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Evalve MitraClip: Clinical trial of nonsurgical repair for severe mitral valve regurgitation
June 19, 2008The Cedars-Sinai Heart Institute is the lead enroller in the world for the Everest II Clinical Trial - a study comparing non-surgical repair for severe mitral valve regurgitation with conventional surgery. In 2005, a team of doctors at the Institute implanted the first Evalve MitraClip™ in California, and was also first on the West Coast to insert two clips during a single procedure. Cedars-Sinai is believed to be the most experienced center in the nation with any form of percutaneous mitral valve repair.
About four million Americans have significant mitral valve regurgitation, with 250,000 new patients diagnosed each year.
The mitral valve consists of two "leaflets" that act as swinging doors between the left atrium and the left ventricle. If the valve fails to close properly, blood flows backward into the atrium (regurgitation), leaving the left ventricle, the heart's primary pumping chamber, with too little blood. To compensate, the ventricle stretches and overworks. Over time, it undergoes a process called remodeling, becoming enlarged, distorted and weak.
The MitraClip procedure is performed in a cardiac catheterization laboratory with the patient under general anesthesia. A thin, flexible tube (catheter) is inserted through a small incision in the groin and guided through the femoral vein to the affected area of the heart. A smaller catheter holding the clip is slipped through the first catheter. After the clip is attached to the valve leaflets, the catheters are removed. The patient is released from the hospital within a day or two.
While the procedure is complex and challenging, requiring a coordinated effort among echocardiographers, interventional cardiologists, anesthesiologists and other team members, it is also somewhat forgiving. If the clip is not placed ideally on the first attempt, it can be reset. If it does not sufficiently correct the regurgitation, surgical repair or replacement of the valve remains an option.
Results from studies so far show that the MitraClip can provide successful reduction of mitral regurgitation for up to 36 months. Also, studies showed that with resumption of proper valve function, left ventricular remodeling was significantly improved at 12-month follow-up.
Traditional surgery is still the best option in extremely difficult cases or when the annulus, the ring-shaped structure to which the leaflets are attached, needs repair. Cedars-Sinai's Center for Valvular Intervention, one of the largest heart valve programs in the western United States, combines the expertise of cardiologists and cardiothoracic surgeons to offer a wide range of surgical and non-surgical repair and replacement procedures.
Cedars-Sinai Medical Center
The MitraClip procedure is performed in a cardiac catheterization laboratory with the patient under general anesthesia. A thin, flexible tube (catheter) is inserted through a small incision in the groin and guided through the femoral vein to the affected area of the heart. A smaller catheter holding the clip is slipped through the first catheter. After the clip is attached to the valve leaflets, the catheters are removed. The patient is released from the hospital within a day or two.
While the procedure is complex and challenging, requiring a coordinated effort among echocardiographers, interventional cardiologists, anesthesiologists and other team members, it is also somewhat forgiving. If the clip is not placed ideally on the first attempt, it can be reset. If it does not sufficiently correct the regurgitation, surgical repair or replacement of the valve remains an option.
Results from studies so far show that the MitraClip can provide successful reduction of mitral regurgitation for up to 36 months. Also, studies showed that with resumption of proper valve function, left ventricular remodeling was significantly improved at 12-month follow-up.
Traditional surgery is still the best option in extremely difficult cases or when the annulus, the ring-shaped structure to which the leaflets are attached, needs repair. Cedars-Sinai's Center for Valvular Intervention, one of the largest heart valve programs in the western United States, combines the expertise of cardiologists and cardiothoracic surgeons to offer a wide range of surgical and non-surgical repair and replacement procedures.
Cedars-Sinai Medical Center
Study details safe, effective, minimally invasive mitral valve repair
Surgical treatment for mitral valve disease includes either repairing the patient's diseased valve or replacing it with a metal, mechanical valve or an animal tissue valve.
