 |
|
New once-a-week treatment for type 2 diabetes developed by Mount Sinai researcher
September 08, 2008In a study published by the Lancet journal today, Toronto researcher Dr. Daniel Drucker reported that a new once-weekly treatment for type 2 diabetes could replace the more common twice-daily injection.
"Over two million Canadians have diabetes," said Dr. Daniel Drucker, clinician-scientist and Senior Investigator at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital. "There is currently no available therapy for type 2 diabetes that patients can receive once a week."
The new treatment, Exenatide once weekly is the first in a new class of long-acting medications that mimic the action of GLP-1 (glucagon-like peptide), a naturally occurring hormone that is produced in the gut after eating. The report compared outcomes for patients self-injecting Exenatide once weekly against results from the conventional 14 injections a week, as in the currently available version of the drug known as Exenatide (Byetta).
In an international multicentre 6-month clinical trial involving 300 eligible patients, 75 per cent of study subjects who received the once-weekly Exenatide got their diabetes under control as defined by reaching target glucose levels. Patients treated with Exenatide once weekly also experienced fewer side effects, had no increased risk of hypoglycemia (decrease in blood sugars) and saw reductions in body weight.
Dr. Drucker has studied the gut hormone GLP-1 for over 20 years. Multiple drugs based on GLP-1 action are under active clinical development, and the new once-weekly treatment is expected to undergo Canadian regulatory review as early as 2009.
"Biomedical research reaches patients and improves lives," said Dr. Jim Woodgett, Director of Research at the Samuel Lunenfeld Research Institute. "Dr. Drucker is a world-expert in the development of peptide hormone-based therapies for the treatment of human disease and this is an excellent example of moving discovery through to therapeutic application."
Samuel Lunenfeld Research Institute
In an international multicentre 6-month clinical trial involving 300 eligible patients, 75 per cent of study subjects who received the once-weekly Exenatide got their diabetes under control as defined by reaching target glucose levels. Patients treated with Exenatide once weekly also experienced fewer side effects, had no increased risk of hypoglycemia (decrease in blood sugars) and saw reductions in body weight.
Dr. Drucker has studied the gut hormone GLP-1 for over 20 years. Multiple drugs based on GLP-1 action are under active clinical development, and the new once-weekly treatment is expected to undergo Canadian regulatory review as early as 2009.
"Biomedical research reaches patients and improves lives," said Dr. Jim Woodgett, Director of Research at the Samuel Lunenfeld Research Institute. "Dr. Drucker is a world-expert in the development of peptide hormone-based therapies for the treatment of human disease and this is an excellent example of moving discovery through to therapeutic application."
Samuel Lunenfeld Research Institute
Diabetes Current Events and Diabetes News RSSPediatric obesity may alter thyroid function and structure
In addition to its strong associations with hypertension, cardiovascular disease, and diabetes, pediatric obesity may induce alterations in thyroid function and structure, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
New study identifies link between Alzheimer's disease biomarkers in healthy adults
The Netherlands -- A study published in the November issue of the Journal of Alzheimer's Disease provides an insight into normal, physiological levels and association between proteins involved in development of Alzheimer's disease.
Cardiovascular disease causing increasing inequity between rich and poor
A new paper released today by The George Institute for International Health is warning a cardiovascular disease based epidemic is gaining pace among many low- and middle-income countries (LMIC), exemplified at its worst in the world's largest populated countries - China and India.
Antibiotics: Single largest class of drugs causing liver injury
Antibiotics are the single largest class of agents that cause idiosyncratic drug-induced liver injury (DILI), reports a new study in Gastroenterology, an official journal of the American Gastroenterological Association (AGA) Institute.
Persistent pollutant may promote obesity
Tributyltin, a ubiquitous pollutant that has a potent effect on gene activity, could be promoting obesity, according to an article in the December issue of BioScience.
Presence of gum disease may help dentists and physicians identify risk for cardiovascular disease
Individuals reporting a history of periodontal disease were more likely to have increased levels of inflammation, a risk factor for heart disease, compared to those who reported no history of periodontal disease.
Drink brewed tea to avoid tooth erosion
Today, the average size soft drink is 20 ounces and contains 17 teaspoons of sugar. More startling is that some citric acids found in fruit drinks are more erosive than hydrochloric or sulfuric acid-which is also known as battery acid.
Understanding how oxidative stress impairs endothelial progenitor cell function
Although its been over a decade since endothelial progenitor cells or EPCs, cells that circulate in the blood repairing and replacing the cells that line blood vessels, were identified, the field is still evolving.
