Trichoplax genome sequenced -- 'rosetta stone' for understanding evolution

September 04, 2008

New Haven, Conn. -Yale molecular and evolutionary biologists in collaboration with Department of Energy scientists produced the full genome sequence of Trichoplax, one of nature's most primitive multicellular organisms, providing a new insight into the evolution of all higher animals.

The findings reported in the online edition of the journal Nature show that while Trichoplax has one of the smallest nuclear genomes found in a multi-cellular creature, it contains signature sequences for gene regulation found in more complex animals and humans. Further, it defines Trichoplax as a branching point of animal evolution.

"Trichoplax placozoans are animals that have only four body cell types and no structured organs. They represent descendents of the oldest multi-celled animal, perhaps older even than sponges," said author Stephen Dellaporta, professor of molecular, cellular and developmental biology at Yale.

This study shows that compared with the nuclear genome of humans that contains 3 billion base pairs, Trichoplax has only 98 million. Earlier sequencing work showed that the mitochondrial genome of Trichoplax is over twice the size of those found in most animals with genes, introns and spacer sequences like the most primitive organisms.

However, size is not all that matters. DNA sequences that organisms share in common represents what was in their genomes at the time of their divergence. Unlike other model systems for studying evolution, including fruit flies and worms, even the arrangement of genes is conserved between the Trichoplax and human genomes.

"Trichoplax shares over 80 percent of its genes with humans," said Dellaporta. "We are exited to find that Trichoplax contains shared pathways and defined regulatory sequences that link these most primitive ancestors to higher animal species. The Trichoplax genome will serve as a type of "Rosetta Stone" for understanding the origins of animal-specific pathways."

Yale University

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	Mionelminthes, Trichoplax und Trematodes. Lfg 18 by H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930 Pagenstecher (Author) This book, "Mionelminthes, Trichoplax und Trematodes. Lfg 18", by Pagenstecher, H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930, is a replication of a book originally published before 1879. It has been restored by human beings, page by page, so that you may enjoy it in a form as close to the original as possible. This book was created using print-on-demand technology. Thank you for supporting classic literature.
	Mionelminthes, Trichoplax und Trematodes. Lfg 19.211 by H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930 Pagenstecher (Author) This book, "Mionelminthes, Trichoplax und Trematodes. Lfg 19.211", by Pagenstecher, H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930, is a replication of a book originally published before 1879. It has been restored by human beings, page by page, so that you may enjoy it in a form as close to the original as possible. This book was created using print-on-demand technology. Thank you for supporting classic literature.
	Mionelminthes, Trichoplax und Trematodes. Lfg 212.214 by H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930 Pagenstecher (Author) This book, "Mionelminthes, Trichoplax und Trematodes. Lfg 212.214", by Pagenstecher, H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930, is a replication of a book originally published before 1879. It has been restored by human beings, page by page, so that you may enjoy it in a form as close to the original as possible. This book was created using print-on-demand technology. Thank you for supporting classic literature.
	Mionelminthes, Trichoplax und Trematodes. Lfg 217 by H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930 Pagenstecher (Author) This book, "Mionelminthes, Trichoplax und Trematodes. Lfg 217", by Pagenstecher, H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930, is a replication of a book originally published before 1879. It has been restored by human beings, page by page, so that you may enjoy it in a form as close to the original as possible. This book was created using print-on-demand technology. Thank you for supporting classic literature.
	Mionelminthes, Trichoplax und Trematodes. Lfg 218.220 by H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930 Pagenstecher (Author) This book, "Mionelminthes, Trichoplax und Trematodes. Lfg 218.220", by Pagenstecher, H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930, is a replication of a book originally published before 1879. It has been restored by human beings, page by page, so that you may enjoy it in a form as close to the original as possible. This book was created using print-on-demand technology. Thank you for supporting classic literature.
	Mionelminthes, Trichoplax und Trematodes. Lfg 221.223 by H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930 Pagenstecher (Author) This book, "Mionelminthes, Trichoplax und Trematodes. Lfg 221.223", by Pagenstecher, H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930, is a replication of a book originally published before 1879. It has been restored by human beings, page by page, so that you may enjoy it in a form as close to the original as possible. This book was created using print-on-demand technology. Thank you for supporting classic literature.
	Mionelminthes, Trichoplax und Trematodes. Lfg 224.227 by H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930 Pagenstecher (Author) This book, "Mionelminthes, Trichoplax und Trematodes. Lfg 224.227", by Pagenstecher, H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930, is a replication of a book originally published before 1879. It has been restored by human beings, page by page, so that you may enjoy it in a form as close to the original as possible. This book was created using print-on-demand technology. Thank you for supporting classic literature.
	Mionelminthes, Trichoplax und Trematodes. Lfg 228.230 by H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930 Pagenstecher (Author) This book, "Mionelminthes, Trichoplax und Trematodes. Lfg 228.230", by Pagenstecher, H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930, is a replication of a book originally published before 1879. It has been restored by human beings, page by page, so that you may enjoy it in a form as close to the original as possible. This book was created using print-on-demand technology. Thank you for supporting classic literature.
	Mionelminthes, Trichoplax und Trematodes. Lfg 15.16 by H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930 Pagenstecher (Author) This book, "Mionelminthes, Trichoplax und Trematodes. Lfg 15.16", by Pagenstecher, H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930, is a replication of a book originally published before 1879. It has been restored by human beings, page by page, so that you may enjoy it in a form as close to the original as possible. This book was created using print-on-demand technology. Thank you for supporting classic literature.
	Mionelminthes, Trichoplax und Trematodes. Lfg 215.216 by H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930 Pagenstecher (Author) This book, "Mionelminthes, Trichoplax und Trematodes. Lfg 215.216", by Pagenstecher, H. Alexander (Heinrich Alexander), 1825-1889,Braun, Maximilian Gustav Christian Carl, 1850-1930, is a replication of a book originally published before 1879. It has been restored by human beings, page by page, so that you may enjoy it in a form as close to the original as possible. This book was created using print-on-demand technology. Thank you for supporting classic literature.