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Anti-inflammatory drugs may mask prostate cancer marker
September 08, 2008Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, may reduce serum levels of the prostate biomarker, PSA (prostate specific antigen), and hence may alter the detection of prostate cancer in individuals who take these medications. That is the conclusion of a new study in the October 15, 2008 issue of CANCER, a peer reviewed journal of the American Cancer Society.
Chronic inflammation has been linked to many different types of malignancies, including prostate cancer. Researchers suspect that inflammation associated with prostate cancer may occur through a variety of mechanisms such as infection, hormonal changes, physical trauma, urine reflux, and dietary habits. Studies have shown that cyclooxygenase (COX) enzymes, which are inhibited by NSAIDs, play an important role in inflammation. In addition, several reviews have indicated that NSAID use is associated with a lower incidence of prostate cancer.
However, there is little data on the precise relationship between NSAID use and levels of PSA, a commonly measured marker used in prostate cancer screening. For their study, led by Dr. Singer of the University of Rochester Medical Center, researchers compared blood PSA levels and NSAID and acetaminophen consumption in a large group of men in the United States.
The investigators determined PSA levels in 1,319 men over the age of 40 years who participated in the 2001-2002 National Health and Nutrition Examination Survey (NHANES), a massive health census conducted by the Centers for Disease Control and Prevention. Individuals who used NSAIDs regularly had PSA levels that were approximately 10 percent lower compared to men who did not take these drugs.
The investigators say their study suggests that regular NSAID consumption may reduce serum PSA levels. What impact this may have on the development of prostate cancer, irrespective of PSA, is unclear.
"Given the widespread consumption of NSAIDs and the regular use of PSA for the assessment of prostate cancer risk, the potential implications of our findings may be substantial and warrant further investigation," the authors wrote.
American Cancer Society
The investigators determined PSA levels in 1,319 men over the age of 40 years who participated in the 2001-2002 National Health and Nutrition Examination Survey (NHANES), a massive health census conducted by the Centers for Disease Control and Prevention. Individuals who used NSAIDs regularly had PSA levels that were approximately 10 percent lower compared to men who did not take these drugs.
The investigators say their study suggests that regular NSAID consumption may reduce serum PSA levels. What impact this may have on the development of prostate cancer, irrespective of PSA, is unclear.
"Given the widespread consumption of NSAIDs and the regular use of PSA for the assessment of prostate cancer risk, the potential implications of our findings may be substantial and warrant further investigation," the authors wrote.
American Cancer Society
Prostate Cancer Current Events and Prostate Cancer News RSSDrop in cancer deaths tied primarily to gains in behavior and screening
Improvements in behavior and screening have contributed greatly to the 13 percent decline in cancer mortality since 1990, with better cancer treatments playing a supporting role, according to new research from David Cutler of Harvard University.
Prostate cancer spurs new nerves
Prostate cancer - and perhaps other cancers - promotes the growth of new nerves and the branching axons that carry their messages, a finding associated with more aggressive tumors, said researchers from Baylor College of Medicine in the first report of the phenomenon that appears today in the journal Clinical Cancer Research.
Relationship between prostate information and lower urinary-tract symptoms evident
In the December issue of European Urology (http://www.elsevier.com/locate/eururo) Dr. Curtis Nickel and associates report on the evidence of a relationship between prostate inflammation and lower urinary tract symptoms (LUTS) in men enrolled in the REDUCE trial.
A card-swipe for medical tests
University of Utah scientists successfully created a sensitive prototype device that could test for dozens or even hundreds of diseases simultaneously by acting like a credit card-swipe machine to scan a card loaded with microscopic blood, saliva or urine samples.
Media coverage of lung cancer is increasing, and increasingly negative, new report shows
CancerCare today announced that despite an overall increase in news reporting on lung cancer, the overall tone of lung cancer media coverage has become significantly more negative.
Supercomputer provides massive computational boost to biomedical research at TGen
In less time than the blink of an eye, the Translational Genomics Research Institute's new supercomputer at Arizona State University can do operations equal to every dollar in the recent Wall Street bailout.
Prostate cancer gene test provides new early detection
Prostate cancer (PCa) is one of the most common male cancers in the Western world. Currently, early detection of PCa depends on an abnormal digital rectal examination and an elevated prostate-specific-antigen (PSA) level requiring a prostate biopsy, often associated with anxiety, discomfort, complications, and heavy expenses.
New Catheter-less Technique May Ease the Pain and Discomfort of Prostate Cancer Recovery
To ease the pain of recovery following prostate cancer surgery, physician-scientists have developed an innovative and patient-friendly approach that eliminates the use of a penile urinary catheter.
Racial disparities decline for cancer in Missouri
Cancer death rates in the United States are highest among African Americans, but a new report shows that in Missouri the disparity in cancer incidence and death between African Americans and whites is declining.
OHSU Cancer Institute researchers study breathing during radiation
Oregon Health & Science University researchers have determined exactly how much breathing affects prostate movement during radiation treatment.
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