New therapeutic options for diabetes-related tissue injuryJuly 07, 2008Toronto, ON, Canada - Diabetes mellitus is a metabolic disorder characterized by altered glucose tolerance and impaired lipid and carbohydrate metabolism, and is associated with a number of complications directly resulting from hyperglycemiainduced inflammation. Vascular changes in diabetes lead to increased risk of myocardial infarction and stroke due to atherosclerosis, retinopathy, end-stage renal disease, debilitating neuropathies, poor wound healing, enhanced risk of infection, and periodontal disease. Studies of diabetic complications suggest that activation of the inflammatory response is mediated in large part by phagocytic cells, macrophages, and polymorphonuclear leukocytes. Both cell types assume an aggressive proinflammatory phenotype resulting from hyperglycemia. Today, during the 86th General Session of the International Association for Dental Research, investigators from Boston University report results from a study demonstrating that omega-6 and omega-3 fatty acids are precursors to a powerful new genus of anti-inflammatory and pro-resolution mediators, coined 'resolvins' and 'protectins'. These new local mediators counter-regulate pro-inflammatory signals and return tissues to homeostasis. These mediators reverse several of the proinflammatory functional responses of polymorphonuclear leukocytes and macrophages in vitro and prevent inflammation in a variety of animal models, and exhibit potential for new therapeutic options for resolving inflammation and tissue injury in diabetes. International & American Association for Dental Research |
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| Related Diabetes Current Events and Diabetes News Articles Flaxseed oil and osteoporosis Animal studies suggest that adding flaxseed oil to the diet could reduce the risk of osteoporosis in post-menopausal women and women with diabetes, according to a report to be published in the International Journal of Food Safety, Nutrition and Public Health. Diabetes surgery summit consensus lays foundation for new field of medicine A first-of-its-kind consensus statement on diabetes surgery is published online today in the Annals of Surgery. ESC to give talks on Diabetes in three cities in China As a result of successful events organised last year, a second Joint Scientific Forum, organised by the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD), two of the most respected professional medical organisations in Europe, will be held from 27-29 November at three venues across China - Beijing, Shanghai and Guangzhou. New research shows versatility of amniotic fluid stem cells For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought. First reconstitution of an epidermis from human embryonic stem cells Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM* Institute (I-STEM/ Inserm UEVE U861/AFM), published in the Lancet on 21 November 2009. The I-STEM team, directed by Marc Peschanski has just succeeded in recreating a whole epidermis from human embryonic stem cells. An atomic-level look at an HIV accomplice Since the discovery in 2007 that a component of human semen called SEVI boosts infectivity of the virus that causes AIDS, researchers have been trying to learn more about SEVI and how it works, in hopes of thwarting its infection-promoting activity. Scripps research scientists find new link between insulin and core body temperature A team led by scientists at The Scripps Research Institute have discovered a direct link between insulin-a hormone long associated with metabolism and metabolic disorders such as diabetes-and core body temperature. Scientists find molecular trigger that helps prevent aging and disease Researchers at Mount Sinai School of Medicine set out to address a question that has been challenging scientists for years: How do dietary restriction-and the reverse, overconsumption-produce protective effects against aging and disease? Pivotal study for PSD502 -- the first potential treatment for premature ejaculation At the annual meeting of the Sexual Medicine Society of North America (SMSNA), Inc. in San Diego, Sciele Pharma, Inc., a Shionogi Company and Plethora Solutions Limited, a wholly owned subsidiary of Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE)., today presented data from its second positive pivotal study of PSD502 for the treatment of premature ejaculation (PE). Night Beat, Overtime and a Disrupted Sleep Pattern Can Harm Officers' Health A police officer who works the night shift, typically from 8 p.m. to 4 a.m., already is at a disadvantage when it comes to getting a good "night's" sleep. More Diabetes Current Events and Diabetes News Articles |
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