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Monitoring immune responses in disease
September 04, 2008A recent study (doi:10.1016/j.clim.2008.06.009) published in Clinical Immunology, the official journal of the Clinical Immunology Society (CIS), describes a new method enabling the detection of multiple parameters of single human cells. The report demonstrates the characterization of specific blood cells from an individual with type 1 diabetes, providing information about the role these cells might play in the development of the disease and during therapy.
Classification of blood cells, including B and T cells, is important for distinguishing immune responses to pathogens, allergens, or self-antigens in autoimmune diseases. Although various techniques are available to identify cell surface determinants, cytokines and antibodies secreted by blood cells, so far it has not been possible to study multiple secreted proteins while also assigning surface displayed markers to individual living cells.
A collaborative group of investigators from Harvard Medical School and Massachusetts Institute of Technology in the USA, describe how a combination of existing and enhanced immunological methods can identify and characterize rare B cells from blood of a recent onset type 1 diabetic subject.
"Although this is a small pilot study, it is a useful proof of principle for single cell interrogation methodology, which is potentially of general utility", according to immunologist Gerald Nepom from the University of Washington, School of Medicine in Seattle, USA in his commentary published in the same issue of Clinical Immunology (http://www.elsevier.com/locate/yclim).
"This article describes a very exciting new immunodiagnostic tool, potentially enabling the discovery of novel biomarkers for the pathogenesis of immunologic disorders and in monitoring therapy", said Andy Saxon", the Editor-in-Chief of the CIS journal.
Elsevier
"Although this is a small pilot study, it is a useful proof of principle for single cell interrogation methodology, which is potentially of general utility", according to immunologist Gerald Nepom from the University of Washington, School of Medicine in Seattle, USA in his commentary published in the same issue of Clinical Immunology (http://www.elsevier.com/locate/yclim).
"This article describes a very exciting new immunodiagnostic tool, potentially enabling the discovery of novel biomarkers for the pathogenesis of immunologic disorders and in monitoring therapy", said Andy Saxon", the Editor-in-Chief of the CIS journal.
Elsevier
Clinical Immunology Current Events and Clinical Immunology News RSSJohns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps
A protein known to stimulate blood vessel growth has now been found to be responsible for the cell overgrowth in the development of polyps that characterize one of the most severe forms of sinusitis, a study by Johns Hopkins researchers suggests.
Sweet -- sugared polymer a new weapon against allergies and asthma
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks.
New asthma predictors needed to determine future risk in certain patients
Screening tests used to predict asthma activity in patients may have little tracking success when applied to people with persistent disease who are adhering to their health care regimens, UT Southwestern Medical Center physician report.
UCLA scientists uncover immune system's role in bone loss
Got high cholesterol? You might want to consider a bone density test. A new UCLA study sheds light on the link between high cholesterol and osteoporosis and identifies a new way that the body's immune cells play a role in bone loss.
Milk is safe, even encouraged, for some children after treatment for milk allergy
Some children with a history of severe milk allergy can safely drink milk and consume other dairy products every day, according to research led by the Johns Hopkins Children's Center and published in the Aug. 10 online edition of the Journal of Allergy and Clinical Immunology.
Insurance, Medical Provider Do Not Assure Asthma Control
It is widely believed that providing better access to medical care can improve the health of Americans. New research at National Jewish Health indicates, however, that having insurance and a medical provider is not enough to improve asthma control among elementary and middle school students.
When children have breathing problems
Increasing numbers of children around the world are suffering from respiratory problems - coughing, wheezing and asthma attacks.
Stress and Depression Worsen Childhood Asthma, UB Researchers Show
Young people with asthma have nearly twice the incidence of depression compared to their peers without asthma, and studies have shown that depression is associated with increased asthma symptoms and, in some cases, death.
Study Characterizes Eczema Patients Most at Risk for Dangerous Viral Infections
Eczema patients at risk for serious viral infections have more severe disease, are more likely to be allergic to food and other allergens, and have a frequent history of staph infections.
Asthma rates and where you live
Neighborhoods with restaurants, entertainment, cultural facilities and ethnic diversity have lower asthma rates in the city of Chicago than neighborhoods where residents are less likely to move, and where there are more churches and not-for-profit facilities.
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