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First gene therapy for heart failure offered at NewYork-Presbyterian/Columbia
June 19, 2008Could injecting a gene into a patient with severe heart failure reverse their disabling and life-threatening condition? Physician-scientists are setting out to answer that question in a first-ever clinical trial of gene therapy to treat severe heart failure.
NewYork-Presbyterian Hospital/Columbia University Medical Center is the only center in the New York City area where the therapy is currently available.
"This new therapy seeks to replenish the levels of this enzyme by introducing the gene for SERCA2a, which is depressed in these patients. If proven effective, this approach could be an alternative to heart transplant for patients without any other options," says Dr. Donna Mancini, the study's principal investigator at NewYork-Presbyterian Hospital/Columbia University Medical Center, where she is medical director of cardiac transplantation. She also is professor of medicine at Columbia University College of Physicians and Surgeons.
Gene therapy is a technique for correcting defective genes responsible for disease development by inserting genes into a patient's cells and tissues. In most gene therapy studies, a "normal" gene is inserted into the genome to replace an "abnormal" disease-causing gene. A carrier molecule called a vector must be used to deliver the therapeutic gene to the patient's target cells. Currently, the most common vector is a non-pathogenic virus most people have been exposed to in adolescence that has been genetically altered to carry normal human DNA.
More than five million people in the U.S. have heart failure. Patients with severe form of the disease have trouble breathing because the heart cannot pump fluid out of their lungs. Seventy percent die of the disease within 10 years, and the five-year survival rate is less than 50 percent. Heart failure is the only cardiovascular disease whose incidence has been increasing rather than decreasing.
New York- Presbyterian Hospital/Columbia University Medical Center
Heart Failure Current Events and Heart Failure News RSSInhibition of GRK2 is protective against acute cardiac stress injuries
Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion.
Young athletes need dual screening tests for heart defects, study suggests
To best detect early signs of life-threatening heart defects in young athletes, screening programs should include both popular diagnostic tests, not just one of them, according to new research from heart experts at Johns Hopkins.
Protein changes in heart strengthen link between Alzheimer's disease and chronic heart failure
A team of U.S., Canadian and Italian scientists led by researchers at Johns Hopkins report evidence from studies in animals and humans supporting a link between Alzheimer's disease and chronic heart failure, two of the 10 leading causes of death in the United States.
Elevated biomarkers lead to diminished quality of life in heart attack patients post-discharge
Many heart attack patients have high levels of cardiac biomarkers in the blood for several months after leaving the hospital, with more shortness of breath and chest pain, according to a Henry Ford Hospital study.
Tiny particles can deliver antioxidant enzyme to injured heart cells
Researchers at Emory University and the Georgia Institute of Technology have developed microscopic polymer beads that can deliver an antioxidant enzyme made naturally by the body into the heart.
New study links vitamin D deficiency to cardiovascular disease and death
While mothers have known that feeding their kids milk builds strong bones, a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong and healthy heart as well - and that inadequate levels of the vitamin may significantly increase a person's risk of stroke, heart disease, and death, even among people who've never had heart disease.
When seconds count: Interventional radiology treatment for pulmonary embolism saves lives
Catheter-directed therapy or catheter-directed thrombolysis-an interventional radiology treatment that uses targeted image-guided drug delivery with specially designed catheters to dissolve dangerous blood clots in the lungs-saves lives and should be considered a first-line treatment option for massive pulmonary embolism, note researchers in the November Journal of Vascular and Interventional Radiology.
Texas Children's discharges first pediatric patient with implanted mechanical heart device
Texas Children's Hospital is the nation's first pediatric hospital to discharge a child while on an intracorporeal ventricular assist device (VAD), a feat previously accomplished only at adult institutions.
Researchers develop innovative imaging system to study sudden cardiac arrest
A research team at Vanderbilt University has developed an innovative optical system to simultaneously image electrical activity and metabolic properties in the same region of a heart, to study the complex mechanisms that lead to sudden cardiac arrest.
Experts unveil new CVD guidelines and position papers
Several new guidelines and position papers offering the most up to date information to ensure that clinicians practice evidence-based medicine were released at the Canadian Cardiovascular Congress 2009 this week.
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Success with Heart Failure (mass mkt ed): Help and Hope for Those with Congestive Heart Failure by Marc Silver (Author) Up-to-date information on available and forthcoming medical and surgical treatments. How attitude and emotion affect heart failure--and what you can do to stay positive. Tips for adopting a heart-healthy diet and lifestyle. Ways to forge a positive working relationship with your doctor or cardiologist. |
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The Cleveland Clinic Guide to Heart Failure (Cleveland Clinic Guides) by Randall Starling (Author) Expert medical advice from the #1 heart center in America for 14 years in a row
For the 5 million people with heart failure, there’s new reason for hope: recent medical advances have revolutionized how this condition is managed.
