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Smoking out the mediators of airway damage caused by pollutants
June 23, 2008New insight into how pollution and cigarette smoke damage airways has been provided by Pierangelo Geppetti and colleagues, at the University of Florence, Italy, who studied the effects of such chemicals on guinea pig airways.
As discussed, in an accompanying commentary, by Sidney Simon and Wolfgang Liedtke, at Duke University Medical Center, it is hoped that this information will help in the development of therapeutics to combat the effects of pollutants and perhaps help individuals with smoke-related diseases such as chronic obstructive pulmonary disease and chronic asthma.
In the study, chemicals found in cigarette smoke were shown to activate signaling in nerves that ended in the airways of guinea pigs. These effects were abolished using a molecule that inhibited a protein known as TRPA1. Consistent with a central role for TRPA1 in sensing chemicals in cigarette smoke, no signaling in nerves that end in the airways was observed in mice lacking TRPA1 after exposure to the chemicals in cigarette smoke. Further analysis showed that alpha,beta-unsaturated aldehydes were the chemicals that activated TRPA1, suggesting that they might contribute to the airway damage that occurs in smoke-related diseases.
Journal of Clinical Investigation
Journal of Clinical Investigation
Cigarette Smoke Current Events and Cigarette Smoke News RSSSmokers with common autoimmune disorder at higher risk for skin damage
As if there weren't enough reasons to stop smoking, a team of researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) have just found another.
Injury and hazards in home health care nursing are a growing concern
Patients continue to enter home healthcare ''sicker and quicker," often with complex health problems that may require extensive nursing care.
Second-hand smoking results in liver disease, study finds
A team of scientists at the University of California, Riverside has found that even second-hand tobacco smoke exposure can result in nonalcoholic fatty liver disease (NAFLD), a common disease and rising cause of chronic liver injury in which fat accumulates in the liver of people who drink little or no alcohol.
New genes at work in patients with hereditary lung disease
University of Florida researchers have safely given new, functional genes to patients with a hereditary defect that can lead to fatal lung and liver diseases, according to clinical trial findings slated to appear this week in the online early edition of the Proceedings of the National Academy of Sciences.
New genes at work in patients with hereditary lung disease
Researchers at the University of Massachusetts Medical School and the University of Florida in Gainesville have safely given new, functional genes to patients with a hereditary defect that can lead to fatal lung and liver diseases.
Growing evidence of marijuana smoke's potential dangers
In a finding that challenges the increasingly popular belief that smoking marijuana is less harmful to health than smoking tobacco, researchers in Canada are reporting that smoking marijuana, like smoking tobacco, has toxic effects on cells.
Unlocking the key to human fertility
Scientists at Leeds and Bradford have discovered a unique 'DNA signature' in human sperm, which may act as a key that unlocks an egg's fertility and triggers new life.
Scientists open doors to diagnosis of emphysema
Chronic inflammatory lung diseases like chronic bronchitis and emphysema are a major global health problem, and the fourth leading cause of death and disability in developed countries, with smoking accounting for 90% of the risk for developing them.
'Cannabis alters human DNA' -- new study
A new study published by University of Leicester researchers has found "convincing evidence" that cannabis smoke damages DNA in ways that could potentially increase the risk of cancer development in humans.
Top notch decisions in the developing airways bring insights into lung disease
In the normal lung, the airways are lined by a balanced mixture of ciliated, secretory and neuroendocrine cells which perform functions as diverse as air humidification, detoxification, and clearance of environmental particles.
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Gray 43" Outdoor Ashtray Cigarette Butt Receptacle Weatherproof Commercial by Commercial Zone This is one great little outdoor ashtray. It is made of extemely tough plastic which you would think would melt with hot cig butts going in. But no! It has a METAL bucket in the bottom to catch the butts. It doesn't need sand either as this design snuffs the butt out by restricting air to it. This ashtray stands 43" tall and has a 12" wide base making it easy to place just about anywhere you need it. Compare this height to other shorter units that smokers have to bend over to use. Really cleans up the smoking area. No more cigarette butts all over the ground! Very easy to assemble, no screws or other hardware and certainly no tools needed. It just snaps together. It also has small holes at the bottom for hold downs or whatever type you prefer to keep it in one place. Great around a... |
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WHAT A FAG smoke uk british cigarette sexuality SHIRT by TS Threads Brand New Never Been Worn. What a Fag Shirt. Sizes Available: Youth Small - Adult 6XL Mention the size you want within your payment. |
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Zippo Lighter - Pewter Emblem Maltese Cross - Zippo Lighter by Siskiyou Start something with this precision-crafted pewter emblem on America's most trusted lighter... Zippo. |
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Classic BYU Tobacco Use & Industry Propaganda Film DVD: 1960 BYU LDS Dept. Of Education Tobacco / Cigarette Industry Portrayal Film: [Up In Smoke] This propaganda piece lobbies against big tobacco and portrays the tobacco industry as a lying, greedy, and cutthroat business that knowingly hides the truth about the health problems caused by smoking cigarettes. Table Of Contents: (1) Up In Smoke (1960) - BYU LDS Department of Education sponsored film that attacks the tobacco industry. This surprisingly progressive film portrays the tobacco industry as greedy and participating in deceitful advertising aimed at American youth. "I want ads in every Boy Scout magazine," says the big Tobacco boss of the fictitious cigarette company JB, which sells Humbar Cigarettes. When the CEO's son raises the health issues associated with smoking, he describes it as "nonsense" and explains that he is responsibility to the shareholder; all he does is just... |
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TarGard Mini Disposable Cigarette Filters: Bulk Bag of 100 filters by Venturi Reduce tar and nicotine without changing the taste of your cigarette. Each pack of Mini Filters contains 30 individual filters. This filter is hassle free -- just use and toss! |
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Carrying Case for E-cigarette / Electronic Cigarette for Smoking Liberty Super, Njoy Npro, Smoking Everywhere Gold, Cloud9,& Smoke 51 Trio E-cigarette,fits Also the Original.black Color. by E-Cigarette carrying case. SIZE: 31/2" X 21/2" |
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Smoke Stand Cigarette Receptacle - Silver by SHOPZEUS Overview Sleek and attractive cigarette receptacle is designed to complement the decor of any facility. A clean, modern look keeps cigarette waste out of sight and hidden from public view. Never look at messy cigarette litter again. Easy to clean and maintain. Perfect for entrances, break-areas or any place smokers gather. Specifications41" height makes extinguishing cigarette waste easy Internal cigarette snuffer keeps outside appearance ash-free Powder-coated finish for year-round, outdoor use Easy to clean and maintain; just empty on a regular basis Powder-coated aluminum and steel construction Color: Silver |
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