Science Current Events | Science News | Brightsurf.com
 

OptiNose presents data on highly effective migraine treatment

June 30, 2008

OptiNose announced today that it presented important new data demonstrating the superior performance of its novel nasal drug delivery device with sumatriptan for the treatment of migraines. The Phase II results indicate that the drug-device combination achieves migraine relief as quickly and efficiently as injections without the discomfort, inconvenience and risk of needle-stick injuries. OptiNose presented the data at the Annual Scientific Meeting of the American Headache Society in Boston.

Headache relief was achieved in 74.3% and 83.8% of patients at 60 minutes and 120 minutes after administration, respectively, and 48.6% of patients remained pain free after 48 hours. The results were statistically significant when compared to the study's placebo group. The study also confirmed earlier Phase I results. In the Phase I study, the OptiNose powder nasal drug delivery device achieved the maximum sumatriptan concentration in the blood at a median time of 20 minutes after administration. This result was comparable to injections and much faster than other intranasal delivery technologies.

"We are excited to develop this new treatment for the approximately 30 million Americans who suffer from migraines," said Per Djupesland, M.D., Ph.D., the study's co-author and Chief Scientific Officer at OptiNose AS. "Our new device combination will offer patients a much-needed alternative to existing, slower-acting nasal inhalers and tablets and painful injections."

The user feedback from patients who participated in the study was also very encouraging. "The majority of the migraine patients found the device to be both comfortable and easy to use." said Dr Djupesland. "We believe that we can offer a unique therapy for migraine sufferers, combining fast relief, low side effects and high user compliance."

Unlike traditional nasal delivery devices, the unique design of the OptiNose device ensures that drug is delivered to target sites throughout the entire nasal cavity, achieving optimal dose delivery while avoiding the risk of drug deposition to the lungs.



OptiNose


Related Nasal Drug Delivery Current Events and Nasal Drug Delivery News Articles


OptiNose's novel intranasal sumatriptan product highly effective in treating migraines
OptiNose, a leader in nasal drug delivery systems, is pleased to announce the publication in Cephalalgia of results from its Phase II clinical study investigating the efficacy and tolerability of its novel, intranasal drug/device product for the treatment of migraine.

New data on highly effective treatment for chronic rhinosinusitis with nasal polyps
OptiNose is pleased to announce the publication of results from its Phase II clinical study investigating the efficacy and tolerability of its novel, intranasal drug/device product for the topical treatment of chronic rhinosinusitis with nasal polyps in Rhinology, the official journal of the International and European Rhinologic Societies.

OptiNose presents new data on highly effective treatment for chronic rhinosinusitis
OptiNose today announced important new results from a Phase II trial of its novel nasal drug delivery device with fluticasone for the treatment of chronic rhinosinusitis.
More Nasal Drug Delivery Current Events and Nasal Drug Delivery News Articles

Drug Permeation Enhancement: Theory and Applications (Drugs and the Pharmaceutical Sciences)

Drug Permeation Enhancement: Theory and Applications (Drugs and the Pharmaceutical Sciences)
by Dean S. Hsieh (Author), Dean Ed. Hsieh (Author)


Providing a comprehensive review of drug permeation enhancement, this reference covers the fundamental aspects of physical and chemical enhancement for the transport of both peptides and nonpeptides through the skin, mucosae, and cornea.;Expanding the frontiers of drug delivery research, drug permeation enhancement details the barrier properties of skin; examines skin penetration enhancers; investigates the transdermal delivery of proteins and peptides by iontophoresis; describes electrically mediated transdermal drug delivery; analyzes obstacles to the transmucosal delivery of peptides and proteins; and discusses ocular peptide absorption mechanisms.;Written by 35 internation authorities working in academia, government, and industry, Drug Permeation Enhancement is for pharmaceutical...

Nasal Drug Delivery: Development and Evaluation of Nasal Formulation

Nasal Drug Delivery: Development and Evaluation of Nasal Formulation
by Basavaraj Nanjwade (Author), Kemy A. Parikh (Author)


Microsphere carrier systems made from the biodegradable polymers have attracted considerable attention for several years in sustained drug delivery. However, the short residence time at the site of absorption could be overcome by coupling bioadhesion characteristics to microspheres and developing bioadhesive microspheres with the help of bioadhesive polymers. Neostigmine Bromide – a cholinesterase inhibitor is widely used for the treatment of Myasthenia Gravis. It is presently marketed in conventional dosage form as a tablet in usual strength of 15-30 mg for peroral route. Extent of absorption of drug through oral route is only 1-2% of 30 mg of administered dose. Hence there is need of novel nasal drug delivery system for the treatment of Myasthenia Gravis. To overcome inherent...

