 |
|
LSUHSC study finds high-dose HBO2 therapy extends survival window after cardiopulmonary arrest
July 16, 2008New Orleans, LA - A ground-breaking study by researchers at the School of Medicine at LSU Health Sciences Center New Orleans published in the August 2008 issue of Resuscitation has major implications for the #1 cause of death of Americans -- sudden cardiac arrest. The researchers stopped the heart of laboratory swine kept at room temperature, declared them dead from cardiac arrest, waited 25 minutes, and then resuscitated them with high doses of oxygen using hyperbaric oxygen therapy. The American Heart Association statistics on sudden death have shown that if a patient's heart is not restarted within 16 minutes with CPR, medications, and electric shocks, 100% of patients die.
"To resuscitate any living organism after 25 minutes of heart stoppage at room temperature has never been reported and suggests that the time to successful resuscitation in humans may be extended beyond the stubborn figure of 16 minutes that has stood for 50 years," notes Dr. Keith Van Meter, Clinical Professor of Medicine and Chief of the Section of Emergency Medicine at LSU Health Sciences Center New Orleans, who led the study.
The study involved the use of three groups of laboratory swine. All swine underwent cardiac arrest for 25 minutes during which time they received no artificial breathing, CPR, medications, or electric shocks. After 25 minutes the swine were randomly divided into 3 groups. The first group remained at normal pressure. The second group was given standard-dose hyperbaric oxygen, and the third group was given high-dose hyperbaric oxygen, a dose that is nearly 1/3 more than the highest dose currently given to humans. Advanced cardiac life support (ACLS) was started on animals in all groups for a two-hour resuscitation period. After the two-hour resuscitation period, four of the six animals in the high-dose hyperbaric oxygen group could be resuscitated. None of the subjects in the other groups were able to be resuscitated.
"The present study shows that short-term high-dose hyperbaric oxygen is an effective resuscitation tool and is safe in a small multiplace hyperbaric chamber," concludes Dr. Van Meter. "A rehearsed team can easily load a patient in cardiopulmonary arrest into a small multiplace chamber in the pre-hospital or hospital setting without interrupting CPR or advanced cardiac life support. Successful resuscitation at 25 minutes suggests that if high dose hyperbaric oxygen is used at the current ACLS limit of 16 minutes, a greater survival may be achieved in humans and allow application of more definitive treatment such as clot dissolving drugs."
The research team also included LSU Health Sciences Center New Orleans faculty Diana Barratt, MD, MPH, Heather Murphy-Lavoie, MD, Paul G. Harch, MD, James Moises, MD, and Nicolas Bazan, MD, PhD. and
Future studies are planned to further refine knowledge about this important addition to resuscitation and survival procedures.
Louisiana State University Health Science Center
"The present study shows that short-term high-dose hyperbaric oxygen is an effective resuscitation tool and is safe in a small multiplace hyperbaric chamber," concludes Dr. Van Meter. "A rehearsed team can easily load a patient in cardiopulmonary arrest into a small multiplace chamber in the pre-hospital or hospital setting without interrupting CPR or advanced cardiac life support. Successful resuscitation at 25 minutes suggests that if high dose hyperbaric oxygen is used at the current ACLS limit of 16 minutes, a greater survival may be achieved in humans and allow application of more definitive treatment such as clot dissolving drugs."
The research team also included LSU Health Sciences Center New Orleans faculty Diana Barratt, MD, MPH, Heather Murphy-Lavoie, MD, Paul G. Harch, MD, James Moises, MD, and Nicolas Bazan, MD, PhD. and
Future studies are planned to further refine knowledge about this important addition to resuscitation and survival procedures.
Louisiana State University Health Science Center
Resuscitation Current Events and Resuscitation News RSSSleep Apnea May Be Risk Factor for Sudden Cardiac Death, Mayo Clinic Research Concludes
After studying the sleep characteristics of nearly 11,000 adults in an overnight sleep laboratory, Mayo Clinic researchers suggest that obstructive sleep apnea (OSA) - and, in particular, the low nighttime oxygen saturation of the blood it causes - may be a risk factor for sudden cardiac death (SCD).
Mayo Clinic study finds risk of sudden cardiac death highest early after attack
People who survive a heart attack face the greatest risk of dying from sudden cardiac death (SCD) during the first month after leaving the hospital, according to a long-term community study by Mayo Clinic researchers of nearly 3,000 heart attack survivors.
Study findings help EMS respond to cardiac arrest emergencies more safely and efficiently
When cardiac arrest patients cannot successfully be resuscitated by emergency medical services in the field, lifesaving attempts to race them to a nearby hospital via ambulance often prove to be futile.
Strategies for preventing gastrointestinal complications in severely burned patients
Gastrointestinal dysfunction is a common complication of severe burns. Injury to GI function, especially to GI barrier function, is an important initiator as well as a stimulator for occurrence of systemic inflammatory response syndrome, sepsis and multiple organ dysfunction syndrome following severe burns.
