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New research on pre-eclampsia in mice may have important implications for humans
July 28, 2008In a new March of Dimes-funded study of pre-eclampsia, a serious and potentially deadly disorder that affects about 5 percent of pregnancies, researchers have found results in mice that may have important implications for diagnosis and treatment in humans.
Yang Xia, M.D., Ph.D., and Rodney E. Kellems, Ph.D., Department of Biochemistry and Molecular Biology; and Susan M. Ramin, M.D., Department of Obstetrics, Gynecology and Reproductive Science, all at the University of Texas-Houston Medical School, and colleagues report today in the journal Nature Medicine that they induced pre-eclampsia in mice by injecting them with certain human autoantibodies that have been found in women with pre-eclampsia. The mice showed multiple features of the disorder, including dangerously high blood pressure, protein in the urine, and placental abnormalities. Then the researchers gave the mice a substance that blocks the action of the autoantibodies; this prevented the development of pre-eclampsia.
The investigators say they demonstrated an important pathway of pre-eclampsia as well as a potential new approach to diagnosis and treatment.
Pre-eclampsia may require pre-term delivery (birth before 37 completed weeks gestation) to prevent severe complications to mother and baby, because delivery is the only cure for the disorder.
Preterm birth is a serious and costly health problem and the leading cause of death in the first month of life. More than a half million babies - one out of every eight - are born too soon each year in the United States. Babies who survive face the risk of serious life-long health problems including learning disabilities, cerebral palsy, blindness, hearing loss, and other chronic conditions including asthma. Even infants born just a few weeks too soon have a greater risk of breathing problems, feeding difficulties, temperature instability (hypothermia), jaundice and delayed brain development.
The March of Dimes also is helping to support a large World Health Organization study to evaluate whether a new screening test is in fact a reliable predictor of the development of pre-eclampsia, as well as the feasibility of doing testing in developing nations where pre-eclampsia causes a significant number of deaths among pregnant women and babies.
March of Dimes Foundation
Pre-eclampsia may require pre-term delivery (birth before 37 completed weeks gestation) to prevent severe complications to mother and baby, because delivery is the only cure for the disorder.
Preterm birth is a serious and costly health problem and the leading cause of death in the first month of life. More than a half million babies - one out of every eight - are born too soon each year in the United States. Babies who survive face the risk of serious life-long health problems including learning disabilities, cerebral palsy, blindness, hearing loss, and other chronic conditions including asthma. Even infants born just a few weeks too soon have a greater risk of breathing problems, feeding difficulties, temperature instability (hypothermia), jaundice and delayed brain development.
The March of Dimes also is helping to support a large World Health Organization study to evaluate whether a new screening test is in fact a reliable predictor of the development of pre-eclampsia, as well as the feasibility of doing testing in developing nations where pre-eclampsia causes a significant number of deaths among pregnant women and babies.
March of Dimes Foundation
Pre-eclampsia Current Events and Pre-eclampsia News RSSFaithful mothers have healthier babies
Faculty of 1000 reviewers examine a study from New Zealand on whether prolonged exposure to the father's semen protects new mothers against pre-eclampsia and having an undersized baby
Pregnant women risk early delivery from using psychiatric medication
The odds triple for premature child delivery pregnant women with a history of depression who used psychiatric medication, according to a new study.
New link between pre-eclampsia and diet
A chemical compound found in unpasteurised food has been detected in unusually high levels in the red blood cells of pregnant women with the condition pre-eclampsia.
Stuff of stink bombs investigated for role in pregnancy
Scientists at the University of Leicester are investigating how the stuff of stink bombs and flatulence could play a critical role in the human reproductive system.
Obesity raises risk of complications in pregnancy, study shows
Expectant mothers who are obese are much more likely to suffer from minor complications such as heart burn and chest infections during pregnancy, a study suggests.
Women with endometriosis need special care during pregnancy to avoid risk of premature birth
The largest study to date of endometriosis in pregnant women has found that the condition is a major risk factor for premature birth.
Ben-Gurion U researchers -- bariatric surgery minimizes pregnancy complications for obese women
Women who undergo bariatric surgery to treat obesity will reduce the risk of medical and obstetric complications when they become pregnant, according to a study by researchers from Ben-Gurion University of the Negev's (BGU) Faculty of Health Sciences.
Pregnancy disorder signals need to screen for heart disease, study shows
High blood pressure experienced during pregnancy could be a woman's earliest warning that she is at risk of developing heart disease - the number one killer of Canadian women - says Queen's University professor of Obstetrics and Gynecology, Graeme Smith.
Clues to ancestral origin of placenta emerge in Stanford study
Researchers at the Stanford University School of Medicine have uncovered the first clues about the ancient origins of a mother's intricate lifeline to her unborn baby, the placenta, which delivers oxygen and nutrients critical to the baby's health.
Smoking during pregnancy can put mums and babies at risk
Pregnant women who suffer from the high risk condition pre-eclampsia - which leads to the death of hundreds of babies every year - are putting the lives of their unborn children at significantly increased risk if they continue to smoke during pregnancy.
