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Unlocking genome of world's worst insect pest
June 18, 2008
Scientists from CSIRO and the University of Melbourne in Australia, and the Baylor College of Medicine in Houston, Texas, are on the brink of a discovery which will facilitate the development of new, safe, more sustainable ways of controlling the world's worst agricultural insect pest - the moth, Helicoverpa armigera. The Australian Minister for Innovation, Industry, Science and Research, Senator the Hon Kim Carr, said - at the BIO 2008 International Convention in San Diego, California - that the team was expected to sequence the moth's genome in about four months.
"This will allow the collaborating scientists and a worldwide consortium of specialists to work on new ways of controlling this pest," Senator Carr said.
According to CSIRO's Group Executive for Agribusiness, Dr Joanne Daly, these include: the molecular basis of resistance to chemical and Bt insecticides and population genetics related to the refuge strategies in place to help prevent Helicoverpa from developing resistance to Bt transgenic cottons.
"This moth is resistant to nearly every class of chemical pesticide and threatens the long-term viability of transgenic crops which are reliant on the biological pesticide, Bt," Dr Daly said.
"The sequencing of the genome will greatly facilitate this research by improving the power, cost effectiveness and insights from the genetic work on this species and its American cousin H. zea," University of Melbourne Associate Professor Philip Batterham said.
Senator Carr said that finding the moth's Achilles heel was critically important to agriculture worldwide.
"The moth causes $225 million of damage a year in Australia - $5 billion globally - to crops such as cotton, legumes and vegetables," he said.
"Our scientists are already world leaders in research on the genetics and ecology of Helicoverpa and its close relatives.
"This project - led by CSIRO Entomology's Dr John Oakeshott and Associate Professor Batterham - will build on Australia's role. Working together with our partners at Germany's Max Planck Institute for Chemical Ecology and France's National Institute for Agricultural Research, the project will help establish us as leaders in organising major insect genome projects."
The project is another example of what can be achieved through collaboration between scientists and their institutions both in Australia and overseas, he said.
CSIRO
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Related Genome Current Events and Genome News Articles Genome Current Events and Genome News RSS Time of day matters to thirsty trees, U of T researcher discovers The time of day matters to forest trees dealing with drought, according to a new paper produced by a research team led by Professor Malcolm Campbell, University of Toronto Scarborough's vice-principal for research and colleagues in the department of cell and systems biology at the St. George campus.
Genetic analysis helps dissect molecular basis of cardiovascular disease Using highly precise measurements of plasma lipoprotein concentrations determined by nuclear magnetic resonance spectroscopy (NMR), researchers led by Daniel Chasman at Brigham and Women's Hospital and Harvard Medical School in Boston, MA, the Framingham Heart Study in Framingham, and the PROCARDIS consortium in Stockholm, Sweden and Oxford, England performed genetic association analysis across the whole genome among 17,296 women of European ancestry from the Women's Genome Health Study.
Gene mismatch influences success of bone marrow transplants A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of Nature Genetics.
Scientists at UA, collaborating institutions decode maize genome Scientists from the University of Arizona led by Arizona Genomics Institute director Rod A. Wing and from collaborating institutions have deciphered the complete genetic code of the maize plant for the first time.
Ancestry attracts, but love is blind People preferentially marry those with similar ancestry, but their decisions are not necessarily based on hair, eye or skin colour.
WPI Researchers Take Aim at Hard-to-Treat Fungal Infections A team of researchers at the Worcester Polytechnic Institute (WPI) Life Sciences and Bioengineering Center at Gateway Park has developed a new model system to study fungal infections.
Technique finds gene regulatory sites without knowledge of regulators A new statistical technique developed by researchers at the University of Illinois allows scientists to scan a genome for specific gene-regulatory regions without requiring prior knowledge of the relevant transcription factors.
Causative gene of a rare disorder discovered by sequencing only protein-coding regions of genome For the first time, scientists have successfully used a method called exome sequencing to quickly discover a previously unknown gene responsible for a mendelian disorder.
New research into the mechanisms of gene regulation A team led by Penn State's Ross Hardison, T. Ming Chu Professor of Biochemistry and Molecular Biology, has taken a large step toward unraveling how regulatory proteins control the production of gene products during development and growth.
Maize cell wall genes identified, giving boost to biofuel research Purdue University scientists have helped identify and group the genes thought to be responsible for cell wall development in maize, an effort that expands their ability to discover ways to produce the biomass best suited for biofuels production. More Genome Current Events and Genome News Articles
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Genome: The Autobiography of a Species in 23 Chapters (P.S.)
by Matt Ridley (Author)
The genome's been mapped. But what does it mean? Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications...
