 |
|
Genetic Engineering & Biotechnology News reports on novel hit-to-lead drug discovery
July 09, 2008Biotech and pharmaceutical firms are developing a host of new technologies designed to streamline the complicated drug discovery process, reports Genetic Engineering and Biotechnology News (GEN). Most successful approaches rely on a combination of high-throughput screening methods, miniaturization techniques, and advanced data-analysis tools, according to an article in the July issue (http://www.genengnews.com/articles/chitem.aspx?aid=2527) of GEN.
"The key goal for companies trying to develop new drugs is to find the best series of compounds that will optimize their chances of turning promising hits into even more promising leads," notes John Sterling, Editor in Chief of GEN.
Merck, for example, tries to make certain that its scientists work on physiologically relevant targets and assays during early-stage drug discovery research. For target identification the company uses RNAi technology in human cell lines. Multiparametric assays then generate biological activity profiles that can often provide valuable insight into complex disease models.
Pharmacopeia's screening platform is based on its ECLiPS® (encoded combinatorial libraries on polymeric support) technology. Three steps are involved in the firm's screening process. A primary high-throughput approach screens eluate from multiple beads. A follow-up protocol screens single bead eluates from those sublibraries, which demonstrate activity in the assay. Finally, company scientists submit beads for a decoding process, which is how they identify the structure of compounds in the active wells in step two.
Also discussed in the GEN article is drug discovery activities taking place at GlaxoSmithKline, Fujifilm, Archemix, and the Southern Research Institute.
Mary Ann Liebert, Inc./Genetic Engineering News
Pharmacopeia's screening platform is based on its ECLiPS® (encoded combinatorial libraries on polymeric support) technology. Three steps are involved in the firm's screening process. A primary high-throughput approach screens eluate from multiple beads. A follow-up protocol screens single bead eluates from those sublibraries, which demonstrate activity in the assay. Finally, company scientists submit beads for a decoding process, which is how they identify the structure of compounds in the active wells in step two.
Also discussed in the GEN article is drug discovery activities taking place at GlaxoSmithKline, Fujifilm, Archemix, and the Southern Research Institute.
Mary Ann Liebert, Inc./Genetic Engineering News
Drug Discovery Current Events and Drug Discovery News RSSUniversity of Minnesota invention will help speed development of drug treatments for heart failure
Research conducted by University of Minnesota scientists, in collaboration with Celladon Corporation, has led to the invention of technology to more rapidly identify compounds for the treatment of heart failure.
Diabetes surgery summit consensus lays foundation for new field of medicine
A first-of-its-kind consensus statement on diabetes surgery is published online today in the Annals of Surgery.
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
Researchers 'notch' a victory toward new kind of cancer drug
Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed.
New imagining technique could lead to better antibiotics and cancer drugs
A recently devised method of imaging the chemical communication and warfare between microorganisms could lead to new antibiotics, antifungal, antiviral and anti-cancer drugs, said a Texas AgriLife Research scientist.
Tiny injector to speed development of new, safer, cheaper drugs
It's no bigger than a stamp packet but it has the potential to allow rapid development of a new generation of drugs and genetic engineering organisms, and to better control in-vitro fertilization.
Pitt, US Army team designs new strategy to find drugs to treat neglected infection
Using an unconventional approach that they designed, University of Pittsburgh drug discoverers and their collaborators at Walter Reed Army Institute of Research have identified compounds that hold promise for treating leishmaniasis, a parasitic infection that many consider one of the world's most overlooked diseases.
Alzheimer's lesions found in the retina
The eyes may be the windows to the soul, but new research indicates they also may mirror a brain ravaged by Alzheimer's disease.
Scientists develop novel method to generate functional hepatocytes for drug testing
Scientists have for the first time produced liver cells from adult skin cells using the induced pluripotent stem cell (iPSC) technology.
Fate Therapeutics announces creation of small molecule platform for commercial-scale reprogramming
Fate Therapeutics, Inc. announced today the generation of human induced-pluripotent stem cells (iPSCs) using a combination of small molecules that significantly improves the speed and efficiency of reprogramming.
