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LSUHSC study finds high-dose HBO2 therapy extends survival window after cardiopulmonary arrest
July 16, 2008New Orleans, LA - A ground-breaking study by researchers at the School of Medicine at LSU Health Sciences Center New Orleans published in the August 2008 issue of Resuscitation has major implications for the #1 cause of death of Americans -- sudden cardiac arrest. The researchers stopped the heart of laboratory swine kept at room temperature, declared them dead from cardiac arrest, waited 25 minutes, and then resuscitated them with high doses of oxygen using hyperbaric oxygen therapy. The American Heart Association statistics on sudden death have shown that if a patient's heart is not restarted within 16 minutes with CPR, medications, and electric shocks, 100% of patients die.
"To resuscitate any living organism after 25 minutes of heart stoppage at room temperature has never been reported and suggests that the time to successful resuscitation in humans may be extended beyond the stubborn figure of 16 minutes that has stood for 50 years," notes Dr. Keith Van Meter, Clinical Professor of Medicine and Chief of the Section of Emergency Medicine at LSU Health Sciences Center New Orleans, who led the study.
The study involved the use of three groups of laboratory swine. All swine underwent cardiac arrest for 25 minutes during which time they received no artificial breathing, CPR, medications, or electric shocks. After 25 minutes the swine were randomly divided into 3 groups. The first group remained at normal pressure. The second group was given standard-dose hyperbaric oxygen, and the third group was given high-dose hyperbaric oxygen, a dose that is nearly 1/3 more than the highest dose currently given to humans. Advanced cardiac life support (ACLS) was started on animals in all groups for a two-hour resuscitation period. After the two-hour resuscitation period, four of the six animals in the high-dose hyperbaric oxygen group could be resuscitated. None of the subjects in the other groups were able to be resuscitated.
"The present study shows that short-term high-dose hyperbaric oxygen is an effective resuscitation tool and is safe in a small multiplace hyperbaric chamber," concludes Dr. Van Meter. "A rehearsed team can easily load a patient in cardiopulmonary arrest into a small multiplace chamber in the pre-hospital or hospital setting without interrupting CPR or advanced cardiac life support. Successful resuscitation at 25 minutes suggests that if high dose hyperbaric oxygen is used at the current ACLS limit of 16 minutes, a greater survival may be achieved in humans and allow application of more definitive treatment such as clot dissolving drugs."
The research team also included LSU Health Sciences Center New Orleans faculty Diana Barratt, MD, MPH, Heather Murphy-Lavoie, MD, Paul G. Harch, MD, James Moises, MD, and Nicolas Bazan, MD, PhD. and
Future studies are planned to further refine knowledge about this important addition to resuscitation and survival procedures.
Louisiana State University Health Science Center
"The present study shows that short-term high-dose hyperbaric oxygen is an effective resuscitation tool and is safe in a small multiplace hyperbaric chamber," concludes Dr. Van Meter. "A rehearsed team can easily load a patient in cardiopulmonary arrest into a small multiplace chamber in the pre-hospital or hospital setting without interrupting CPR or advanced cardiac life support. Successful resuscitation at 25 minutes suggests that if high dose hyperbaric oxygen is used at the current ACLS limit of 16 minutes, a greater survival may be achieved in humans and allow application of more definitive treatment such as clot dissolving drugs."
The research team also included LSU Health Sciences Center New Orleans faculty Diana Barratt, MD, MPH, Heather Murphy-Lavoie, MD, Paul G. Harch, MD, James Moises, MD, and Nicolas Bazan, MD, PhD. and
Future studies are planned to further refine knowledge about this important addition to resuscitation and survival procedures.
Louisiana State University Health Science Center
Resuscitation Current Events and Resuscitation News RSSEffect of real-time CPR feedback reported at resuscitation science symposium
Emergency medical service (EMS) providers in the United States assess an estimated 350,000 cardiac arrests each year. Only 5 to 10 percent of people who have sudden cardiac arrest survive. Better quality cardiopulmonary resuscitation (CPR) provided by prehospital EMS providers may be associated with better patient outcome.
Continuous chest compression-CPR improved cardiac arrest survival in Arizona
The chance of surviving a cardiac arrest outside a hospital was found to be twice as high when bystanders performed continuous chest compressions without mouth-to-mouth breathing than when bystanders performed standard CPR.
Less than 1 in 3 Toronto bystanders who witness a cardiac arrest try to help: Study
Researchers at St. Michael's Hospital working in conjunction with EMS services, paramedics and fire services across Ontario found that a bystander who attempts cardiopulmonary resuscitation (CPR) can quadruple the survival rate to over 50 per cent.
NHLBI stops enrollment in study on resuscitation methods for cardiac arrest
Enrollment has ended early in a large, multicenter clinical trial comparing two distinct resuscitation strategies delivered by emergency medical service (EMS) providers to increase blood flow during cardiac arrest.
Study dispels myth that new residents cause increase in medical errors in July
New research published in the September issue of the Journal of the American College of Surgeons challenges the widely held belief that more medical errors occur in teaching hospitals during the month of July due to the influx of new graduates from medical and nursing schools - also known as the "July Phenomenon."