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Genome
by Matt Ridley (Author)
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Genomes 3
by Terry Brown (Author)
Covering molecular genetics from the basics through to genome expression and molecular phylogenetics, Genomes 3 is the latest edition of this pioneering textbook. Newly updated to incorporate the recent major advances, Genomes 3 is an invaluable companion for any undergraduate throughout their studies in molecular genetics.
Genomes 3 builds on the achievements of the previous editions putting genomes, rather than genes, at the center of molecular genetics teaching. Recognizing that molecular biology research was being driven more by genome sequencing and functional analysis than by research into genes, this approach has gathered momentum in recent years.
The new edition has been significantly restructured and updated to incorporate recent major advances.
Key...
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A Short Guide to the Human Genome
by Stewart Scherer (Author)
How many genes are in the human genome? Which genes are commonly associated with genetic diseases? How many mobile elements, simple sequence repeats, or protein kinases are encoded in the genome? What are the largest genes and proteins? How similar are human proteins to those of mouse, yeast, or bacteria?
Although the human genome has been sequenced, it often can be surprisingly difficult to find answers to seemingly simple questions about its characteristics. This convenient handbook, written in question-and-answer format, allows researchers and teachers alike access to basic facts about the human genome.
Using a recent assembly of the human genome sequence, Stewart Scherer has compiled answers to a broad range of questions about the structure and function of the human...
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Genomes and What to Make of Them
by Barry Barnes (Author), John Dupre (Author)
The announcement in 2003 that the Human Genome Project had completed its map of the entire human genome was heralded as a stunning scientific breakthrough: our first full picture of the basic building blocks of human life. Since then, boasts about the benefits—and warnings of the dangers—of genomics have remained front-page news, with everyone agreeing that genomics has the potential to radically alter life as we know it. For the nonscientist, the claims and counterclaims are dizzying—what does it really mean to understand the genome? Barry Barnes and John Dupré offer an answer to that question and much more in Genomes and What to Make of Them, a clear and lively account of the genomic revolution and its promise. The book opens with a brief history of the science of genetics and...
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A Primer of Genome Science, Third Edition
by Gibson (Author), Muse (Author)
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The Genome War: How Craig Venter Tried to Capture the Code of Life and Save the World
by James Shreeve (Author)
The long-awaited story of the science, the business, the politics, the intrigue behind the scenes of the most ferocious competition in the history of modern science—the race to map the human genome. On May 10, 1998, biologist Craig Venter, director of the Institute for Genomic Research, announced that he was forming a private company that within three years would unravel the complete genetic code of human life—seven years before the projected finish of the U.S. government’s Human Genome Project. Venter hoped that by decoding the genome ahead of schedule, he would speed up the pace of biomedical research and save the lives of thousands of people. He also hoped to become very famous and very rich. Calling his company Celera (from the Latin for “speed”), he assembled a small...
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Welcome to the Genome: A User's Guide to the Genetic Past, Present, and Future
by Rob DeSalle (Author), Michael Yudell (Author), American Museum of Natural History (Author)
A thrilling "user's guide" to the genomics era Welcome to the genome, the miraculous blueprint of your DNA, coiled tight as a spring in the nucleus of each cell of your body. If unwound, the DNA from just one cell, while only a molecule in width, would stretch six feet in length! The information stored in its double helix structure - three billion bits worth - could fill 142 Manhattan phone books. Yet far more amazing than these facts is the impact the study of genomics has had on so many areas of our lives. From the promise of personalized medicine and gene therapy to disputes over the safety of genetically modified (GM) foods, there is little doubt we are in the midst of the Genomic Revolution. Now how do we make sense of it all? Welcome to the Genome takes...
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A Life Decoded: My Genome: My Life
by J. Craig Venter (Author)
The triumphant memoir of the man behind one of the greatest feats in scientific history
Of all the scientific achievements of the past century, perhaps none can match the deciphering of the human genetic code, both for its technical brilliance and for its implications for our future. In A Life Decoded, J. Craig Venter traces his rise from an uninspired student to one of the most fascinating and controversial figures in science today. Here, Venter relates the unparalleled drama of the quest to decode the human genome—a goal he predicted he could achieve years earlier and more cheaply than the government-sponsored Human Genome Project, and one that he fulfilled in 2001. A thrilling story of detection, A Life Decoded is also a revealing, and often troubling, look at how science is...
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A Primer of Genome Science, 2nd Edition
by Greg Gibson (Author), Spencer V. Muse (Author)
A Primer of Genome Science bridges the gap between standard genetics textbooks and highly specialized, technical, and advanced treatments of the subdisciplines. It provides an affordable and up-to-date introduction to the field that is suited to advanced undergraduate or early graduate courses. Bioinformatic principles and experimental strategies are explained side-by-side with the experimental methods, establishing a framework that allows teachers to explore topics and the literature at their own pace.
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