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New study finds that add-on therapy improves depressive symptoms in bipolar disorder
September 03, 2008Lingering depression is a serious and common problem in bipolar disorder, and does not resolve well with existing treatments. Because individuals with both depression and bipolar disorder experience a glutathione deficiency, an antioxidant that protects cells from toxins, researchers in a new study scheduled for publication in the September 15th issue of Biological Psychiatry sought to evaluate whether N-acetyl cysteine (NAC), an over-the-counter supplement that increases brain glutathione, might help alleviate depressive symptoms.
Dr. Michael Berk and colleagues, in a randomized, double-blind, placebo-controlled trial, evaluated the mood symptoms of individuals with bipolar disorder, half of whom received placebo and half of whom received NAC, as an add-on therapy to their usual treatment. Over the 24 weeks of the study, NAC was well tolerated, and induced a marked and significant improvement in depressive symptoms. Ashley Bush, M.D., Ph.D., the article's corresponding author, further explains: "Glutathione is the brain's primary antioxidant defense, and there is evidence of increased oxidative stress in bipolar disorder. Therefore, we studied the potential benefit of NAC treatment in bipolar disorder and found that it impressively remedied residual depressive symptoms."
Elsevier
Bipolar Disorder Current Events and Bipolar Disorder News RSSGreater certainty in monitoring 3 therapeutic medications is facilitated by new CRMs
To help bring greater certainty to the measurement of medication levels in a patient's bloodstream for three drugs with narrow therapeutic ranges, the U.S. Pharmacopeial Convention (USP) is releasing new certified reference materials (CRMs).
Full recovery now possible for an 'untreatable' mental illness
Patients coping with the chaos and misery of Borderline Personality Disorder now have reason for strong confidence in making major life changes through a new treatment, Schema Therapy.
Faulty body clock may make kids bipolar
Malfunctioning circadian clock genes may be responsible for bipolar disorder in children. Researchers writing in the open access journal BMC Psychiatry found four versions of the regulatory gene RORB that were associated with pediatric bipolar disorder.
Autism Speaks' genetic resource exchange, tissue program support findings published in Nature
Autism Speaks' Autism Genetic Resource Exchange (AGRE) and the Autism Tissue Program (ATP) continue to play an integral role in continuing genetic research and new findings in the complex autism inheritance and causation puzzle.
UNC study pinpoints gene controlling number of brain cells
In populating the growing brain, neural stem cells must strike a delicate balance between two key processes - proliferation, in which the cells multiply to provide plenty of starting materials - and differentiation, in which those materials evolve into functioning neurons.
Young Adults May Outgrow Bipolar Disorder
Bipolar disorder, or manic-depression, causes severe and unusual shifts in mood and energy, affecting a person's ability to perform everyday tasks. With symptoms often starting in early adulthood, bipolar disorder has been thought of traditionally as a lifelong disorder.
Mad Genius: Study Suggests Link Between Psychosis and Creativity
Vincent van Gogh cut off his ear. Sylvia Plath stuck her head in the oven. History teems with examples of great artists acting in very peculiar ways. Were these artists simply mad or brilliant? According to new research reported in Psychological Science, a journal of the Association for Psychological Science, maybe both.
Sleep patterns in children and teenagers could indicate risk for depression, researcher finds
Sleep patterns can help predict which adolescents might be at greatest risk for developing depression, a researcher at UT Southwestern Medical Center has found in a five-year study.
Sleep patterns in children and teenagers could indicate risk for depression, researcher finds
Sleep patterns can help predict which adolescents might be at greatest risk for developing depression, a researcher at UT Southwestern Medical Center has found in a five-year study.
Invisible Ink? What Rorschach Tests Really Tell Us
One of the most well-known psychological tools is the Rorschach Inkblot Test. A viewer looks at ten inkblots, one at a time, and describes what they see.
More Bipolar Disorder Current Events and Bipolar Disorder News Articles
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The Bipolar Disorder Survival Guide: What You and Your Family Need to Know by David J. Miklowitz (Author) Thanks to sharper diagnosis and better medicine, the future is brighter for people with bipolar disorder than in past generations. But if you or someone you love is struggling with the frantic highs and crushing lows of this illness, there are still many hurdles to surmount at home, at work, and in daily life. *How can you learn to distinguish between the early warning signs of mood swings and the normal ups and downs of life? *What medications are available, and what are their side effects? *What should you do when you find yourself escalating into mania or descending into depression? *How can you get the help and support you need from family members and friends? *How can you tell your coworkers about your illness without endangering your career? In this... |
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Break the Bipolar Cycle: A Day-by-Day Guide to Living with Bipolar Disorder by Elizabeth Brondolo (Author), Xavier Amador (Author) Take control of your symptoms--and take charge of your life If you're dealing with bipolar disorder, you already know that it’s more than a cycle of “ups” and “downs.” You may also have difficulty with depression and irritability, as well as problems with weight gain, memory, and fatigue. Dealing with these day-to-day problems can sometimes seem like too much to bear. Drawing on the latest research in bipolar disorder, stress, and health, this step-by-step guide offers a complete selection of livable, workable solutions to manage bipolar disorder and helps you: Identify your symptoms Explore your treatment options Stabilize your moods Sharpen your mind Achieve your goals This isn't a one-size-fits-all guide. It's a uniquely personal... |
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Loving Someone with Bipolar Disorder by Julie A. Fast (Author), John D. Preston Psy D ABPP (Author) When a person loves someone with bipolar disorder, life can be very stressful. From medication troubles to a partner's mood swings the demands on a partner can be intense. Loving Someone with Bipolar Disorder takes a unique and practical approach to these issues. Written by an author who has bipolar disorder (and who lived with a partner who also has bipolar disorder) and a coauthor with over ten books on the topic of mental illness, the book offers specific, practical and realistic tips on how a couple can work together as a team to create a treatment plan that teaches them to live with the illness while still maintaining a loving and joyful relationship. (Though this book is written for couples, friends and family members can use the techniques in the book as well.) ... |
