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Neurogenesis in the adult brain: The association with stress and depression
July 09, 2008The brain is the key organ in the response to stress. Brain reactions determine what in the world is threatening and might be stressful for us, and regulate the stress responses that can be either adaptive or maladaptive. Chronic stress can affect the brain and lead into depression: Environmental stressors related to job or family situation are important triggers of depressive episodes and major life events such as trauma or abuse amongst the most potent factors inducing depression.
The World Health Organization (WHO) predicts that major depression will soon be the world's greatest public health burden. Thus optimising antidepressive therapy with regard to delayed or insufficient treatment response and unwanted side effects is urgent. Since the development of novel antidepressants is based upon an improved neurobiological understanding of this condition, new information about the cellular changes that take place in the brain is required.
Professor Fuchs from the Clinical Neurobiology Laboratory, German Primate Center in Goettingen, will present the latest findings on how brain cells can be adversely affected by stress and depression. He will explain how the adult brain is generating new cells and which impact these findings will have on the development of novel antidepressant drugs.
European College of Neuropsychopharmacology
European College of Neuropsychopharmacology
Depression Current Events and Depression News RSSAstrocytes and synaptic plasticity
By mopping up excess neurotrophic factor from neuronal synapses, astrocytes may finely tune synaptic transmission to affect processes such as learning and memory, say Bergami et al.
Has a new era of reinstitutionalization in mental health care begun?
A retrospective analysis of hospital episode statistics, involuntary admissions under the Mental Health Act 1983, and the number of psychiatric beds in England 1996-2006.
Compassion meditation may improve physical and emotional responses to psychological stress
Data from a new study suggests that individuals who engage in compassion meditation may benefit by reductions in inflammatory and behavioral responses to stress that have been linked to depression and a number of medical illnesses.
Millisecond brain signals predict response to fast-acting antidepressant
Images of the brain's fastest signals reveal an electromagnetic marker that predicts a patient's response to a fast-acting antidepressant, researchers have discovered.
Bullying of teenagers online is common, UCLA psychologists report
Nearly three in four teenagers say they were bullied online at least once during a recent 12-month period, and only one in 10 reported such cyber-bullying to parents or other adults, according to a new study by UCLA psychologists.
Getting help for depression and anxiety has significant long-term benefits
According to the Mood Disorder Society of Canada, about 1.3 million Canadians suffer from depression.
Smoking increases depression in women, study reveals
Researchers from the University of Melbourne and Barwon Health assessed a group of 1043 Australian women, whose health had been monitored for a decade as part of the Geelong Osteoporosis Study.
Learning to shape your brain activity
A study in the Oct. 1 issue of the journal Sleep shows that the successful manipulation of sensorimotor rhythm (SMR) amplitude by instrumental SMR conditioning (ISC) improved sleep quality as well as declarative learning. ISC might thus be considered a promising non-pharmacological treatment for primary insomnia.
Adolescent insomnia linked to depression and substance abuse during adolescence and young adulthood
A study in the Oct. 1 issue of the journal Sleep shows that adolescent insomnia symptoms are associated with depression, suicide ideation and attempts, and the use of alcohol, cannabis and other drugs such as cocaine.
MS patients have higher spinal fluid levels of suspicious immune molecule
A protein that helps keep immune cells quiet is more abundant in the spinal fluid of patients with multiple sclerosis (MS), further boosting suspicion that the protein, TREM-2, may be an important contributor to the disease.
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