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Kidney damage caused by iodinated contrast material thought to be overestimated, study shows
July 17, 2008The use of iodinated contrast material may be less damaging to the kidneys than previously recorded, according to a recent study conducted by researchers at Columbia University Medical Center in New York, NY.
"We reviewed patient records to determine the frequency and magnitude of serum creatinine changes in patients who had not received iodinated contrast material. We then compared that to previously published articles which found a relationship between contrast media, serum creatinine levels and nephropathy (kidney damage). "We found that the creatinine level increases just as often in those who do not receive contrast material as in those who do," said Jeffrey Newhouse, MD, lead author of the study.
According to the study, among the 32,161 patients who had not received contrast material, more than half showed a change of at least 25%, and more than 2/5 showed a change of at least 0.4 milligrams per deciliter. "These changes occurred in patients with both normal and abnormal initial creatinine values and were undoubtedly caused by the entire range of conditions, treatments, and laboratory variations that may alter creatinine levels," said Dr. Newhouse. "These changes were not different from those seen in previously published studies in which the patients received contrast media."
"Because serum creatinine levels change frequently in the absence of iodinated contrast media material, prior studies of the relationship between iodinated contrast material and renal function must be interpreted with caution, and future experiments should have appropriate controls," Dr. Newhouse said. "We don't claim that IV contrast material never induces nephropathy, but it may do so less frequently and severely than previously thought. If subsequent experimentation proves its safety, it could be used more frequently in patients with renal failure," he said.
American Roentgen Ray Society
"Because serum creatinine levels change frequently in the absence of iodinated contrast media material, prior studies of the relationship between iodinated contrast material and renal function must be interpreted with caution, and future experiments should have appropriate controls," Dr. Newhouse said. "We don't claim that IV contrast material never induces nephropathy, but it may do so less frequently and severely than previously thought. If subsequent experimentation proves its safety, it could be used more frequently in patients with renal failure," he said.
American Roentgen Ray Society
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Allergic-like reactions to iodinated contrast material treated safely with commonly used medications
Patients who have had acute allergic-like reactions to nonionic iodinated contrast material rarely develop any serious long-term problems and can be treated safely with commonly used medications according to a recent study conducted by researchers at the University of Michigan Hospitals in Ann Arbor.
MRI better than MDCT in detecting endoleaks, study says
Contrast-enhanced MR imaging is significantly superior to 16 slice multidetector CT in the detection of endoleaks after endovascular repair of abdominal aortic aneurisms (EVAR), according to a recent study conducted by researchers at Ospedale San Giovanni in Bellinzona, Switzerland.
Allergic-like reactions occur in premedicated patients
Allergic-like reactions can occur in patients (both children and adults) when given gadolinium containing contrast agents, even if they have been pre-medicated with corticosteroids and antihistamines, according to a recent study conducted by researchers at the University of Michigan Health Systems in Ann Arbor.
Newer contrast agents safe for children
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Contrast Media: Safety Issues and ESUR Guidelines (Medical Radiology / Diagnostic Imaging) by Henrik S. Thomsen (Editor), Judith A.W. Webb (Editor) This second, revised edition of Contrast Media: Safety Issues and Guidelines, presented in a handy, easy to use format, provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media. It not only updates the successful first edition, but also contains a number of completely new chapters, for example on gadolinium-based contrast agents, meta-analyses in contrast media research and various regulatory issues. Comprehensive consideration is given to the many different safety issues relating to iodinated, MR, ultrasound and barium contrast media. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All those questions frequently raised in radiological practice are... |
![Monitoring of iodinated X-ray contrast media in surface water [An article from: Chemosphere]](http://ecx.images-amazon.com/images/I/51M6G4MFGFL._SL160_.jpg) |
Monitoring of iodinated X-ray contrast media in surface water [An article from: Chemosphere] by W. Seitz (Author), W.H. Weber (Author), J.Q. Jiang (Author), B.J. Lloyd (Author), Maie (Author) This digital document is a journal article from Chemosphere, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: A monitoring programme was carried out in order to determine iodinated X-ray contrast media (ICM) in the River Danube and to investigate the raw water quality for drinking water production at Langenau waterworks. The study revealed that the maximum concentrations of ICM (over 500ngl^-^1 for diatrizoic acid and iopamidol) were found in 2h-composite samples taken from the downstream of the Ulm/Neu-Ulm metropolitan area. By means of a concentration profile over one month the highest ICM concentrations were observed on... |
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Thromboembolic Risks in Angiography:: Role of Iodinated Contrast Media by Rosy Eloy (Editor) | |
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Biodegradability of the X-ray contrast compound diatrizoic acid, identification of aerobic degradation products and effects against sewage sludge micro-organisms [An article from: Chemosphere] by A. Haisz (Author), K. Kummerer (Author) This digital document is a journal article from Chemosphere, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Pharmaceuticals and contrast media have been detected in hospital effluents, sewage treatment plants, surface water, and ground water. Only little is known about their elimination during sewage treatment and effects of possible biotransformation products against bacteria. The modified Zahn-Wellens test (ZWT, OECD 302 B) and a test simulating biological sewage treatment (modified OECD 303 A test) were used to assess the biodegradability of the widely used ionic iodinated contrast agent diatrizoic acid (diatrizoate). Effects... |
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