Breast cancer treatment resistance linked to signaling pathway

A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Dietary Modulation of Cell Signaling Pathways reviews some of these findings, focusing on nutrient-gene interactions with particular emphasis on the intracellular signaling network.

Explore a Pivotal Function for Maintaining Homeostasis

The book addresses the dietary modulation of particular gene expression systems and highlights the underlying molecular and cellular mechanisms that involve upstream signaling...

Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the...

New Antibody Microarray Tube for Cellular Localization and Signaling Pathways describes a new integrated protein biochip system including protein localization, biocomputing and signaling pathways. In the post-genome era, proteomics study for direct analysis of a group of proteins becomes more and more important. Identification of its location often provides crucial information for understanding the function or regulation of a given protein in biological pathways. The book discusses a new microarray tube with incorporation of nuclear and cytoplasmic protein purification and biocomputing technologies, intended for setting-up signaling pathways and making new discoveries.

The book is intended for researchers in the fields of medicine, biology, electronics, pharmacy, computer...

Since their discovery, Wnt signaling molecules have been shown to control key events in embryogenesis, to maintain tissue homeostasis in the adult and, when aberrantly activated, to promote human degenerative diseases and cancer, thus making them a vital area of study. Wnt Signaling: Methods and Protocols examines both biochemical assays and vertebrate and invertebrate model systems to provide a point of reference to current molecular protocols and the diverse model systems employed to study this important signaling pathway. In Volume 1, Pathway Methods and Mammalian Models, assays to measure activation of the diverse Wnt signaling pathways are explored, along with a selection of models and strategies used to study mammalian Wnt/FZD fuction, from protein-protein interaction and simple...