 |
|
A case of false positive octreoscan in Crohn's disease
September 22, 2008Neuroendocrine tumors, such as carcinoid tumors, overexpress somatostatin receptors in their membranes. Octreotide is an analogue whose molecule is a shortened version of somatostatin's with a high affinity for these receptors. The labelled form of octreotide is able to be imaged in scans (Octreoscan) and, therefore, pathological conditions overexpressing somatostatin receptors are easily recognized in this technique. Specifically, in the case of the detection of carcinoid tumors, the Octreoscan has sensitivity nearly to 90%.
A research article to be published on September 14, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Alberto Fernandez from POVISA Hospital in Spain presents a case of a patient with a high suspicious of ileal carcinoid tumor (according to CT-scan and colonoscopy results) with a positive Octreoscan, showing uptake in the same bowel reported as pathological in CT. The patient underwent surgery and histological analysis reported Crohn's disease.
This article is the second report of CD a cause of false positive in octeotride scan. In order to explain this abnormal uptake, immunohistochemical studies were performed but the authors did not find somatostatine receptors in the sample. In the previous report published of CD mimicking an ileal carcinoid there is no evidence that somatostatin receptors were determined.
The authors did not find any explanation, and concluded encouraging physicians to be aware of CD as a cause of false positive results of Octreoscan and that further studies should be made in order to assess the possible causes of this abnormal uptake.
World Journal of Gastroenterology
The authors did not find any explanation, and concluded encouraging physicians to be aware of CD as a cause of false positive results of Octreoscan and that further studies should be made in order to assess the possible causes of this abnormal uptake.
World Journal of Gastroenterology
Targeted tumor therapy: When antagonists do the better job
Targeted tumor therapy lobs toxic payloads directly into tumors to destroy cancer cells while leaving normal cells unharmed.
Nuclear Medicine Imaging Allows Immediate Prediction of Advanced Breast Cancer Patients' Response to Hormonal Treatment
Innovative use of somatostatin receptor scintigraphy (SRS), a nuclear medicine imaging technique looking at how the body functions at the molecular level, may provide near immediate selection of breast cancer patients for endocrine therapy and offers a new tool in fighting the disease.
Suppressing growth hormone in early adulthood may prevent cancer
A modest suppression of growth hormone and related compounds beginning in early adulthood may delay the onset or progression of several types of cancer, researchers from Wake Forest University School of Medicine and other centers reported today at ENDO 2005, the annual meeting of the Endocrine Society, in San Diego.
Nature and the Nature research journals press release
[1] Predicting stroke risk in sickle cell anemia
More Somatostatin Current Events and Somatostatin News Articles
|
Somatostatin in Digestive Diseases: Improving the Treatment Options (Digestion) by C. Scarpignato (Author) Upper gastrointestinal bleeding, acute pancreatitis and postoperative complications after major pancreatic surgery have posed a persistent and often frustrating challenge to gastroenterologists, endoscopists and digestive surgeons. In this supplement, a team of international experts presents an in-depth review of the management of these difficult clinical conditions with somatostatin. After a review of the clinical pharmacology and safety of somatostatin and its analogues, an overview of the management strategies in upper gastrointestinal bleeding is presented. The place of somatostatin in the treatment of variceal and nonvariceal bleeding is then analyzed, attempting to better define the best drug and regimen. Finally the management of pancreatic fistula and prevention of postoperative... | |
|
New Uses for Somatostatin Analogues Under Investigation.: An article from: Family Practice News by Bruce Jancin (Author) This digital document is an article from Family Practice News, published by International Medical News Group on August 1, 2000. The length of the article is 978 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: New Uses for Somatostatin Analogues Under Investigation. Author: Bruce Jancin Publication: Family Practice News (Magazine/Journal) Date: August 1, 2000 Publisher: International Medical News Group Volume: 30 Issue: 15 Page: 4 Distributed by Thomson... | |
|
Somatostatin modulates the growth of salmonid fish (1). (Collegiate Communications--Undergraduate).(Brief Article): An article from: Proceedings of the North Dakota Academy of Science by Nicole Howe (Author), Darlene Knutson (Author), Jeff Kittilson (Author), Mark Sheridan (Author) This digital document is an article from Proceedings of the North Dakota Academy of Science, published by North Dakota Academy of Science on April 1, 2000. The length of the article is 584 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Somatostatin modulates the growth of salmonid fish (1). (Collegiate Communications--Undergraduate).(Brief Article) Author: Nicole Howe Publication: Proceedings of the North Dakota Academy of Science (Refereed) Date: April 1, 2000 Publisher: North Dakota Academy of Science Page: 22(1) Article Type: Brief... | |
