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The prevalence of hepatitis B virus infection in inflammatory bowel disease patients
September 18, 2008Patients with IBD have high risk of infection by hepatitis viruses B or C because during the course of their disease, they need blood transfusions, and sometimes surgical and endoscopic procedures for diagnosis and treatment. It is important to alert health professionals about prevention and early diagnosis of HBV infection because the steroids and immunosuppressant drugs used in IBD treatment worsen the HBV liver disease. Few studies exist to verify if these drugs influence HBV infection in IBD patients.
A research article to be published on 28 May 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Yolanda Faia Manhães Tolentino from Federal University of Rio de Janeiro evaluated the prevalence of HBV infection in IBD patients that followed up in the hospital and the possible risk factors involved in HBV infection transmission in the patients group.
It was a cross-sectional study for which 176 patients were selected according to their arrival for the medical interview. All those patients had already IBD diagnosis. The patient was interviewed and a questionnaire was filled out.
It was concluded that there was a high incidence of positive anti-HBc (17%) and positive HBsAg (2.3%) in IBD patient when compared with the overall population (7.9%).
The statistical analysis couldn't identify one possible risk factor for HBV transmission but the study found among the IBD patients 4 persons with positive HBsAg that was called inactive bearers. Studies show that immunological supression caused by steroids, immunosupressants drugs and the anti-TNF (anti necrosis antibodies - Infliximab) in IBD patients can influence the course of hepatic disease once used in HBsAg positive patients. Those drugs would take a viral replication and infection spread inside hepatocytes. It has already been related 1 case of hepatic insufficiency and death in a Crohn's disease (CD) patient and 1 case of fulminant hepatitis in rheumatoid arthritis patient both with positive HBsAg and treated with these drugs. In patients with positive HBsAg, it would be recommended the lamivudine use before immunological suppression.
After this study, it was recommended HBV vaccination for IBD patients that have never been infected by BV and also recommend lamivudine for patients with positive anti-HBc and needs to use steroids and immunomodulators.
World Journal of Gastroenterology
It was concluded that there was a high incidence of positive anti-HBc (17%) and positive HBsAg (2.3%) in IBD patient when compared with the overall population (7.9%).
The statistical analysis couldn't identify one possible risk factor for HBV transmission but the study found among the IBD patients 4 persons with positive HBsAg that was called inactive bearers. Studies show that immunological supression caused by steroids, immunosupressants drugs and the anti-TNF (anti necrosis antibodies - Infliximab) in IBD patients can influence the course of hepatic disease once used in HBsAg positive patients. Those drugs would take a viral replication and infection spread inside hepatocytes. It has already been related 1 case of hepatic insufficiency and death in a Crohn's disease (CD) patient and 1 case of fulminant hepatitis in rheumatoid arthritis patient both with positive HBsAg and treated with these drugs. In patients with positive HBsAg, it would be recommended the lamivudine use before immunological suppression.
After this study, it was recommended HBV vaccination for IBD patients that have never been infected by BV and also recommend lamivudine for patients with positive anti-HBc and needs to use steroids and immunomodulators.
World Journal of Gastroenterology
Inflammatory Bowel Disease Current Events and Inflammatory Bowel Disease News RSSAdalimumab may reduce health-care costs for Crohn's disease patients
Inflammatory bowel disease (IBD) is a term that refers to both ulcerative colitis (UC) and Crohn's disease (CD). IBD occurs most frequently in people in their late teens and twenties. There have been cases in children as young as two years old and in older adults in their seventies and eighties; men and women have an equal chance of getting the disease.
Previously unknown immune cell may help those with Crohn's and colitis
The tonsils and lymphoid tissues in the intestinal tract that help protect the body from external pathogens are the home base of a rare immune cell newly identified by researchers at Washington University School of Medicine in St. Louis.
Vitamin D deficiency common in patients with IBD, chronic liver disease
New research presented at the 73rd Annual Scientific Meeting of the American College of Gastroenterology in Orlando found patients with inflammatory bowel disease or chronic liver disease were at increased risk of developing Vitamin D deficiencies. Two separate studies highlight the importance of regular Vitamin D checkups in the evaluation of patients with certain digestive diseases.
Study confirms colonoscopy associated with reduced colorectal cancer incidence
Patients who undergo a complete negative colonoscopy have a reduced incidence of colorectal cancer, confirms a study published in Clinical Gastroenterology and Hepatology.
ASGE encourages patients to speak to their doctor about colorectal cancer screening options
Results of the National CT Colonography Trial, published in the September 18 issue of the New England Journal of Medicine, show improvements in the technology's ability to diagnose intermediate- to large-sized polyps in the colon, but this method of testing is not as effective in diagnosing small polyps
Early onset gene for inflammatory bowel diseases identified
A study of Crohn's disease and ulcerative colitis in children has identified a gene that influences whether children get these diseases early in life, and points to a potential new target for treatment.
Consumption of nuts, corn or popcorn not associated with increased risk of diverticulosis in men
Contrary to a common recommendation to avoid eating popcorn, nuts and corn to prevent diverticular complications, a large prospective study of men indicates that the consumption of these foods does not increase the risk of diverticulosis or diverticular complications, according to a study in the August 27 issue of JAMA.
New study shows health benefits of probiotic could extend to the entire body
Data from a recent study demonstrate the anti-inflammatory and pathogen protection benefits of Bifidobacterium infantis 35624 a probiotic bacterial strain of human origin.
Bone marrow stem cells may help control inflammatory bowel disease
Massachusetts General Hospital (MGH) investigators have found that infusions of a particular bone marrow stem cell appeared to protect gastrointestinal tissue from autoimmune attack in a mouse model.
Biodegradable polymers show promise for improving treatment of acute inflammatory diseases
A family of biodegradable polymers called polyketals and their derivatives may improve treatment for such inflammatory illnesses as acute lung injury, acute liver failure and inflammatory bowel disease by delivering drugs, proteins and snips of ribonucleic acid to disease locations in the body.
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