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Bipolar Disorder: A Guide for Patients and Families (2nd Edition) by Francis Mark Mondimore MD (Author) Bipolar disorder can be devastating. It can disrupt relationships and careers, it can wreak havoc on family life, and, when not properly treated, it can be fatal. Since 1999 this compassionate and comprehensive guide has helped tens of thousands of people cope with this complex disease. This, the second edition of Bipolar Disorder, is thoroughly updated and discusses promising new options for diagnosis and treatment along with new information on the disease's genetic components. Bipolar disorder is difficult to diagnose. Dr. Mondimore explains how symptoms fluctuate in persons with seasonal affective disorder, how they can lead to a mistaken diagnosis of attention deficit--hyperactivity disorder in children, and how they may be made worse by alcohol or drug addiction. The... |
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Bipolar Disorder: The Ultimate Guide by Sarah Owen (Author), Amanda Saunders (Author) Has someone close to you been diagnosed with Bipolar disorder? Have you been diagnosed yourself? If so, then this is the book for you. With a helpful question and answer format, this invaluable guide reveals everything about the condition, and shows how to keep it firmly under control. From how to deal with a manic episode to coping with the stigma often associated with mental illness, this guide contains the very latest research surrounding the illness that affects one in fifty of us. Including numerous real-life case studies, helpful character summaries and a full list of support organizations, this accessible blend of advice and insight will inform and empower all those who live with the bewildering turbulence of bipolar disorder. |
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Take Charge of Bipolar Disorder: A 4-Step Plan for You and Your Loved Ones to Manage the Illness and Create Lasting Stability by Julie A Fast (Author), John Preston (Author) MANAGE YOUR MOODS. IDENTIFY YOUR TRIGGERS. RECLAIM YOUR LIFE. Many people diagnosed with bipolar disorder are sent home with the name of a doctor and prescription drugs. But few are able to manage their often out-of-control emotions with medication alone. Written by Julie A. Fast, who was diagnosed with bipolar disorder at age thirty-one, and bipolar disorder specialist John Preston, PsyD, TAKE CHARGE OF BIPOLAR DISORDER offers a unique, personalized approach that teaches people with bipolar disorder and their loved ones to manage the illness and achieve daily stability. Fast and Preston's groundbreaking program combines medication and supplements, lifestyle changes, behavior modifications, and other indispensable management tools. Readers will learn how to: Understand... |
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Bipolar Disorder for Dummies by Candida Fink (Author), Joe Kraynak (Author) Bipolar Disorder affects many more people than just the 2.5 million Americans who suffer from the disease. Like depression and other serious illnesses, bipolar disorder also affects spouses, partners, family members, friends and coworkers. And, according to the Child and Adolescent Bipolar Foundation, 15% of children diagnosed with ADHD may actually be suffering from early-onset of Bipolar Disorder. Bipolar Disorder For Dummies reveals some of the causes and consequences of bipolar disorder, let you in on some crisis survival strategies, and describe ways that friends and family members can support loved ones who have the disease. The book includes an overview of the causes and symptoms of bipolar disorder, explains step-by-step how to obtain an accurate diagnosis, discusses the... |
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Cognitive-Behavioral Therapy for Bipolar Disorder, Second Edition by Monica Ramirez Basco PhD (Author), A. John Rush MD (Author) From leading scientist-practitioners, this pragmatic, accessible book provides a complete framework for individualized assessment and treatment of bipolar disorder. It addresses the complexities of working with individuals with broadly varying histories and clinical presentations, including those who have been recently diagnosed, those who are symptomatically stable, and those who struggle day to day to achieve symptom remission. Extensive case material illustrates proven strategies for conceptualizing patients' needs and working collaboratively to help them adhere to medication treatments, recognize the early warning signs of manic and depressive episodes, build coping skills, and manage specific symptoms. The second edition is a complete revision of the original volume, updated and... |
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Living Well with Depression and Bipolar Disorder: What Your Doctor Doesn't Tell You...That You Need to Know by John Mcmanamy (Author) Seven years ago, John McManamy was diagnosed with bipolar disorder. Through his successful Web site and newsletter, he has turned his struggles into a lifelong dedication to helping others battling depression and bipolar disorder reclaim their lives. In Living Well with Depression and Bipolar Disorder, he brilliantly blends the knowledge of leading expert authorities with the experiences of his fellow patients, as well as his own, and offers extensive information on: Diagnosing the problem Associated illnesses and symptoms Treatments, lifestyle, and coping The effects of depression and bipolar disorder on relationships and sex With a compassionate and eloquent voice, McManamy describes his belief that depression is a wide spectrum that reaches from occasional bouts of... |
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Sugar and Salt: My Life with Bipolar Disorder by Jane Thompson (Author) Sugar & Salt: My Life with Bipolar Disorder is the story of an ordinary person who lived with and ultimately overcame bipolar disorder (manic-depression.). She was not diagnosed until she was 37. She describes what it is like to be raised in a family overshadowed by the illness, and to try to fit in in school and to function at work with the undiagnosed disorder. The failure of a marriage and relationships are detailed, and she struggles to understand why her life is so different and so difficult, until she has a sudden revelation that something is wrong with her and that she needs help. Then comes the long fight to get treatment as she tries medication after medication after being misdiagnosed as psychotic. For five years she seeks knowledge and understanding of the disorder that makes... |
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