More Drug Discovery Current Events and Drug Discovery News Articles
 |
Real World Drug Discovery: A Chemist's Guide to Biotech and Pharmaceutical Research by Robert M. Rydzewski (Author) Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the... |
 |
Drugs: From Discovery to Approval by Rick Ng (Author) “Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs.” –Doody's Reviews, May 2009 "The second edition of a book that offers a user-friendly step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of preclinical trials." –Chemistry World, February 2009 The new edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the manufacturing processes... |
 |
Drug Discovery: A History by Walter Sneader (Author) Written by a leading authority with an excellent reputation and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures. This lively new text considers the origins, development and history of medicines that generate high media interest and have a huge social and economic impact on society. Set within a wide historical, social and cultural context, it provides expanded coverage of pre-twentieth century drugs, the huge advances made in the twentieth century and the latest developments in drug research. Hallmark features: Up-to-the-minute information in drug research Vignettes of special and unusual information, and anecdotes Discusses drug prototypes from all sources More... |
 |
Drug Discovery & Development - Advantage Business Media by Advantage Business Media A publication that provides the pharmaceutical and biotech research community with the latest drug discovery developments. |
 |
Textbook of Drug Design and Discovery, Third Edition by Povl Krogsgaard-Larsen (Editor), Tommy Liljefors (Editor), Ulf Madsen (Editor) Building on the success of the second edition, Textbook of Drug Design has been thoroughly revised and updated to provide a complete source of information on all facets of drug design for students of chemistry, pharmacy, pharmacology, biochemistry and medicine. The book follows drug design from the initial structure-activity relationship to the final processes of clinical evaluation and registration. Chapters investigate the design of drugs for particular cellular targets such as ion channels and receptors whilst others examine specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques and combinatorial approaches are also included. |
 |
Five Panel Integrated Cup Urine Test for Drugs (Case of 25 Tests) by Innovacon, Inc Case of 25 Tests Product Details EZ Drug Test Split Key Cup is 99% Accurate and gives results in minutes! Fully integrated cup where the tester does not have to come in contact with the urine. The Integrated cup has a new key feature. No more turning, simply put the key in and push. The collector retains control of the testing process and can time the results to insure proper interpretation. Separation of the sample from the remainder of sample sent for confirmation. No contamination of sample. New smaller size cup reduces shipping costs, decreases storage requirements. The cup has an easy Xerox feature where the cup can be laid down on its side and copied for retention of results with no leakage. New easy to open top for the confirmation lab. The cup is fully integrated where the... |
 |
2008 Global Conference: How to Keep New Drug Discoveries Coming Pharmaceutical firms have produced a string of blockbuster drugs that save lives and alleviate suffering. But lately their discovery model is striking out. Despite rising research and development budgets, fewer therapies are receiving FDA approval. Researchers are trying to tackle more complex diseases, but why haven't new tools improved productivity? How can new technologies pull risk forward, allowing failure to occur in the earlier clinical stages, when costs are lower? This session from the 2008 Milken Institute Global Conference takes a look at how to foster innovation that saves lives. This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply. |
 |
Two Panel Dip & Read Urine Test for Drugs by Discovery Drug Testing Features & Benefits FDA 510(K) cleared Up to 99% accurate lateral flow test Easy, one-step procedure Results stable for up to 4 hours Storage Room temperature Shelf life 24 months from date of manufacture No special storage requirements to maintain stability Small sample volume required, just dip Meets SAMHSA standards for substance abuse screening random, reasonable cause, corrections, clinical, hospital, and personal use. It is ideal for pre-employment, Read time 5 minutes |
 |
Operation One Shot Also With: Discovery Channel (Producer) |
 |
Explorations: Global Discoveries For Tomorrow's World (Drugs From The Sea/Oceanography in the Forest/El Nino on the Horizon) Also With: Ned Smith (Primary Contributor) |
| © 2009 BrightSurf.com |