 |
|
Going from ulcers to cancer
August 25, 2008Appearing in JBC online Aug. 22
Researchers have uncovered a big clue as to why some of the bacteria that cause stomach ulcers pose a greater risk for serious problems like stomach cancer than others; it turns out these bacteria can exploit the surrounding stomach cells to protect them from the immune system.
Helicobacter pylori is a bacterial strain that can infect the human stomach and induce inflammation, ulcers, and potentially even stomach cancer. However, only a small fraction of H. pylori infections ultimately lead to cancer, leading researchers to figure out what biological events will trigger this path.
One type of H. pylori strain that seems to increase disease risk is the cag+ strain, which contains a set of proteins that allows it to inject bacterial proteins into cells following attachment to the stomach lining; this interaction between bacteria and gastric cells may be a key contributor to chronic damage.
Richard Peek and colleagues investigated a cag+ strain in mouse models of H. pylori infection and found that a protein called CagE could induce gastric cells to turn on a receptor called Decay-accelerating factor (DAF); DAF acts to remove nearby immune proteins that can kill cells to prevent unwanted immune damage.
In essence, the bacteria use the DAF receptor on the host cell they're attached to like a bodyguard to protect them from the immune system. Peek and colleagues also note that by continually inducing DAF expression, H. pylori creates an environment of persistent inflammation that can reduce the threshold required for more serious diseases to develop.
American Society for Biochemistry and Molecular Biology
One type of H. pylori strain that seems to increase disease risk is the cag+ strain, which contains a set of proteins that allows it to inject bacterial proteins into cells following attachment to the stomach lining; this interaction between bacteria and gastric cells may be a key contributor to chronic damage.
Richard Peek and colleagues investigated a cag+ strain in mouse models of H. pylori infection and found that a protein called CagE could induce gastric cells to turn on a receptor called Decay-accelerating factor (DAF); DAF acts to remove nearby immune proteins that can kill cells to prevent unwanted immune damage.
In essence, the bacteria use the DAF receptor on the host cell they're attached to like a bodyguard to protect them from the immune system. Peek and colleagues also note that by continually inducing DAF expression, H. pylori creates an environment of persistent inflammation that can reduce the threshold required for more serious diseases to develop.
American Society for Biochemistry and Molecular Biology
Ulcers Current Events and Ulcers News RSSPitt, US Army team designs new strategy to find drugs to treat neglected infection
Using an unconventional approach that they designed, University of Pittsburgh drug discoverers and their collaborators at Walter Reed Army Institute of Research have identified compounds that hold promise for treating leishmaniasis, a parasitic infection that many consider one of the world's most overlooked diseases.
Surgeons at Boston Medical Center offering new procedure for acid reflux/GERD
Boston Medical Center (BMC) surgeons are now offering patients an incisionless alternative to laparoscopic and traditional surgery for treatment of acid reflux or GERD.
Will genomics help prevent the next pandemic?
This week, the Public Library of Science, an open-access publisher, presents the "Genomics of Emerging Infectious Disease," a collection of essays, perspectives, and reviews that explores how genomics-with all its associated tools and techniques-can provide insights into our understanding of emerging infectious disease.
Lifestyle changes remain important in fighting peripheral arterial disease
Modifying the risk of peripheral arterial disease (or PAD)-with healthy lifestyle changes-remains vital to one's health, note researchers in a recent issue of the Journal of Vascular and Interventional Radiology.
Taking sharper aim at stomach ulcer bacteria
Scientists are reporting discovery of a much sought after crack in the armor of a common microbe that infects the stomachs of one-sixth of the world's population, causing stomach ulcers and other diseases.
Popular stomach acid reducer triples risk of developing pneumonia
A popular stomach-acid reducer used to prevent stress ulcers in critically ill patients needing breathing machine support increases the risk of those patients contracting pneumonia threefold, according to researchers at Wake Forest University School of Medicine.
International conference on endothelin
One of the most intriguing developments in recent medical science is the discovery of the human chemical endothelin (ET).
Endoscopy within 24 hours shows better outcomes in elderly with peptic ulcer bleeding
A new study shows that elderly patients who underwent endoscopy within one day of presentation for peptic ulcer bleeding had a two-day shorter hospital stay and were less likely to require upper gastrointestinal surgery than patients who did not receive endoscopy within the first day of presentation.
