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The prevalence of hepatitis B virus infection in inflammatory bowel disease patients
September 18, 2008Patients with IBD have high risk of infection by hepatitis viruses B or C because during the course of their disease, they need blood transfusions, and sometimes surgical and endoscopic procedures for diagnosis and treatment. It is important to alert health professionals about prevention and early diagnosis of HBV infection because the steroids and immunosuppressant drugs used in IBD treatment worsen the HBV liver disease. Few studies exist to verify if these drugs influence HBV infection in IBD patients.
A research article to be published on 28 May 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Yolanda Faia Manhães Tolentino from Federal University of Rio de Janeiro evaluated the prevalence of HBV infection in IBD patients that followed up in the hospital and the possible risk factors involved in HBV infection transmission in the patients group.
It was a cross-sectional study for which 176 patients were selected according to their arrival for the medical interview. All those patients had already IBD diagnosis. The patient was interviewed and a questionnaire was filled out.
It was concluded that there was a high incidence of positive anti-HBc (17%) and positive HBsAg (2.3%) in IBD patient when compared with the overall population (7.9%).
The statistical analysis couldn't identify one possible risk factor for HBV transmission but the study found among the IBD patients 4 persons with positive HBsAg that was called inactive bearers. Studies show that immunological supression caused by steroids, immunosupressants drugs and the anti-TNF (anti necrosis antibodies - Infliximab) in IBD patients can influence the course of hepatic disease once used in HBsAg positive patients. Those drugs would take a viral replication and infection spread inside hepatocytes. It has already been related 1 case of hepatic insufficiency and death in a Crohn's disease (CD) patient and 1 case of fulminant hepatitis in rheumatoid arthritis patient both with positive HBsAg and treated with these drugs. In patients with positive HBsAg, it would be recommended the lamivudine use before immunological suppression.
After this study, it was recommended HBV vaccination for IBD patients that have never been infected by BV and also recommend lamivudine for patients with positive anti-HBc and needs to use steroids and immunomodulators.
World Journal of Gastroenterology
It was concluded that there was a high incidence of positive anti-HBc (17%) and positive HBsAg (2.3%) in IBD patient when compared with the overall population (7.9%).
The statistical analysis couldn't identify one possible risk factor for HBV transmission but the study found among the IBD patients 4 persons with positive HBsAg that was called inactive bearers. Studies show that immunological supression caused by steroids, immunosupressants drugs and the anti-TNF (anti necrosis antibodies - Infliximab) in IBD patients can influence the course of hepatic disease once used in HBsAg positive patients. Those drugs would take a viral replication and infection spread inside hepatocytes. It has already been related 1 case of hepatic insufficiency and death in a Crohn's disease (CD) patient and 1 case of fulminant hepatitis in rheumatoid arthritis patient both with positive HBsAg and treated with these drugs. In patients with positive HBsAg, it would be recommended the lamivudine use before immunological suppression.
After this study, it was recommended HBV vaccination for IBD patients that have never been infected by BV and also recommend lamivudine for patients with positive anti-HBc and needs to use steroids and immunomodulators.
World Journal of Gastroenterology
Inflammatory Bowel Disease Current Events and Inflammatory Bowel Disease News RSSLargest gene study of childhood IBD identifies 5 new genes
In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.
Gastroenterology/hepatology societies release report evaluating fellowship training curriculum
Due to the increasing complexities of treating digestive diseases, allowing gastroenterological (GI) trainee physicians the opportunity to develop enhanced abilities and experiences in specific disease areas or procedures will be a great benefit to patients, according to a "Report of the Multisociety Task Force on GI Training."
M. D. Anderson redefines screening guidelines for breast, cervical and colorectal cancers
Drawing on years of experience in cancer research and patient care, The University of Texas M. D. Anderson Cancer Center released today the most comprehensive, risk-based screening guidelines publicly available to date for breast, cervical and colorectal cancers.
Probiotic Found to Be Effective Treatment for Colitis In Mice
The probiotic, Bacillus polyfermenticus, can help mice recover from colitis, a new study has found.
The bowels of infection
Current research suggests that latent cytomegalovirus (CMV) infection may exacerbate inflammatory bowel disease (IBD). The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of The American Journal of Pathology.
Discovery of genetic defect may lead to better treatments for common gut diseases
New findings related to an uncommon genetic disorder may impact the diagnosis and treatment of inflammatory bowel disease (IBD), the most common chronic gastrointestinal illness in children and teens. Two million Americans have IBD which involves inflammation of the gastrointestinal tract.
Pitt researchers net $5 million from NIH to explore better ways to grow cells for regenerative medicine
Regenerative medicine researchers at the University of Pittsburgh received two grants totaling more than $5 million from the National Institutes of Health (NIH) to explore new methods for cultivating replacement cells from existing tissues and organs.
Visionary concept earns La Jolla Institute scientist prestigious NIH Pioneer Award
A scientist at the La Jolla Institute for Allergy & Immunology has received one of the National Institutes of Health (NIH)'s top awards -- the 2009 NIH Director's Pioneer Award.
Promising new target emerges for autoimmune diseases
University of Michigan scientists say they have uncovered a fundamentally new mechanism that holds in check aggressive immune cells that can attack the body's own cells.
Antimicrobial antibodies in celiac disease: Trick or treat?
Anti-microbial antibody formation has been reported in celiac disease.
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