In The Cleveland Clinic Guide to Heart Failure, Dr. Randall Starling, one of the foremost authorities on heart health, provides authoritative advice to help people survive heart failure and enjoy a good quality of life. This comprehensive resource gives readers the cutting-edge medical guidance Dr. Starling offers his patients, including:
* Insight into what causes heart failure * The latest breakthrough studies – and what those discoveries mean for the future of this disease * Reliable guidance on diagnostic tests and treatment... |
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Heart Failure: Pathophysiology, Molecular Biology, and Clinical Management (HEART FAILURE: PATHOPHYSIOLOGY, MOLEC BIOL & CLIN MGT) by Arnold M Katz (Author), Marvin A Konstam (Author) This Second Edition of Dr. Katz's highly acclaimed text has been thoroughly revised to incorporate the latest advances in the study and treatment of heart failure. The book explains the pathophysiology, molecular mechanisms, clinical manifestations, and therapy of heart failure in an integrated, reader-friendly manner that is accessible to both clinicians and basic scientists. More than 100 illustrations, most created for this book by the authors, complement the text. This edition has been completely reorganized. Chapters describe the hemodynamic basis for the clinical manifestations of heart failure; the neurohumoral responses in heart failure and key signaling pathways that mediate functional responses; the proliferative responses in failing hearts; the cellular and molecular... |
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Manual of Heart Failure Management by John. D Bisognano (Editor), Marc. L. Baker (Editor), Mary Beth Earley (Editor) Heart failure is an increasingly common occurance in the patient population despite better treatment and management options available to clinicians. The focus is now increasingly turning towards prevention to reduce the rising incidence in addition to more efficacious treatment regimens. With emphasis on practical knowledge and easy reference, this title is designed to present the relevant diagnostic, management and treatment information in an easily digested and evidence-based algorithm format. With use of illustrations, readers will be able to rely on this text as a basic primer when studying patients with this complex and multifaceted set of diseases. |
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ABC of Heart Failure (ABC Series) by Russell C. Davis (Author), Michael K. Davies (Author), Gregory Y. H. Lip (Author) This new edition of the ABC of Heart Failure provides coherent and concise information relating to the epidemiology, pathophysiology and clinical features, aiding the diagnosis and treatment of this life threatening condition. Fully updated to cover all the latest advances, the ABC of Heart Failure is an invaluable reference for general practitioners, hospital doctors, nurses and other healthcare professionals involved in the treatment and prevention of heart failure. |
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Heart Failure Heart failure, also called congestive heart failure, is a condition in which the heart cannot pump enough oxygenated blood to meet the needs of the body?s other organs. The heart keeps pumping, but not as efficiently as a healthy heart. Usually, the loss in the heart?s pumping action is a symptom of an underlying heart problem. Heart failure affects nearly 5 million US adults. It is on the rise with an estimated 400,000 to 700,000 new cases each year. This talk will focus on the causes, symptoms, diagnosis and treatments available for heart failure, including current research findings from Stanford. |
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FlameEz-Heart, 60 Capsules/Bottle by FlameEz Conditions that damage the heart muscle or make it work too hard can cause heart failure. Over time, the heart weakens and certain inflammatory substances may be released into the blood, which have a toxic effect on the heart and cause heart failure to worsen. The most common causes of heart failure are coronary artery disease, high blood pressure, and diabetes, all of which are associated with chronic inflammation. Inflammatory cytokines suppress heart contractility, initiate hypertrophy and promote cell death or fibrosis. Results from a recent study land additional support that obesity causes prolonged inflammation of heart tissue that in turn boosts heart failure risk. New studies also suggest that modulation of inflammatory and immune responses may offer some hope to improve heart... |
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Holy Heart Failure by Holy Heart Failure | |
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Heart Failure: A Practical Approach to Treatment by William Abraham (Author), Henry Krum (Author) The definitive one-stop guide to treating -- and preventing -- heart failure This practical reference provides all the expert guidance and up-to-the-minute clinical perspectives you need to diagnose, treat, and manage patients with heart failure. A major focus of the book is integration of various management approaches to maximize patient benefit. Coverage begins with a brief introduction to the incidence and causes of heart failure, then quickly moves into a more thorough clinical overview of symptom evaluation, pharmacologic and non-pharmacologic treatment methods, hospitalization, surgical treatments, and more. Features: Clear, step-by-step coverage of prevention and all treatment modalities with evidence-based recommendations Full... |
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Pathophysiology For Nurses: Heart Failure and Pulmonary Edema (VHS) Also With: Mosby (Producer) |
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