Uncovering the secrets of ulcer-causing bacteria
A team of researchers from Boston University, Harvard Medical School and Massachusetts Institute of Technology recently made a discovery that changes a long held paradigm about how bacteria move through soft gels.
ADA publishes practice guidelines for nutrition care for patients with spinal cord injury
The American Dietetic Association has published new evidence-based nutrition practice guidelines for registered dietitians on nutrition care for patients with spinal cord injury.
More Ulcers Current Events and Ulcers News Articles
 |
Ulcer Ease Anesthetic Mouth Rinse, 6 fl oz (178 ml) by UlcerEase For prompt relief of pain due to mouth and upper throat irritations. Contains: No sugar; No alcohol; No artificial dyes or colorings. Pleasant to use. |
 |
Why Zebras Don't Get Ulcers, Third Edition by Robert M. Sapolsky (Author) how stress affects sleep and addiction, as well as new insights into anxiety and personality disorder and the impact of spirituality on managing stress. As Sapolsky explains, most of us do not lie awake at night worrying about whether we have leprosy or malaria. Instead, the diseases we fear-and the ones that plague us now-are illnesses brought on by the slow accumulation of damage, such as heart disease and cancer. When we worry or experience stress, our body turns on the same physiological responses that an animal's does, but we do not resolve conflict in the same way-through fighting or fleeing. Over time, this activation of a stress response makes us literally sick. Combining cutting-edge research with a healthy dose of good humor and practical advice, Why Zebras Don't Get Ulcers... |
 |
Alternative Health & Herbs Remedies Nerves, Stomach, Ulcers, 1-Ounce Bottle (Pack of 2) by Alternative Health & Herbs Remedies To help soothe and heal the stomach when ulcers are present. Also useful for colitis, stomach irritations, and sour stomach. |
![ULCER (HELICOBACTER PYLORI) GIANT MICROBE PLUSH [Toy]](http://ecx.images-amazon.com/images/I/21nsEA16ptL._SL160_.jpg) |
ULCER (HELICOBACTER PYLORI) GIANT MICROBE PLUSH [Toy] by Giant Microbes GIANTmicrobes are fun and educationala great way to learn about various health topics and the microscopic critters that are found in and around us. Each microbe character is 5-7 in size--over a million times their actual size! Perfect for teachers, parents and budding scientiststhey also make humorous gifts. Each microbe comes with an information tag including scientific name, an image of the actual microbe, and a mini history and science lesson. Not suitable for children under 3 years. Our products are made by top manufacturers who care about toy safety, quality and value. Your order will ship factory fresh directly from our warehouse to your door. We carefully inspect and beautifully package every order before shipment to ensure that you receive high quality products that are... |
 |
The principles of surgery: as they relate to wounds, ulcers, etc by Old Classics |
 |
Healthy Digestion the Natural Way: Preventing and Healing Heartburn, Constipation, Gas, Diarrhea, Inflammatory Bowel and Gallbladder Diseases, Ulcers, Irritable Bowel Syndrome, and More by D. Lindsey Berkson (Author) A complete guide to healing your digestive problems, once and for all—safely, inexpensively, naturally Good digestion is fundamental to good health, and even such common problems as chronic heartburn and gas can have harmful effects on virtually every cell in your body. Quick fixes such as over-the-counter and prescription medications don’t address the real causes of the problems: they only mask symptoms. Nature, on the other hand, offers a variety of gentle, readily available remedies that not only treat underlying digestive problems but also help to promote overall well-being. Learn about natural solutions and how to put them to work for you in Healthy Digestion the Natural Way. Dr. D. Lindsey Berkson clearly and simply explains the normal digestive processes and what can happen to... |
 |
6 pack UlcerGard (omeprazole) Oral Paste Syringe (13.68 gm) by Merial UlcerGard New non-prescription preventive for Equine Gastric Ulcer Syndrome. Contains omeprazole, which suppresses acid production in a horse's stomach, and at the recommended dosage, effectively prevents the onset of ulcers. Dosage during periods of stress is ¼ tube daily for horses weighing between 600 and 1200 lbs. For horses over 1200 lbs, ½ tube daily is recommended. Cinnamon flavored. |
 |
Giant Microbes Ulcer Microbe by Giant Microbes Giant Microbes Ulcer Microbe |
 |
Pressure Ulcers |
 |
Hot Skin And Cold Cash by The Ulcers |
| © 2009 BrightSurf.com |