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New technology may prevent vitamin B12 deficient seniors and vegetarians from needing injections
June 18, 2008For those patients who receive the nearly 40 million intramuscular injections per year to treat their B12 deficiency, a new oral option may soon exist.
According to the National Institutes of Health, vitamin B12 deficiency can lead to a wide spectrum of conditions, such as anemia, dementia and reduced cognitive functioning. Vitamin B12 deficiency is a significant health issue. Nearly 40 percent of the U.S. population is B12 deficient (Tufts University, Boston). This includes a sizable number of patients who are severely deficient and are currently being treated. Further, a vast number of people are completely unaware they are B12 deficient and will eventually need treatment. Seniors and strict vegetarians are most at risk. Symptoms such as fatigue, constipation, loss of appetite and weight loss can occur in those who are deficient.
"Vitamin B12 is a perfect example of the successful application of our eligen® technology," said Cristina Castelli, Ph. D., AAPS expert and lead researcher at Emisphere Technologies, Inc. "Our current studies have shown our oral solid formulation brings vitamin B12 absorption to a range of 7-30% without the discomfort of an invasive route of administration."
Ms. Castelli and other project researchers will be at the AAPS National Biotechnology Conference to present and discuss their research with hundreds of pharmaceutical scientists from countries around the world.
Animal testing has been completed and researchers are now conducting human studies.
American Association of Pharmaceutical Scientists
B12 Deficiency Current Events and B12 Deficiency News RSSLow levels of vitamin B12 may increase risk for neural tube defects
Children born to women who have low blood levels of vitamin B12 shortly before and after conception may have an increased risk of a neural tube defect, according to an analysis by researchers at the National Institutes of Health, Trinity College Dublin, and the Health Research Board of Ireland.
Genetic Variants Associated with Vitamin B12
Researchers at the Harvard School of Public Health (HSPH) and their collaborators at Tufts University and the National Cancer Institute (NCI) have identified a common genetic influence on B12 vitamin levels in the blood, suggesting a new way to approach the biological connections between an important biochemical variable and deficiency-related diseases.
Vitamin B12 function may be diminished by excessive folate
In a study of adults aged 20 and over, researchers at Tufts University showed that homocysteine and methylmalonic acid are at much higher levels in individuals who have a combination of vitamin B12 deficiency and high blood folate levels than in individuals who are also vitamin B12 deficient but have normal folate levels.
Impact of elevated homocysteine levels on vision under study
Homocysteine, an amino acid believed to contribute to heart attack, stroke and dementia, likely also is a player in retinal damage and vision loss, researchers say.
Folate and B12 may influence cognition in seniors
Folate and vitamin B12, two important nutrients for the development of healthy nerves and blood cells, may work together to protect cognitive function among seniors, reports a new epidemiological study from the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA).
Fortifying food with folic acid benefits babies
Adding folic acid to food can dramatically reduce the incidence of spina bifida and other birth defects. A study, published today in BMC Pregnancy and Childbirth, shows that the proportion of babies born with neural tube defects in the province of Newfoundland and Labrador dropped by 78% after the Canadian Government directed that folic acid must be added to flour, cornmeal and pasta. The study supports the continuation of this food fortification strategy.