Exercise helps overweight children reduce anger expression
Regular exercise seems to reduce anger expression in overweight but otherwise healthy children, researchers said.
Sealing off portion of intestinal lining treats obesity, resolves diabetes in animal model
Lining the upper portion of the small intestine with an impermeable sleeve led to both weight loss and restoration of normal glucose metabolism in an animal model of obesity-induced diabetes.
More Diabetes Current Events and Diabetes News Articles
 | The First Year: Type 2 Diabetes: An Essential Guide for the Newly Diagnosed (First Year, The) by Gretchen Becker After Gretchen Becker was diagnosed with type 2 diabetes in 1996, she educated herself on every aspect of this chronic condition — by reading medical and scientific books and journals, talking with doctors and listening to her own body. In 2001, she marshaled everything she had learned as a "patient-expert" into the first edition of this book, which she has now completely updated and revised.... |
 | Diabetes For Dummies (For Dummies (Health & Fitness)) by Alan L., MD Rubin Covers the latest glucose meters and insulin treatments The straight facts on treating diabetes successfully and living a full life Want to know how to manage diabetes? Leading diabetes expert Dr. Alan Rubin gives you reassuring, authoritative guidance in putting together a state-of-the-art treatment program. You'll learn about all the advances in monitoring glucose, the latest... |
 | Dr. Bernstein's Diabetes Solution: The Complete Guide to Achieving Normal Blood Sugars by Richard K. Bernstein The standard text on living with diabetes, newly revised and updated with all the latest scientific findings. Since its first publication in 1997, DR. BERNSTEIN'S DIABETES SOLUTION has become the treatment of choice in the medical field. In this revised and updated edition of his work, Dr. Bernstein provides an accessible, detailed guide to his revolutionary approach to normalizing... |
 | The 4-Ingredient Diabetes Cookbook: Simple, Quick, and Delicious Recipes Using Just 4 Ingredients or Less by Nancy Hughes |
 | The 30-Day Diabetes Miracle: Lifestyle Center of America's Complete Program to Stop Diabetes, Restore Health,and Build Natural Vitality by Franklin House, Stuart Seale, Ian Blake Newman A revolutionary program for combating and reversing diabetes. Over the past ten years, Lifestyle Center of America has emerged as the center in the country that offers a proven-successful program to combat diabetes-and even reverse its adverse effects on the body. Now available in book form for the first time, LCA's program enables individuals to actually get to the root of their problems by... |
 | The Official Pocket Guide to Diabetic Exchanges by American Diabetes Association Every day, every meal, millions and millions of people count on the world-famous Exchange Lists for Meal Planning to make sure they're choosing the right kinds of foods and portion sizes from the various food groups. Now people with diabetes can take the Exchange Lists with them to the grocery store or to restaurants with the Official Pocket Guide to Diabetic Exchanges. Measuring just 3.5" x 6",... |
 | Reversing Diabetes: Reduce or Even Eliminate Your Dependence on Insulin or Oral Drugs by Julian Whitaker In a completely revised and updated edition of REVERSING DIABETES, Dr Julian Whitaker offers a comprehensive life-style programme that has helped more than 10,000 diabetic patients. The good news is that many diabetics can control their condition - naturally and effectively - with diet and exercise. Along with helping to reduce or even eliminate dependancy on medication, it can help diabetics... |
 | Diabetes & Heart Healthy Meals for Two by American Diabetes Association, American Heart Association Twice as tasty . . . but with half the ingredients! People with diabetes want heart-healthy recipes, since heart disease strikes people with diabetes twice as often as the rest of the population. But they also want recipes that taste great. In Diabetes & Heart Healthy Meals for Two, the two largest health associations in America team up to provide recipes that are simple, flavorful, and... |
 | Dr. Neal Barnard's Program for Reversing Diabetes: The Scientifically Proven System for Reversing Diabetes without Drugs by Neal D. Barnard Until Dr. Barnard’s scientific breakthrough, most health professionals believed that once you developed diabetes, you were stuck with it—and could anticipate one complication after another, from worsening eyesight and nerve symptoms to heart and kidney problems. But as this groundbreaking work reveals, this simply is not true. In a series of studies—the most recent funded by the National... |
 | Betty Crocker's Diabetes Cookbook: Everyday Meals, Easy as 1-2-3 by Betty Crocker Editors At last! This special cookbook puts flavor and choice back on the menu for people with diabetes and their families Betty Crocker, America's most trusted friend in the kitchen, has teamed up with the International Diabetes Center (IDC)--one of the leading medical centers--to create an indispensable source of easy-to-make recipes and up-to-the-minute food and nutrition information for the... |
| © 2008 BrightSurf.com |