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New research on pre-eclampsia in mice may have important implications for humans
July 28, 2008In a new March of Dimes-funded study of pre-eclampsia, a serious and potentially deadly disorder that affects about 5 percent of pregnancies, researchers have found results in mice that may have important implications for diagnosis and treatment in humans.
Yang Xia, M.D., Ph.D., and Rodney E. Kellems, Ph.D., Department of Biochemistry and Molecular Biology; and Susan M. Ramin, M.D., Department of Obstetrics, Gynecology and Reproductive Science, all at the University of Texas-Houston Medical School, and colleagues report today in the journal Nature Medicine that they induced pre-eclampsia in mice by injecting them with certain human autoantibodies that have been found in women with pre-eclampsia. The mice showed multiple features of the disorder, including dangerously high blood pressure, protein in the urine, and placental abnormalities. Then the researchers gave the mice a substance that blocks the action of the autoantibodies; this prevented the development of pre-eclampsia.
The investigators say they demonstrated an important pathway of pre-eclampsia as well as a potential new approach to diagnosis and treatment.
Pre-eclampsia may require pre-term delivery (birth before 37 completed weeks gestation) to prevent severe complications to mother and baby, because delivery is the only cure for the disorder.
Preterm birth is a serious and costly health problem and the leading cause of death in the first month of life. More than a half million babies - one out of every eight - are born too soon each year in the United States. Babies who survive face the risk of serious life-long health problems including learning disabilities, cerebral palsy, blindness, hearing loss, and other chronic conditions including asthma. Even infants born just a few weeks too soon have a greater risk of breathing problems, feeding difficulties, temperature instability (hypothermia), jaundice and delayed brain development.
The March of Dimes also is helping to support a large World Health Organization study to evaluate whether a new screening test is in fact a reliable predictor of the development of pre-eclampsia, as well as the feasibility of doing testing in developing nations where pre-eclampsia causes a significant number of deaths among pregnant women and babies.
March of Dimes Foundation
Pre-eclampsia may require pre-term delivery (birth before 37 completed weeks gestation) to prevent severe complications to mother and baby, because delivery is the only cure for the disorder.
Preterm birth is a serious and costly health problem and the leading cause of death in the first month of life. More than a half million babies - one out of every eight - are born too soon each year in the United States. Babies who survive face the risk of serious life-long health problems including learning disabilities, cerebral palsy, blindness, hearing loss, and other chronic conditions including asthma. Even infants born just a few weeks too soon have a greater risk of breathing problems, feeding difficulties, temperature instability (hypothermia), jaundice and delayed brain development.
The March of Dimes also is helping to support a large World Health Organization study to evaluate whether a new screening test is in fact a reliable predictor of the development of pre-eclampsia, as well as the feasibility of doing testing in developing nations where pre-eclampsia causes a significant number of deaths among pregnant women and babies.
March of Dimes Foundation
Pre-eclampsia Current Events and Pre-eclampsia News RSSClues to ancestral origin of placenta emerge in Stanford study
Researchers at the Stanford University School of Medicine have uncovered the first clues about the ancient origins of a mother's intricate lifeline to her unborn baby, the placenta, which delivers oxygen and nutrients critical to the baby's health.
Smoking during pregnancy can put mums and babies at risk
Pregnant women who suffer from the high risk condition pre-eclampsia - which leads to the death of hundreds of babies every year - are putting the lives of their unborn children at significantly increased risk if they continue to smoke during pregnancy.
Herpes virus link to complications in pregnancy
Researchers at Adelaide's Women's & Children's Hospital and the University of Adelaide, Australia, have made a world-first discovery that links viral infection with high blood pressure during pregnancy and pre-term birth.
Breakthrough in pre-eclampsia test
A team at the University of Leeds has discovered a way of diagnosing pre-eclampsia, a condition which affects almost one in ten pregnant women and accounts for up to 15% of all premature deliveries.
New studies add weight to link between pre-eclampsia and heart disease
Two studies, published together on bmj.com today, add further weight to the theory that pre-eclampsia and cardiovascular diseases may share common causes or mechanisms.
Editorial: Weight and pregnancy
Gaining or losing weight in between pregnancies can have major health implications for an unborn baby, warn two senior obstetricians in today's BMJ.
Simple home spit test to spot deadly pre-eclampsia
A simple spit test designed to detect pre-eclampsia in the early stages is being trialed in a UK hospital, reports Cath O'Driscoll in Chemistry & Industry, the magazine of the SCI.
Gaining weight between pregnancies could lead to pregnancy complications
A number of studies over the years have found an association between obesity and pregnancy complications, including pre-eclampsia (hypertension), gestational diabetes and stillbirth, but there was little evidence of a direct, cause-and-effect relationship.
Researchers Reveal How Air Pollutant Helps Pregnant Women with Hypertension
Nitric oxide (NO) is best known as an air pollutant produced by vehicle emissions and power plants but for pregnant women it is a crucial compound required to avoid hypertension and pre-eclampsia.
Carbon monoxide may help prevent debilitating pregnancy condition
New findings by Queen's University researchers suggest that administering low doses of carbon monoxide to pregnant women may help prevent the potentially damaging effects to mother and baby of pre-eclampsia.
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