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First worldwide analysis of cancer survival finds wide variation between countries
July 17, 2008Black men and women have substantially lower survival than white men and women in the United States, but US has the highest survival for prostate cancer of all 31 countries included
Cancer survival varies widely between countries according to a worldwide study published online today in Lancet Oncology.* More than 100 investigators contributed to the study.
And while the USA has the highest 5-year survival rate for prostate cancer than any of the 31 countries studied, cancer survival in black men and women is systematically and substantially lower than in white men and women.
Until now, direct comparisons of cancer patient survival between rich and poor countries have not generally been available. The CONCORD study is, to the authors' knowledge, the first worldwide analysis of cancer survival, with standard quality-control procedures and identical analytic methods for all datasets. It provides directly comparable data on 1.9 million adult cancer patients (aged between 15 and 99) from 101 cancer registries in 31 countries on 5 continents. The study covers cancers of the breast (women), colon, rectum and prostate, which comprise a majority of all newly diagnosed cancers in adults. The study includes analyses of cancer survival in 16 states and 6 metropolitan areas in the USA, covering 42% of the population - four times as many as in previous studies.
Five-year relative survival for breast cancer (women) ranged from 80% or higher in North America, Sweden, Japan, Finland and Australia to less than 60% in Brazil and Slovakia, and below 40% in Algeria. Survival for white women in the USA (84.7%) was 14% higher than for black women (70.9%).
For colorectal cancer, five-year survival was higher in North America, Japan, Australia and some western European countries and lower in Algeria, Brazil and in eastern European countries. Survival for white patients in the USA was 10% higher than for black patients (60% compared with 50%).
For prostate cancer, 5-year survival was higher in the USA (92%) than in all 30 of the other participating countries. However, there was a 7% difference in survival between black and white men (92% compared with 85.8%).
Michel P Coleman, Professor of Epidemiology and Vital Statistics at the London School of Hygiene & Tropical Medicine, and lead author of the study, comments: 'The differences in cancer survival between countries and between black and white men and women in the USA are large and consistent across geographic areas. Most of the wide variation in survival is likely to be due to differences in access to diagnostic and treatment services, and factors such as tumour biology, state at diagnosis or compliance with treatment may also be significant.
'Population-based cancer registries are increasingly important in monitoring cancer control efforts, and in evaluating cancer survival. We hope that the information provided here will facilitate better comparison between rich and poor countries, and eventually enable joint evaluation of international trends in cancer incidence, survival and mortality'.
London School of Hygiene & Tropical Medicine
Until now, direct comparisons of cancer patient survival between rich and poor countries have not generally been available. The CONCORD study is, to the authors' knowledge, the first worldwide analysis of cancer survival, with standard quality-control procedures and identical analytic methods for all datasets. It provides directly comparable data on 1.9 million adult cancer patients (aged between 15 and 99) from 101 cancer registries in 31 countries on 5 continents. The study covers cancers of the breast (women), colon, rectum and prostate, which comprise a majority of all newly diagnosed cancers in adults. The study includes analyses of cancer survival in 16 states and 6 metropolitan areas in the USA, covering 42% of the population - four times as many as in previous studies.
Five-year relative survival for breast cancer (women) ranged from 80% or higher in North America, Sweden, Japan, Finland and Australia to less than 60% in Brazil and Slovakia, and below 40% in Algeria. Survival for white women in the USA (84.7%) was 14% higher than for black women (70.9%).
For colorectal cancer, five-year survival was higher in North America, Japan, Australia and some western European countries and lower in Algeria, Brazil and in eastern European countries. Survival for white patients in the USA was 10% higher than for black patients (60% compared with 50%).
For prostate cancer, 5-year survival was higher in the USA (92%) than in all 30 of the other participating countries. However, there was a 7% difference in survival between black and white men (92% compared with 85.8%).
Michel P Coleman, Professor of Epidemiology and Vital Statistics at the London School of Hygiene & Tropical Medicine, and lead author of the study, comments: 'The differences in cancer survival between countries and between black and white men and women in the USA are large and consistent across geographic areas. Most of the wide variation in survival is likely to be due to differences in access to diagnostic and treatment services, and factors such as tumour biology, state at diagnosis or compliance with treatment may also be significant.
'Population-based cancer registries are increasingly important in monitoring cancer control efforts, and in evaluating cancer survival. We hope that the information provided here will facilitate better comparison between rich and poor countries, and eventually enable joint evaluation of international trends in cancer incidence, survival and mortality'.
London School of Hygiene & Tropical Medicine
Cancer Survival Current Events and Cancer Survival News RSSOther Illnesses, Body Weight Do Not Explain Racial Disparities in Colon Cancer Survival, UAB Researchers Say
A new study by University of Alabama at Birmingham (UAB) researchers shows that body-mass index (BMI) and co-existing medical conditions (co-morbidity) do not explain the decreased survival observed among African-Americans compared to Caucasians who also have colon cancer.
African-Americans with colorectal cancer have poorer outcomes, lower survival rates
New research published in the November issue of the Journal of the American College of Surgeons shows that African-American patients with colorectal cancer are more likely to be diagnosed with advanced disease and are less likely to undergo surgical procedures compared with Caucasians, suggesting that improvements in screening and rates of operation may reduce differences in colorectal cancer outcomes for African-Americans.
Small peptide found to stop lung cancer tumor growth in mice
In new animal research done by investigators at Wake Forest University School of Medicine, scientists have discovered a treatment effective in mice at blocking the growth and shrinking the size of lung cancer tumors, one of the leading causes of cancer death in the world.
Long-term tamoxifen use increases risk of an aggressive, hard to treat type of second breast cancer
While long-term tamoxifen use among breast cancer survivors decreases their risk of developing the most common, less aggressive type of second breast cancer, such use is associated with a more than four-fold increased risk of a more aggressive, difficult-to-treat type of cancer in the breast opposite, or contralateral, to the initial tumor.
Cost-effective strategy to screen second primary colorectal cancers in cancer survivors
To suggest a feasible economic strategy for second primary colorectal cancer screening of cancer survivors in Korea, A research group constructed a decision-analytic model, compared cost-effectiveness results of cancer screening in male cancer survivors.
Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
A new finding reveals that African-American patients with breast, ovarian, and prostate cancer tend to die earlier than patients of other races with these cancers, even when they receive identical medical treatment and when socioeconomic factors are controlled for.
2 reproductive factors are important predictors of death from ovarian cancer
Researchers from the Centers for Disease Control and Prevention (CDC) found that survival among women with ovarian cancer is influenced by age of menarche and total number of lifetime ovulatory cycles.
Researchers identify biological markers that may indicate poor breast cancer prognosis
A team of researchers has found an association between breast cancer survival and two proteins that, when present in the blood in high levels, are indicators of inflammation.
Exercise programs may improve symptoms in non-small cell lung cancer patients
Exercise is known to have a positive effect on maintaining a healthy lifestyle, and a study in the May issue of the Journal of Thoracic Oncology has shown that exercise also plays an important role in both primary and secondary prevention of cancer.
Study of neighborhoods points to modifiable factors, not race, in cancer disparities
While cities have shown considerable racial disparities in cancer survival, those racial disparities virtually disappear among smaller populations, such as neighborhoods within that city.
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