What induce local recurrence of rectal carcinoma?

September 22, 2008

It is well known that local recurrence is the most important prognostic factor of rectal carcinoma. However, even after undergoing radical resection of primary tumors and lymph nodes, about 4%-50% of patients with rectal carcinoma were reportedly with local recurrence. Clinicopathologically, the risk factors of local recurrence remain unclear heretofore. Therefore, a group from Guangdong Provincial People's Hospital has recently explored the risk factors of local recurrence after curative resection in patients with middle and lower rectal carcinoma.

A research article to be published on August 14, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Wu ZY and his colleagues in the department of General Surgery, Guangdong Provincial People's Hospital reported that local recurrence occurred in 12.5% (7 of 56 cases) of patients with middle and lower rectal carcinoma.

Local recurrence was significantly associated with family history (Chi-square = 3.929, P = 0.047), high CEA level (Chi-square = 4.964, P = 0.026), cancerous perforation (Chi-square = 8.503, P = 0.004), tumor differentiation (Chi-square = 9.315, P = 0.009) and vessel cancerous emboli (Chi-square = 11.879, P = 0.001). Local recurrence rate of patients with positive circumferential resection margin was 33.3% (4/12), whereas it was 6.8% (3/44) in those with negative circumferential resection margin. The difference between these two groups was statistically significant (Chi-square = 6.061, P = 0.014). They concluded that family history, high CEA level, cancerous perforation, tumor differentiation, vessel cancerous emboli and circumferential resection margin status are significant risk factors of local recurrence after curative resection in patients with middle and lower rectal carcinoma. Local recurrence may be more frequent in patients with mesorectal metastasis, compared with patients without mesorectal metastasis. Larger sample investigations are helpful to draw a further conclusion.

In this paper, authors explore the risk factors of local recurrence after curative resection in patients with middle and lower rectal carcinoma. They demonstrated that family history, high CEA level, cancerous perforation, tumor differentiation, vessel cancerous emboli and circumferential resection margin status are significant risk factors. It's an interesting paper.

World Journal of Gastroenterology

Genotypes guide treatment for rectal carcinoma.(Gastroenterology): An article from: Internal Medicine News
by Betsy Bates (Author)

This digital document is an article from Internal Medicine News, published by Thomson Gale on May 1, 2006. The length of the article is 607 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Genotypes guide treatment for rectal carcinoma.(Gastroenterology)
Author: Betsy Bates
Publication: Internal Medicine News (Magazine/Journal)
Date: May 1, 2006
Publisher: Thomson Gale
Volume: 39 Issue: 9 Page: 60(1)

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Laryngeal metastasis from a rectal carcinoma.(Case study): An article from: Ear, Nose and Throat Journal
by Yogeetha Ramanathan (Author), Raman Rajagopalan (Author), Nazarina Abdul Rahman (Author)

This digital document is an article from Ear, Nose and Throat Journal, published by Thomson Gale on November 1, 2007. The length of the article is 802 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Laryngeal metastasis from a rectal carcinoma.(Case study)
Author: Yogeetha Ramanathan
Publication: Ear, Nose and Throat Journal (Magazine/Journal)
Date: November 1, 2007
Publisher: Thomson Gale
Volume: 86 Issue: 11 Page: 685(2)

Article Type: Case study

Distributed by Thomson...

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