Hopkins Children's study: Parents of dying newborns need clearer explanation of options
Parent-doctor discussions about whether to maintain or withdraw life support from terminally ill or severely premature newborns are so plagued by miscommunication and misunderstanding that they might as well be in different languages.
Smoking during pregnancy a 'double-edged sword' in SIDS
Premature infants whose mothers smoked during pregnancy may be at even higher risk for sudden infant death syndrome (SIDS) than preemies whose mothers did not smoke, according to new research out of the University of Calgary.
Orange County research program aims to improve severe trauma survival rates
A method of resuscitation for victims of severe traumatic injury will be the subject of a clinical trial to be undertaken by a team of Orange County emergency care providers.
Resuscitation technique after brain injury may do more harm than good
The current standard practice of giving infants and children 100 percent oxygen to prevent brain damage caused by oxygen deprivation may actually inflict additional harm, researchers at UT Southwestern Medical Center have found.
Hyperviscous fluids: Better treatment for severe blood loss
Intravenous administration of isotonic fluids is the standard emergency treatment in the U.S. for patients with severe blood loss, but UC San Diego bioengineering researchers have reported improved resuscitation with a radically different approach.
Automated External Defibrillators and CPR Are Equally Helpful for Sudden Cardiac Arrest in the Home
The first study to explore the use of automated external defibrillator (AEDs) in the home has found that although the safe and easy-to-use devices are effective for certain types of cardiac arrest, they were underused.
More Resuscitation Current Events and Resuscitation News Articles
 | Textbook of Neonatal Resuscitation (Neonatal Resuscitation: Textbook) The new fifth edition provides students with a complete self-study program, including case scenarios for each major resuscitation technique; Medication Performance Checklist; required megacode; review modules, and more. Also, included with the text is the new interactive DVD, which includes video of actual resuscitations, laryngoscopic camera footage, interactive scenarios, plus 3-D... |
| Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care 2005 by American Heart Association | |
 | Resuscitation Technology by Gordon E. Bradshaw |
 | Trauma Nursing: From Resuscitation Through Rehabilitation by Karen A. McQuillan, Mary Beth Flynn Makic, Eileen Whalen Using the unique cycles of trauma framework, the 4th edition of this classic and highly acclaimed resource is thoroughly updated to bring you comprehensive coverage of cutting-edge research findings and current issues, trends, and controversies in trauma nursing. Detailed information guides you through all phases of care - from preventive care and the time of injury to the resuscitative,... |
 | The S.T.A.B.LE. Program: Pre-transport / Post-resuscitation Stabilization Care Of Sick Infants: Guidelines For Neonatal Healthcare Providers; Learner Manual ... / Post-Resuscition Stabilization) by Kristine A. Karlsen The S.T.A.B.L.E. Program is a neonatal education program that focuses on the post-resuscitation/pre-transport stabilization care of sick newborns. S.T.A.B.L.E. stands for the 6 assessment parameters covered in the program: Sugar, Temperature, Airway, Blood pressure, Lab work, and Emotional support for the family. The S.T.A.B.L.E. Program is designed to provide important information about neonatal... |
 | Palliative Care Resuscitation by Madeline Bass This book provides an up to date reference for healthcare professionals working in palliative care. It provides an overview of resuscitation in palliative care, and then looks at guidelines, decision making, including patient and family in the decision making process and the law and ethics of resuscitation. Written in an easily understandable and absorbable manner, it brings to light the... |
 | Resuscitation of a Hanged Man by Denis Johnson Leonard English, a sad and intense young man recovering from a suicide attempt, moves to the Cape Cod resort of Provincetown to work as a disk jockey cum private detective. On his first day there, he encounters a beautiful young woman and falls desperately in love with her -- only to find out she prefers those of her own sex to men. English's first assignment, a search for an elusive artist,... |
 | Cardiac Arrest: The Science and Practice of Resuscitation Medicine, 2nd Edition Cardiac Arrest is the definitive and most comprehensive reference volume in advanced life support and resuscitation medicine. This new edition brings the reader completely up-to-date with developments in the field, focusing on practical issues of decision making, clinical management and prevention, as well as providing explanations of the science informing the practice. This volume is essential... |
 | Trauma: Emergency Resuscitation, Perioperative Anesthesia, Surgical Management, Volume I Produced by a world renowned team of trauma specialists, this source reviews initial management considerations beginning in the pre-hospital phase, continues through the primary and secondary surveys of the hospital-based evaluation process, and proceeds to the perioperative management of trauma, burns, and associated conditions. This reference provides practical and expertly written chapters... |
| Trauma Nursing: From Resuscitation Through Rehabilitation by Virginia D., Rn. Cardona, Patricia D., Phd Hurn Maryland Institute for Emergency Medical Services Systems, Baltimore. New edition of a comprehensive text for emergency nurses. Four sections cover general concepts, clinical management concepts, single system injuries, and unique patient populations. Illustrated. 46 U.S.... |
| © 2009 BrightSurf.com |