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Want a reason to love your lower belly fat? It's rich in stem cells
July 24, 2008ASPS study finds some areas of the body have greater concentrations of stem cells
ARLINGTON HEIGHTS, Ill. - Fat removed from the lower abdomen and inner thigh through liposuction was found to be an excellent source of stem cells, with higher stem cell concentrations than other areas of the body, reports a Brazilian-based study in August's Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). This is the first study of its kind to examine whether fat tissues from different areas of the body vary in stem cell concentration.
"Adult stem cells, derived from our own tissues, hold strong promise for improved clinical therapies," said J. Peter Rubin, MD, a member of the ASPS Fat Grafting Task Force who is involved in pre-clinical trial work on stem cells taken from fat. "The potential for healing and repairing injury or disease through stem cells, including conditions like breast cancer and reconstruction, heart failure, spinal injuries, diabetes and Parkinson's disease are incredible. We may be able to more permanently and naturally get rid of pesky wrinkles or augment breasts with stem cell enriched fat in the future as well. Knowing more about the biology of stem cells will be of great value when we are ready for clinical trials in this country."
In the study, 23 female patients having liposuction in at least four different body areas agreed to have their fat isolated for adult stem cells and analyzed to determine stem cell concentrations. The body areas that were liposuctioned were: lower abdomen, upper abdomen, inner knee, inner thigh, flank and hips.
The study results found a significant difference in stem cell concentrations in different areas of the body. A major finding was that the concentration of stem cells was greatest in the lower abdomen and inner thighs. Interestingly, stem cell concentration in the lower abdomen was five times greater than in the upper abdomen.
"The value of stem cells harvested through fat is the ready and ample supply available," said ASPS President Richard D'Amico, MD. "Using stem cells will some day have very practical applications to the specialty of plastic surgery. That we may be able to generate new tissue or bone that can be used in many of the reconstructive and cosmetic procedures we do every day is a tremendous."
Stem cells are unspecialized cells that have not yet developed a specific function. Not only are they capable of self renewal, stem cells can divide and produce others that become specialized cells. Scientists and doctors theorize that stem cells will be able to repair or replace damaged or diseased cells. Clinical trials researching the potential of stem cells from fat are ongoing in Europe and Asia. In the U.S., there are many investigators doing pre-clinical trial work to meet the stringent safety guidelines the FDA sets for clinical trials.
According to ASPS statistics, more than 301,000 liposuction procedures were performed in 2007.
American Society of Plastic Surgeons
In the study, 23 female patients having liposuction in at least four different body areas agreed to have their fat isolated for adult stem cells and analyzed to determine stem cell concentrations. The body areas that were liposuctioned were: lower abdomen, upper abdomen, inner knee, inner thigh, flank and hips.
The study results found a significant difference in stem cell concentrations in different areas of the body. A major finding was that the concentration of stem cells was greatest in the lower abdomen and inner thighs. Interestingly, stem cell concentration in the lower abdomen was five times greater than in the upper abdomen.
"The value of stem cells harvested through fat is the ready and ample supply available," said ASPS President Richard D'Amico, MD. "Using stem cells will some day have very practical applications to the specialty of plastic surgery. That we may be able to generate new tissue or bone that can be used in many of the reconstructive and cosmetic procedures we do every day is a tremendous."
Stem cells are unspecialized cells that have not yet developed a specific function. Not only are they capable of self renewal, stem cells can divide and produce others that become specialized cells. Scientists and doctors theorize that stem cells will be able to repair or replace damaged or diseased cells. Clinical trials researching the potential of stem cells from fat are ongoing in Europe and Asia. In the U.S., there are many investigators doing pre-clinical trial work to meet the stringent safety guidelines the FDA sets for clinical trials.
According to ASPS statistics, more than 301,000 liposuction procedures were performed in 2007.
American Society of Plastic Surgeons
Stem Cells Current Events and Stem Cells News RSSFirst reconstitution of an epidermis from human embryonic stem cells
Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM* Institute (I-STEM/ Inserm UEVE U861/AFM), published in the Lancet on 21 November 2009. The I-STEM team, directed by Marc Peschanski has just succeeded in recreating a whole epidermis from human embryonic stem cells.
Bone Implant Offers Hope for Skull Deformities
A synthetic bone matrix offers hope for babies born with craniosynostosis, a condition that causes the plates in the skull to fuse too soon.
Your Own Stem Cells Can Treat Heart Disease
The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn't receive stem cells.
Is hepatic differentiation of embryonic stem cells induced by valproic acid and cytokines?
Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure.
Paradoxical protein might prevent cancer
One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell.
U of M researchers find 2 units of umbilical cord blood reduce risk of leukemia recurrence
A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease returning.
The use of stem cells in regenerative medicine may also be detrimental for health
The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis.
Penn Study Provides First Clear Idea of How Rare Bone Disease Progresses
An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton.
Iowa State University researcher discovers key to vital DNA, protein interaction
A researcher at Iowa State University has discovered how a group of proteins from plant pathogenic bacteria interact with DNA in the plant cell, opening up the possibility for what the scientist calls a "cascade of advances."
Scientists successfully reprogram blood cells
Researchers have transplanted genetically modified hematopoietic stem cells into mice so that their developing red blood cells produce a critical lysosomal enzyme -preventing or reducing organ and central nervous system damage from the often-fatal genetic disorder Hurler's syndrome.
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