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Systems properties of insulin signaling revealed
June 20, 2008A team of Swedish researchers has characterized novel systems properties of insulin signaling in human fat cells. Their mathematical modeling, described in an article published June 20th in the open-access journal PLoS Computational Biology, provides further insight into energy level maintenance (via the hormone insulin) within our bodies.
Hampered insulin function is the cardinal cause of Type 2 diabetes, which currently affects nearly 250 million people worldwide. The disease causes a metabolic malfunction due to incorrect information transfer of insulin concentration in the blood to the internal fluid of cells (the cytosol). This information transfer occurs through a complicated network of protein-protein interactions. The skeleton of the network has been characterized, but systems details, including the relative importance and time-scales of the interactions, were previously unknown.
Due to the complexity of the network, it has proved difficult to achieve such a systems understanding through mere experimental techniques and reasoning. Therefore, the team experimentally collected time-series data from human fat cells in vitro and evaluated various mechanistic explanations by translating the explanations into corresponding mathematical models.
In this study, the modeling indicated that either receptor recycling between the membrane and the cytosol, or feedback from proteins activated further down in the network, are involved in the information transfer during the first minutes after insulin stimulation.
As more detailed data become available, the authors predict that mathematical modeling will become an increasingly important tool for data analysis, and for furthering understanding of insulin signaling and cellular control.
Public Library of Science
In this study, the modeling indicated that either receptor recycling between the membrane and the cytosol, or feedback from proteins activated further down in the network, are involved in the information transfer during the first minutes after insulin stimulation.
As more detailed data become available, the authors predict that mathematical modeling will become an increasingly important tool for data analysis, and for furthering understanding of insulin signaling and cellular control.
Public Library of Science
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A team led by scientists at The Scripps Research Institute have discovered a direct link between insulin-a hormone long associated with metabolism and metabolic disorders such as diabetes-and core body temperature.
Scientists find molecular trigger that helps prevent aging and disease
Researchers at Mount Sinai School of Medicine set out to address a question that has been challenging scientists for years: How do dietary restriction-and the reverse, overconsumption-produce protective effects against aging and disease?
Fat collections linked to decreased heart function
Researchers from Boston University School of Medicine (BUSM) have shown that fat collection in different body locations, such as around the heart and the aorta and within the liver, are associated with certain decreased heart functions.
Researchers discover mechanism of insulin production that can lead to better treatment for diabetes
How a specific gene within the pancreas affects secretion of insulin has been discovered by researchers from the Hebrew University of Jerusalem, in collaboration with Japanese and American universities.
Curry-cure? Spicing up the effectiveness of a potential disease-fighter
Scientists are reporting development of a nano-size capsule that boosts the body's uptake of curcumin, an ingredient in yellow curry now being evaluated in clinical trials for treatment of several diseases.
Postmenopausal women with higher testosterone levels
Postmenopausal women who have higher testosterone levels may be at greater risk of heart disease, insulin resistance and the metabolic syndrome compared to women with lower testosterone levels.
New scientific study indicates that eating quickly is associated with overeating
According to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), eating a meal quickly, as compared to slowly, curtails the release of hormones in the gut that induce feelings of being full.
AAP supports the IDF guideline on oral health for people with diabetes
New clinical guidelines released by the International Diabetes Foundation (IDF) emphasize the importance of periodontal health for people with diabetes.
Study: Lap band surgery effective for morbidly obese children
A surgeon at Children's National Medical Center and his colleagues from New York University have found laparoscopic adjustable gastric banding (Lap band) to improve the health of morbidly obese adolescents.
UM Scientists Create Fruit Fly Model to Help Unravel Genetics of Human Diabetes
As rates of obesity, diabetes, and related disorders have reached epidemic proportions in the US in recent years, scientists are working from many angles to pinpoint the causes and contributing factors involved in this public health crisis.
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