Nasal drug delivery system: Microemulsion as a carrier for intranasal drug delivery system

Nasal drug delivery system: Microemulsion as a carrier for intranasal drug delivery system
by Kumkum Sarangdevot (Author), Bhawani Singh Sonigara (Author), Khem Chand Gupta (Author)


The novel carriers have been exploited through almost all the routes of administration. Many newer carriers are evolving with the advent of technology and the demand of targeted delivery like microemulsions. Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant. These systems are currently of interest because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. In addition to oral and intravenous delivery, they are amenable for sustained and targeted delivery through nasal, pulmonary, vaginal and topical routes. Intranasal drug delivery system is a promising alternative route of administration for poor bioavailability drugs and it has advantages in term of increase patient acceptibility and...

Nasal Systematic Drug Delivery (Drugs and the Pharmaceutical Sciences)

Nasal Systematic Drug Delivery (Drugs and the Pharmaceutical Sciences)
by Yie Chien (Author)




Handbook of Non-Invasive Drug Delivery Systems: Science and Technology (Personal Care and Cosmetic Technology)

Handbook of Non-Invasive Drug Delivery Systems: Science and Technology (Personal Care and Cosmetic Technology)
by Vitthal S. Kulkarni PhD (Author)


With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological...

Leachables and Extractables Handbook: Safety Evaluation, Qualification, and Best Practices Applied to Inhalation Drug Products

Leachables and Extractables Handbook: Safety Evaluation, Qualification, and Best Practices Applied to Inhalation Drug Products
by Douglas J. Ball (Editor), Daniel L. Norwood (Editor), Cheryl L. M. Stults (Editor), Lee M. Nagao (Editor)


A practical and science-based approach for addressing toxicological concerns related to leachables and extractables associated with inhalation drug products Packaging and device components of Orally Inhaled and Nasal Drug Products (OINDP)—such as metered dose inhalers, dry powder inhalers, and nasal sprays—pose potential safety risks from leachables and extractables, chemicals that can be released or migrate from these components into the drug product. Addressing the concepts, background, historical use, and development of safety thresholds and their utility for qualifying leachables and extractables in OINDP, the Leachables and Extractables Handbook takes a practical approach to familiarize readers with the recent recommendations for safety and risk assessment established through a...

Nasal drug delivery system (Paperback) - Common

Nasal drug delivery system (Paperback) - Common
by By (author) Sonigara Bhawani Singh, By (author) Gupta Khem Chand By (author) Sarangdevot Kumkum (Author)


The novel carriers have been exploited through almost all the routes of administration. Many newer carriers are evolving with the advent of technology and the demand of targeted delivery like microemulsions. Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant. These systems are currently of interest because of their considerable potential to act as drug delivery vehic...

Nasal Drug Delivery: Development and Evaluation of Nasal Formulation by Basavaraj Nanjwade (2012-04-29)

Nasal Drug Delivery: Development and Evaluation of Nasal Formulation by Basavaraj Nanjwade (2012-04-29)
by Basavaraj Nanjwade;Kemy A. Parikh (Author)




Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists

Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists
by Thorsteinn Loftsson (Author)


Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences.  This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource.  Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more.  Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.Shows how...

Nasal and Pulmonary Drug Delivery System: Advancement in Naso-pulmonary Drug Delivery System

Nasal and Pulmonary Drug Delivery System: Advancement in Naso-pulmonary Drug Delivery System
by Rahul Satapara (Author), Vijay Satapara (Author), L.D. Patel (Author)


The widespread interest in intranasal route for therapeutic purposes other than the topically nasal drug delivery arises from the particular anatomical, physiological and histological characteristics of the nasal cavity, which provides potential for rapid systemic drug absorption and quick onset of action. In addition, intranasal absorption avoids the gastrointestinal and hepatic presystemic metabolism, enhancing drug bioavailability in comparison with that obtained after gastrointestinal absorption. Growing attention has been given to the potential of a pulmonary route as an non-invasive administration for systemic delivery of therapeutic agents (mainly peptides and proteins) due to the fact that the lungs could provide a large absorptive surface area (up to 100 m2 ) but extremely thin...

© 2016 BrightSurf.com