Half of eligible patients not getting mitral valve surgery, U-M study shows
Overblown fears about surgical risk and lack of awareness about the risk of not operating are among the reasons only half of eligible patients were referred for mitral valve repair, according to a study by doctors at the University of Michigan Cardiovascular Center.
Mount Sinai first in US to implant FDA-cleared ring for mitral valve repair
David H. Adams, MD, Marie-Josée and Henry R. Kravis Professor and Chairman of the Department of Cardiothoracic Surgery at The Mount Sinai Medical Center, performed the first two implantations of the Carpentier-Edwards Physio II ring in the United States yesterday.
ESC Congress 2003: Cough for your life
IMPORTANT: This press release accompanies both a presentation and an ESC press conference given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology ESC Congress 2003: Cold comfort - Cough for your life Background of the study: Sudden Cardiac Death (SCD) is defined as death resulting from sudden, abrupt, loss of heart function resulting from disturbances of cardiac rhythm (arrhythmias) in a person who may, or may not have been diagnosed with heart disease. It occurs dramatically, instantly or shortly after symptoms appear. Most SCD episodes are ultimately caused by ventricular
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Mitral valve regurgitation repair made easier with new device: the innovative catheter-based procedure means more patients may soon find relief from a ... An article from: Heart Advisor by Unavailable (Author) This digital document is an article from Heart Advisor, published by Belvoir Media Group, LLC on April 1, 2009. The length of the article is 650 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. Citation Details Title: Mitral valve regurgitation repair made easier with new device: the innovative catheter-based procedure means more patients may soon find relief from a common heart valve ailment.(BREAKTHROUGHS) Author: Unavailable Publication: Heart Advisor (Magazine/Journal) Date: April 1, 2009 Publisher: Belvoir Media Group, LLC Volume: 12 Issue: 4 Page: 3(1) Distributed by Gale, a part of Cengage... | |
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Mitral Valve: Floppy Mitral Valve, Mitral Valve Prolapse, Mitral Valvular Regurgitation by Harisios Boudoulas M.D. Ph.D. (Editor), M.D., Charles Wooley (Editor) Few cardiac disorders have generated as much controversy and discussion over the last two centuries as the floppy mitral valve (FV)/ mitral valve prolapse (MVP)/ mitral valvular regurgitation (MVR) triad, and the mitral valve prolapse syndrome. During the past 50 years, recognition of its broad pathologic and clinical spectrum has led to the appreciation of the FV as the central issue in the FV/MVP/MVR story. Accordingly, the clinical phenomena and imaging characteristics inherent in the FV/MVP/MVR triad will be best understood when reconciled with the gross morphologic, histopathologic, and molecular characteristics of the FV complex. This book is written to cover the entire spectrum of FV and its sequelae. The inheritance patterns, genetic studies, and development of family... |
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Predictive value of cardiothoracic ratio as a marker of severity of aortic regurgitation and mitral regurgitation/Kardiyotorasik oranin aort yetersizligi ... of Cardiology (Anadolu Kardiyoloji Dergisi) by Funda Oztunc (Author), Kadir Babaoglu (Author), Elif Yilmaz (Author), Tevfik Demir (Author), Gulay Ahunbay (Author) This digital document is an article from The Anatolian Journal of Cardiology (Anadolu Kardiyoloji Dergisi), published by Thomson Gale on June 1, 2007. The length of the article is 3240 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Predictive value of cardiothoracic ratio as a marker of severity of aortic regurgitation and mitral regurgitation/Kardiyotorasik oranin aort yetersizligi ve mitral yetersizligi derecesini ongormedeki guvenilirligi.(Original Investigation/Orijinal Arastirma)(Clinical report) Author: Funda Oztunc Publication: The Anatolian Journal of Cardiology... | |
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Valvular Heart Disease (Contemporary Cardiology) by Andrew Wang (Editor), Thomas M. Bashore (Editor) Challenges for the treatment of valvular heart disease include the growing need for effective yet less invasive interventions and therapies to treat these progressive conditions. With the development of potential new treatments, it is crucial for cardiac |
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