Transcription Kit for Digital Voice Recorder (SYOICRB220)

PC Transcription Kit for Digital Voice Recorder (SYOICRB220)
by SANYO USA-BSD

PC Transcription Kit for Digital Voice Recorder (SYOICRB220)

Machine Transcription & Dictation (with CD-ROM)

Machine Transcription & Dictation (with CD-ROM)
by Mitsy Ballentine (Author)

The fifth edition of this popular transcription book is designed to prepare students for most situations requiring transcription skills. The addition of speech and voice recognition technology gives this book the leading advantage over the competition. As a skill needed by office professionals, especially in the legal and medical fields, speech and voice technology gets a great deal of coverage in this edition.

  Fcc Daily Digest
by Intl Transcriptions Services

The Daily Digest provides a brief synopsis of Commission orders, news releases, speeches, public notices & all other FCC documents that are released each business day. It is released on paper, via email and on the FCC Web Site by about 1:30 p.m. and contains hypertext links to the listed documents.

Olympus AS-2300 PC Transcription Kit

Olympus AS-2300 PC Transcription Kit
by Olympus

The AS-2300 kit is ideal for transcription of digitally recorded documents. The AS-2300 includes: DSS Player software CD-ROM with support for the RS-25 footpedal. For Windows 98/98SE/ME/2000 Professional/XP Professional or Home Edition/NT Workstation 4.0 SP4 or newer and Apple Macintosh OS 9.0 or newer systems with USB port; RS-25 Footpedal; and E-102 stereo headset.DSS Player software is used to download DSS files from your Olympus DS or DM series digital recorder. The RS-25 Footpedal will control playback of the file. The stereo headset connects to your computer's soundcard to privately listen to the playback of the files rather than through speakers that could disturb others.For a complete compatibility list please refer to the original manufacturer's web site.

Bach: Transcriptions

Bach: Transcriptions
Edward Elgar (Composer), Gustav Mahler (Composer), Arnold Schoenberg (Composer), Leopold Stokowski (Composer), Anton Webern (Composer), Esa-Pekka Salonen (Composer), Los Angeles Philharmonic New Music Group (Composer)



© 2009 BrightSurf.com