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Smoking out the mediators of airway damage caused by pollutants
June 23, 2008New insight into how pollution and cigarette smoke damage airways has been provided by Pierangelo Geppetti and colleagues, at the University of Florence, Italy, who studied the effects of such chemicals on guinea pig airways.
As discussed, in an accompanying commentary, by Sidney Simon and Wolfgang Liedtke, at Duke University Medical Center, it is hoped that this information will help in the development of therapeutics to combat the effects of pollutants and perhaps help individuals with smoke-related diseases such as chronic obstructive pulmonary disease and chronic asthma.
In the study, chemicals found in cigarette smoke were shown to activate signaling in nerves that ended in the airways of guinea pigs. These effects were abolished using a molecule that inhibited a protein known as TRPA1. Consistent with a central role for TRPA1 in sensing chemicals in cigarette smoke, no signaling in nerves that end in the airways was observed in mice lacking TRPA1 after exposure to the chemicals in cigarette smoke. Further analysis showed that alpha,beta-unsaturated aldehydes were the chemicals that activated TRPA1, suggesting that they might contribute to the airway damage that occurs in smoke-related diseases.
Journal of Clinical Investigation
Journal of Clinical Investigation
Cigarette Smoke Current Events and Cigarette Smoke News RSSSmokers with common autoimmune disorder at higher risk for skin damage
As if there weren't enough reasons to stop smoking, a team of researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) have just found another.
Injury and hazards in home health care nursing are a growing concern
Patients continue to enter home healthcare ''sicker and quicker," often with complex health problems that may require extensive nursing care.
Second-hand smoking results in liver disease, study finds
A team of scientists at the University of California, Riverside has found that even second-hand tobacco smoke exposure can result in nonalcoholic fatty liver disease (NAFLD), a common disease and rising cause of chronic liver injury in which fat accumulates in the liver of people who drink little or no alcohol.
New genes at work in patients with hereditary lung disease
University of Florida researchers have safely given new, functional genes to patients with a hereditary defect that can lead to fatal lung and liver diseases, according to clinical trial findings slated to appear this week in the online early edition of the Proceedings of the National Academy of Sciences.
New genes at work in patients with hereditary lung disease
Researchers at the University of Massachusetts Medical School and the University of Florida in Gainesville have safely given new, functional genes to patients with a hereditary defect that can lead to fatal lung and liver diseases.
Growing evidence of marijuana smoke's potential dangers
In a finding that challenges the increasingly popular belief that smoking marijuana is less harmful to health than smoking tobacco, researchers in Canada are reporting that smoking marijuana, like smoking tobacco, has toxic effects on cells.
Unlocking the key to human fertility
Scientists at Leeds and Bradford have discovered a unique 'DNA signature' in human sperm, which may act as a key that unlocks an egg's fertility and triggers new life.
Scientists open doors to diagnosis of emphysema
Chronic inflammatory lung diseases like chronic bronchitis and emphysema are a major global health problem, and the fourth leading cause of death and disability in developed countries, with smoking accounting for 90% of the risk for developing them.
'Cannabis alters human DNA' -- new study
A new study published by University of Leicester researchers has found "convincing evidence" that cannabis smoke damages DNA in ways that could potentially increase the risk of cancer development in humans.
Top notch decisions in the developing airways bring insights into lung disease
In the normal lung, the airways are lined by a balanced mixture of ciliated, secretory and neuroendocrine cells which perform functions as diverse as air humidification, detoxification, and clearance of environmental particles.
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Cigarette Smoke and Oxidative Stress by Barry B. Halliwell (Editor), Henrik E. Poulsen (Editor) The mechanism by which cigarette smoke causes or contributes to inflammatory diseases like chronic obstructive pulmonary disease, cardiovascular disease and cancer remains unclear. Recent developments in our knowledge of cellular signalling suggest that cigarette smoke may cause oxidative stress in cellular systems. The assessment, consequences and possible modulation of these effects are discussed in this book. |
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Smoke 51 Electronic Cigarette Carrying Case-silver Leaf by Smoke 51 Silver leaf case, beautiful for carrying electronic cigarette. Pic does not do it justice. Fits 2 batteries and 2 filters |
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Smoke! Smoke! Smoke! That Cigarette Tex Williams (Primary Contributor) |
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Gone Smoke 21022 Smoke 'n' Odor Eliminator Bullet - 0.6 oz., Set of 8 by Gone Smoke Gone Smoke Smoke n Odor Eliminator Bullet encapsulates odor molecules forever. Dry fine-mist aerosol spray leaves cloths and hair dry, not wet. Gone Smoke is safe on human skin, hair, and all textiles. Eighty quick sprays in each bullet and only four to five are necessary per application. Small package is discreet and can fit inside pocket or purse. Label removable for additional privacy. Do not give up personal freedom for fear of smelling like smoke, food or other odors. |
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Who the F**k Are Arctic Monkeys by Arctic Monkeys UK five-track EP. The follow-up to their record-breaking UK #1 debut album 'Whatever People Say I Am, That's What I'm Not' and includes 'View From The Afternoon' plus four exclusive recordings 'Cigarette Smoker Fiona', 'Despair In The Departure Lounge', 'No Buses' & 'Who The Fuck Are Arctic Monkeys'. Domino. 2006. |
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Envy Electronic Cigarettes' Accessories Lot by Envy Electronic Cigarettes This lot is an $87 value if you were to buy it all on the Envy website. In stead get it all here for only $57.95. That's a 35% discount! |
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VaporPro VP100 Electronic Cigarette Kit- Includes 10 refill cartridiges (menthol flavor) by VaporPro The VaporPro electronic cigarette is an alternative to smoked tobacco products, such as cigarettes, cigars, or pipes. It has the look and feel of a real cigarette but is a battery-powered device that delivers a vaporized nicotine solution. In addition this vapor also provides a physical sensation similar to that of inhaled tobacco smoke, while no tobacco, smoke, or combustion is actually involved in its operation. VaporPro electronic cigarettes contain no adverse chemicals such as tar, carbon monoxide, or other preservatives used in tobacco cigarettes The VaporPro Kit includes: 1 - Atomizer (heating element) 2 - Rechargeable Lithium Batteries 1 - USB charger 1 - A/C adapter 10 - Regular Strength 18 mg nicotine Re-fill Cartridges (each cartridge equal to approximately 5... |
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Windmill Trekker Stormproof Lighter (Black Smoke) by Windmill Windmill Trekker Lighter has all the standard features of Windmill Stormproof Lighters, plus Extra large fuel tank - 4 grams over 1,000 ignitions on single fill, easy grip rubberized case fits easily in hand. Features easy one-handed operation, Piezo electric ignition, water-resistance, flame window, refillable butane gas, flame adjustment and wrist lanyard. Weight 2.5 oz - fuel capacity 4 gram, size 3.7" x 1.2" |
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Gray 43" Outdoor Ashtray Cigarette Butt Receptacle Weatherproof Commercial by Commercial Zone This is one great little outdoor ashtray. It is made of extemely tough plastic which you would think would melt with hot cig butts going in. But no! It has a METAL bucket in the bottom to catch the butts. It doesn't need sand either as this design snuffs the butt out by restricting air to it. This ashtray stands 43" tall and has a 12" wide base making it easy to place just about anywhere you need it. Compare this height to other shorter units that smokers have to bend over to use. Really cleans up the smoking area. No more cigarette butts all over the ground! Very easy to assemble, no screws or other hardware and certainly no tools needed. It just snaps together. It also has small holes at the bottom for hold downs or whatever type you prefer to keep it in one place. Great around a... |
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