Detecting vitamin B12 deficiency prevents anaemia and memory loss
Vitamin B12 is essential to human life. The body cannot make its own supplies and without an adequate dietary supply from animal sources or enriched cereals, up to 20 million people can suffer anaemia, risk nerve damage and even death. Unfortunately, vitamin B12 deficiency can go undetected for several years, remaining invisible to doctors while the likelihood of irreversible cell damage increases. Under EUREKA project E! 2263 HOLOTC, Norwegian diagnostics company Axis Shield teamed up with Danish academics to find a way to pick up early warning signs of potentially harmful B12 deficits. The project pioneered a unique B12 detection system, which tracks concentrations of holotc (short for ho
LAUGHING GAS - A FASHIONABLE RECREATIONAL DRUG? (p 1347)
Issue 19 April 2003 Embargoed 0001 h (London time) 18 April 2003 New Zealand authors of a research letter in this week's issue of THE LANCET report how laughing gas may be a popular recreational drug among young people. This could have implications for public health, as a case report in THE LANCET last year highlighted how excessive use of nitrous oxide ('laughing gas') caused spinal degeneration in a frequent user of the drug. In a questionnaire-based study, Richard Frith from Auckland Hospital, New Zealand, and colleagues surveyed 1782 students in their first year at the University of Auckland. Just under 60% of students who responded were aware of the use of nitrous oxide for recreation
More B12 Deficiency Current Events and B12 Deficiency News Articles
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Could It Be B12?: An Epidemic of Misdiagnoses by Sally M. Pacholok RN (Author), Jeffrey J. Stuart DO (Author) In Could It Be B12?, RN Sally M. Pacholok and her physician husband, Jeffrey J. Stuart, cite the extensive research done by numerous medical centers and universities that proves B12 deficiency plays a defining role in many seemingly hopeless problems. Yet, even in the face of these studies, this disorder has somehow been overlooked by the general medical field and is often misdiagnosed. The authors include numerous case histories and offer their readers strategies on how to learn if they or a loved one may be suffering from a B12 deficiency. |
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Pernicious Amemia Folic Acid B-12 Deficiency Photographic Poster Print, 16x12 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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Liquid B-12 Complex - 2 oz - Liquid by Now Foods Vitamin B-12 (Cyanocobalamin) is a water-soluble vitamin necessary for the maintenance of a healthy nervous system and for the metabolic utilization of fats and proteins. Vitamin B-12 is also essential for the synthesis of DNA during cell division and therefore is especially important for rapidly multiplying cells, such as blood cells. In addition, adequate intake of Vitamin B-12, along with Folic Acid and Vitamin B-6, encourages healthy serum homocysteine levels, thereby supporting cardiovascular health. Because Vitamin B-12 is found only in animal products, strict vegetarians are at risk of developing Vitamin B-12 deficiency and may benefit from supplementation.* From the FDA's website: "As part of a well-balanced diet that is low in saturated fat and cholesterol, Vitamin B12 may... |
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B12 Vitamin Deficiency Home Collection Urine Test Kit UMMA based Vitamin B12 Deficiency Detection Kit is an accurate, specific sensitive, cost-effective and easy-to-use screening kit that can be used at the convenience of your home to screen samples for Vitamin B12 (cobalamin) deficiency. Explicitly, this kit measures methylmalonic acid (MMA) i.e. a compound produced in very small amounts during amino acid metabolism, in urine samples. Increased amount of MMA in urine serves as a sensitive and early indicator of vitamin B12 deficiency. |
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Vitamin B12 Deficiency (Round Table) by Victor Herbert (Editor) | |
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Pernicious Amemia Folic Acid B-12 Deficiency Photographic Poster Print, 40x30 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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Advances in Thomas Addisons Diseases- 2 Volume Set (volume 1: clinical devolopments in adrenal cortical disiese and Vitamin b12 deficiency; volume 2; biochemical Studies and pathophysiology of adrenal cortex and vitamin b12) by thomas addison society journal of endocrinology limited (Publisher) | |
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Pernicious Amemia Folic Acid B-12 Deficiency Photographic Poster Print, 32x24 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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Vitamin [B.sub.12] deficiency can escape detection; elderly at risk.(Clinical Rounds): An article from: Internal Medicine News by Mitchell L. Zoler (Author) This digital document is an article from Internal Medicine News, published by International Medical News Group on October 1, 2003. The length of the article is 417 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Vitamin [B.sub.12] deficiency can escape detection; elderly at risk.(Clinical Rounds) Author: Mitchell L. Zoler Publication: Internal Medicine News (Magazine/Journal) Date: October 1, 2003 Publisher: International Medical News Group Volume: 36 Issue: 19 Page: 23(1) Distributed by Thomson... | |
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Pernicious Amemia Folic Acid B-12 Deficiency Photographic Poster Print, 40x30 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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