|
Peptides in Oncology II: Somatostatin Analogues and Bombesin Antagonists (Recent Results in Cancer Research) by K. Hoffken (Editor) This volume provides an overview of the mechanisms of action and clinical efficacy of gonadotropin (luteinizing) hormone releasing (LH-RH) agonists and antagonists in hormone-sensitive neoplastic diseasis. It contains a detailed description of structural and functional aspects and presents the latest clinical results in treating benign and malignant neoplasias with LH-RH agonists as well as a detailed review of present knowledge of LH-RH antagonists. | |
 |
Somatostatin (Endocrine Updates) by Coimbatore B. Srikant (Editor) This volume presents the state-of-the-art description of the current understanding of the biology of somatostatin including its gene regulation, prosomatostatin processing, cellular effects, somatostatin receptor subtypes, mechanism of action, signal transduction, regulation of cell growth and apoptosis, design and use of receptor subtype-selective somatostatin analogs, derivatives of somatostatin analogs tagged with radionuclides/chemotoxins, and their clinical relevance in the diagnosis and treatment of cancer. Each chapter is written by expert(s) active in somatostatin research (experimental and/or clinical). It will serve as the only single one-stop source of the most up to date information on the basic and clinical aspects of the biology of somatostatin and its receptors. |
|
Somatostatin (Basic and Clinical Aspects of Neuroscience, Vol 4) by Yogesh C. Patel (Author), Robert M. Post (Contributor) This volume deals with all the known aspects of somatostatin, one of the phylogenetically oldest hormones, which is a regulatory peptide with remarkable characteristics. It is a non-classical neurotransmitter discovered less than 20 years ago in both the central nervous system and in the gastroenteropancreatic system, regulating the secretion of both pituitary and digestive hormones. It also ensures nutrient homeostasis and has therapeutic uses. | |
 |
Somatostatin Analogues: Basic and Clinical Perspectives Meeting, Sorrento, November, 1995 (Digestion) by R. Arnold (Editor) This supplement issue focuses on important aspects of somatostatin, its long-acting analogues and its receptor subtypes. It discusses the advancing knowledge about how somatostatin and its analogues act on its targets, and the implications of these advances for diagnosis and treatment. |
 |
Somatostatin: Webster's Timeline History, 1869 - 2005 by Icon Group International (Author) Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Somatostatin," including when used in literature (e.g. all authors that might have Somatostatin in their name). As such, this book represents the largest compilation of timeline events associated with Somatostatin when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social... |
|
Localization of somatostatin mRNAs in the brain and pancreas of rainbow trout (oncorhynchus mykiss) (1). (Collegiate Communications--Undergraduate).(Brief ... of the North Dakota Academy of Science by Leslie Alexander (Author), Darlene Knutson (Author), Jeffrey D. Kittilson (Author), Mark A. Sheridan (Author) This digital document is an article from Proceedings of the North Dakota Academy of Science, published by North Dakota Academy of Science on April 1, 2000. The length of the article is 530 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Localization of somatostatin mRNAs in the brain and pancreas of rainbow trout (oncorhynchus mykiss) (1). (Collegiate Communications--Undergraduate).(Brief Article) Author: Leslie Alexander Publication: Proceedings of the North Dakota Academy of Science (Refereed) Date: April 1, 2000 Publisher: North Dakota Academy of Science ... | |
 |
Somatostatin Analogs in Cancer Management (Chemotherapy Supplement) by C. Scarpignato (Editor) Although cytotoxic chemotherapy is very effective in the management of certain neoplasms such as testicular cancer, the efficacy of this therapeutic modality in the treatment of many common neoplasms is limited. Cure of macroscopic metastatic disease is extremely rare, and palliation of symptoms by chemotherapy can be problematic since the toxicity of the treatment often mitigates any improvement in the quality of life resulting from the temporary decrease in tumor burden. This situation has not only motivated attempts to develop novel cytotoxic agents, but has also stimulated research regarding innovative non-cytotoxic approaches. Amongst the various hormonal agents, increasing attention is being directed to somatostatin analogs, largely due to their antineoplastic activity in a variety... |
| © 2009 BrightSurf.com |