More Pre-eclampsia Current Events and Pre-eclampsia News Articles
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Pre-eclampsia: Etiology and Clinical Practice by Fiona Lyall (Editor), Michael Belfort (Editor) Pre-eclampsia is one of the leading causes of death and disability in mothers and babies. Over four million women worldwide will develop the disorder every year. This book, written by an international team of experts, focuses on both the scientific basis of pre-eclampsia and its management. The basic science section contains up-to-date reviews of the most exciting research developments in pre-eclampsia. The clinical chapters provide a comprehensive review of the pertinent literature, highlighting recent data and new ideas or developments in current management. There is a section in each chapter (where relevant) that deals with practical management, giving clinicians a formulated treatment plan that they can implement directly. The book will be of interest to all professionals interested... |
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Omron Elite 7300W Womens Avanced Blood Pressure Monitor by Omron FDA approved for women during pregnancy. Clinically validated for use by pregnant women, who are at significant risk for high blood pressure and pre-eclampsia |
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Pre-Eclampsia: The Hypertensive Disease of Pregnancy by Ian Macgillivray (Author) | |
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Baby Nathan by Denise Davis (Author) Denise Davis, MSW, LSW, was born in Hammond, Indiana, in 1972. She was raised by a single mother since the age of ten when her father died in a tragic accident. Focusing on her academics, she worked hard during her school years and earned a master’s degree in social work from Loyola University in 2002. She currently works in Merrillville, Indiana, providing psychotherapy to children and adolescents. She is a wife and mother of four children, one of which was a stillborn twin named Nathan. This is Nathan’s story, how his short life and death sent Denise on the most challenging journey of her life. |
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Recurrent Miscarriage And Pre-eclampsia: The Roles Played By The Immune System And Antioxidants by Rhoda Wilson (Author) This book examines the role of antioxidants and of the immune system in the pathogenesis of pre-eclampsia and recurrent miscarriage. Whilst many papers have discussed the role of antioxidants in pre-eclampsia and, that of the immune system, hitherto publication has not considered the two simultaneously. The role of the immune system in recurrent miscarriage has been the subject of many papers but whether antioxidants play a part in miscarriage has been less well studied. In many ways the problems encountered in the two disorders are similar, and this book brings them together. |
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Pre-eclampsia: Webster's Timeline History, 1951 - 2007 by Icon Group International (Author) Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Pre-eclampsia," including when used in literature (e.g. all authors that might have Pre-eclampsia in their name). As such, this book represents the largest compilation of timeline events associated with Pre-eclampsia when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social... |
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Pre-eclampsia: risks at antenatal booking and recurrence across generations.(ROUND UP: Research): An article from: Reproductive Health Matters by Gale Reference Team (Author) This digital document is an article from Reproductive Health Matters, published by Thomson Gale on November 1, 2006. The length of the article is 510 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Pre-eclampsia: risks at antenatal booking and recurrence across generations.(ROUND UP: Research) Author: Gale Reference Team Publication: Reproductive Health Matters (Magazine/Journal) Date: November 1, 2006 Publisher: Thomson Gale Volume: 14 Issue: 28 Page: 214(1) Distributed by Thomson... | |
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Pre-eclampsia: The Facts: The Hidden Threat to Pregnancy (Oxford Medical Publications) by Chris Redman (Author), Isabel Walker (Author) Pre-eclampsia is the development of hypertension during pregnancy and the most common and the most potentially serious complication of pregnancy. It affects one out of every ten pregnancies, yet there is little known about the disease. This work informs pregnant women, family practitioners, and midwives of this usually symptomless, but often dangerous condition. It includes several illuminating case histories. Written by an expert in the field and a medical journalist who has suffered from pre-eclampsia, this book is a comprehensive and accessible portrait of the disease. It details all that is currently known about the origins and treatment of pre-eclampsia, and also provides advice for pregnant women. | |
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Embarazadas: cuidado con la preclampsia.(TT: Pregnant women: carefull with pre-eclampsia): An article from: Contenido by Inés Olguín (Author) This digital document is an article from Contenido, published by Editorial Contenido, S.A. de C.V. on November 1, 1997. The length of the article is 1077 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Embarazadas: cuidado con la preclampsia.(TT: Pregnant women: carefull with pre-eclampsia) Author: Inés Olguín Publication: Contenido (Magazine/Journal) Date: November 1, 1997 Publisher: Editorial Contenido, S.A. de C.V. Issue: n413 Page: p70(3) Distributed by Thomson... | |
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Antiretroviral therapy in HIV positive pregnant women and risk of pre-eclampsia, fetal death, preterm birth and low birthweight.(ROUND UP: Maternal Mortality ... An article from: Reproductive Health Matters by Gale Reference Team (Author) This digital document is an article from Reproductive Health Matters, published by Thomson Gale on November 1, 2007. The length of the article is 447 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Antiretroviral therapy in HIV positive pregnant women and risk of pre-eclampsia, fetal death, preterm birth and low birthweight.(ROUND UP: Maternal Mortality and Morbidity)(Human immunodeficiency virus) Author: Gale Reference Team Publication: Reproductive Health Matters (Magazine/Journal) Date: November 1, 2007 Publisher: Thomson Gale Volume: 15 Issue: 30 Page:... |
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