Pre-hospital organization: The first links in the chain of survival for heart attack patients
Mortality rate following a heart attack has fallen by more than 50% in Europe over the past 25 years. However, because only minor advances in the medical treatment of AMI are expected over the next decade, it is through organisational changes in the pre-hospital phase that mortality rate will continue this decline to below 5%.
New strategies for reperfusion therapy
A new trial has begun in order to ascertain once and for all whether the best strategy for patients who cannot receive P-PCI is early fibrinolysis, together with mandated angiography.
Cardiac arrest casualties form a valuable source of donor kidneys
A pilot study of a system for harvesting kidneys from non-heart-beating donors where attempts of resuscitation after a witnessed out-of-hospital cardiac arrest have failed (uncontrolled NHBDs) resulted in 21 successful kidney transplants - a 10% increase in the transplantation rate - over 17 months.
Cardiac arrest resuscitation: Passive oxygen flow better than assisted ventilation
Arizona researchers have added another piece to the mounting body of evidence that suggests during resuscitation efforts to treat patients in cardiac arrest, "passive ventilation" significantly increases survival rates, compared to the widely practiced "assisted ventilation."
Scientific community urges officials and public to use latest evidence as guide in H1N1 prevention and protection procedures
As flu season draws nearer along with the potential for resurgence in H1N1, leading infectious diseases doctors, hospital epidemiologists, and infection preventionists urge officials to base recommendations for the public and healthcare workers on scientific knowledge and frontline experience gained from the outbreak this summer.
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Cardiac Arrest: The Science and Practice of Resuscitation Medicine, 2nd Edition by Norman A. Paradis (Editor), Henry R. Halperin (Editor), Karl B. Kern (Editor), Volker Wenzel (Editor), Douglas A. Chamberlain (Editor) Cardiac Arrest is the definitive and most comprehensive reference volume in advanced life support and resuscitation medicine. This new edition brings the reader completely up-to-date with developments in the field, focusing on practical issues of decision making, clinical management and prevention, as well as providing explanations of the science informing the practice. This volume is essential reading for all those involved in the emergency care of cardiac patients, either in the pre-hospital or hospital setting. |
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Resuscitation by Adult. |
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Critical Care & Resuscitation by Joint Fac Intensive Care Med Serves the needs of medical practitioners in Australia and New Zealand. Established for the advancement of clinical education and research in Australasian Critical Care and Intensive Care Medicine. | |
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Neonatal Resuscitation Textbook (Neonatal Resuscitation: Textbook) by John, M.D. Kattwinkel (Editor) The new fifth edition provides students with a complete self-study program, including case scenarios for each major resuscitation technique; Medication Performance Checklist; required megacode; review modules, and more. Also, included with the text is the new interactive DVD, which includes video of actual resuscitations, laryngoscopic camera footage, interactive scenarios, plus 3-D demonstrations and other visuals not found in the book. |
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AMBU RES CUE RESUSCITATION MASK by AMBU INC The newest pocket size CPR mouth barrier has a transparent dome and completely seals to the faces of infants, children and adults. Replaceable one-way valve. Includes gloves and alcohol wipes in a hard plastic case. |
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Family & Friends CPR Anytime Personal Learning Program by Laerdal Kit for personal use with family and friends. Latex Free. Directions printed inside the box. |
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CPR - The Way To Save Lives (Cardiopulmonary Resuscitation For The General Public) Also With: Dan Halligan (Producer) Following the basic life support standards of the American Heart Association and the American Red Cross, gives easy-to-understand instruction in adult, child and infant CPR. |
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DAN Oronasal Resuscitation Mask by DAN Free DAN Protective Case included For use in providing mouth to mask ventilations (rescue breathing) to a non-breathing person Equipped with an oxygen inlet port Effective barrier to protect the rescuer from direct contact with the non-breathing person's face Reduces the risk of possible disease transmission Reusable and easy to clean FULL MANUFACTURER'S WARRANTY *SCUBA diving equipment |
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Mouth To Mouth Resuscitation Party Decoration Necktie by SHOPZEUS Party decoration necktie with sublimated artwork. High quality, silky touch, snow white polyester. Ideal birthday gift. Sublimation and shipping might take 6-10 business days. |
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Experiments In The Revival Of Organisms Film DVD: 1940 Film "Experiments In The Revival Of Organisms" About Resuscitation & The History Of The Revival Of Animals, From Russia This film documents some early Russian scientific experiments with the resuscitation of animals. Dr. S.S. Bryukhonenko at the Institute of Experimental Physiology and Therapy, Voronezh, U.S.S.R. The footage is bizarre to say the least. Table Of Contents: (1) Experiment in the Revival of Organisms (1940) - This film documents some early Russian scientific experiments with the resuscitation of animals, mostly dogs, by Dr. S.S. Bryukhonenko at the Institute of Experimental Physiology and Therapy, Voronezh, U.S.S.R. - 20 Minutes |
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