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Changes in urine could lead to BSE test for live animals
September 08, 2008Researchers have demonstrated that protein levels in urine samples can indicate both the presence and progress of Bovine Spongiform Encephalopathy (BSE) disease in cattle. Publishing their findings in BioMed Central's open access journal Proteome Science, the scientists hope that their discovery might lead to the development of a urine-based test that could prevent the precautionary slaughter of many animals as now occurs when the disease is detected.
The discovery of a new human variant of Creutzfeldt-Jakob Disease (vCJD), thought to be transmitted to humans via BSE-infected products, has resulted in many countries instituting extensive BSE testing programs for older animals. Diagnostic testing currently involves the detection of a misfolded "infectious" protein, or prion, in post-mortem brain tissue.
BSE has caused significant changes in the way beef products are produced and traded. If a simple and accurate urine test can be developed from this new knowledge, it could be performed on live animals and therefore may provide an alternative to current BSE surveillance procedures. It could also allow for the assessment of the health of breeding stock where post-mortem testing is not an option.
"We are hopeful that the knowledge that we've gained from this study will eventually lead to a live test," says Dr. David Knox, a researcher at the Public Health Agency of Canada's National Microbiology Laboratory in Winnipeg. "It may be possible to develop similar tests for other species as well, including humans with Creutzfeldt Jakob disease (CJD). A urine test for CJD could assist doctors to narrow down potential diagnoses for people with dementia".
Knox led a team of researchers who have demonstrated that the "protein profile" of cattle urine samples can indicate the presence of a BSE infection as well as how far the disease has advanced. The scientists analysed the proteins in urine samples taken from four infected and four healthy cows of the same age over the course of the disease. The proteins from the healthy and infected samples were compared using a technique called two-dimensional differential-gel electrophoresis (2-D DIGETM)
In these preliminary results a single protein was able to distinguish between those infected and control animals. In addition, the relative abundance of a set of proteins could accurately determine how far the disease had advanced.
"Our work shows that it is possible to identify biomarkers in urine that could be useful in the diagnosis and monitoring of disease progression in BSE and related transmissible spongiform encephalopathies," says Knox.
BioMed Central
"We are hopeful that the knowledge that we've gained from this study will eventually lead to a live test," says Dr. David Knox, a researcher at the Public Health Agency of Canada's National Microbiology Laboratory in Winnipeg. "It may be possible to develop similar tests for other species as well, including humans with Creutzfeldt Jakob disease (CJD). A urine test for CJD could assist doctors to narrow down potential diagnoses for people with dementia".
Knox led a team of researchers who have demonstrated that the "protein profile" of cattle urine samples can indicate the presence of a BSE infection as well as how far the disease has advanced. The scientists analysed the proteins in urine samples taken from four infected and four healthy cows of the same age over the course of the disease. The proteins from the healthy and infected samples were compared using a technique called two-dimensional differential-gel electrophoresis (2-D DIGETM)
In these preliminary results a single protein was able to distinguish between those infected and control animals. In addition, the relative abundance of a set of proteins could accurately determine how far the disease had advanced.
"Our work shows that it is possible to identify biomarkers in urine that could be useful in the diagnosis and monitoring of disease progression in BSE and related transmissible spongiform encephalopathies," says Knox.
BioMed Central
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Urine Samples Current Events and Urine Samples News RSSBPA, chemical used to make plastics, found to leach from polycarbonate drinking bottles into humans
A new study from Harvard School of Public Health (HSPH) researchers found that participants who drank for a week from polycarbonate bottles, the popular, hard-plastic drinking bottles and baby bottles, showed a two-thirds increase in their urine of the chemical bisphenol A (BPA).
Chemical can reproduce complications for some patients
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Penn Study Examines Power of Exercise to Prevent Breast Cancer
A new federally funded University of Pennsylvania School of Medicine study aims to learn whether women at high risk of breast cancer can use exercise to meaningfully reduce their risk of getting the disease.
A new approach to prostate cancer detection
On Friday 20 March, US researcher Dr. Chris Beecher from the University of Michigan gave a well attended lecture about sarcosine, an N-methyl derivative of the amino acid glycine, at the 24th Annual EAU Congress in Stockholm, Sweden.
First sister study results reinforce the importance of healthy living
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Breath or Urine Analysis May Detect Cancer, Diabetes
A future sensor may take away a patient's breath while simultaneously determining whether the patient has breast cancer, lung cancer, diabetes or asthma. A University of Missouri researcher is developing a device that will analyze breath or urine samples for volatile markers inside the body that indicate disease.
Pollution at home lurks unrecognized, instead attributed to large-scale environmental disasters
Although Americans are becoming increasingly aware of toxic chemical exposure from everyday household products like bisphenol A in some baby bottles and lead in some toys, women do not readily connect typical household products with personal chemical exposure and related adverse health effects, according to research from the December issue of the Journal of Health and Social Behavior.
Household Exposure to Toxic Chemicals Lurks Unrecognized, Researchers Find
Although Americans are becoming increasingly aware of toxic chemical exposure from everyday household products like bisphenol A in some baby bottles and lead in some toys, women do not readily connect typical household products with personal chemical exposure and related adverse health effects.
A card-swipe for medical tests
University of Utah scientists successfully created a sensitive prototype device that could test for dozens or even hundreds of diseases simultaneously by acting like a credit card-swipe machine to scan a card loaded with microscopic blood, saliva or urine samples.
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