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Low sperm count may be associated with prenatal testosterone excess
September 23, 2008Exposure to an excess of sexual steroids, like testosterone, during fetal development may be a potential risk factor for low sperm count and motility, according to a new study accepted for publication in Endocrinology, a journal of The Endocrine Society.
"The majority of disorders affecting sperm count in humans are originated during fetal life," said Professor Sergio Recabarren of the University of Concepcion in Chillan, Chile and lead author of the study. "A developing fetus is very vulnerable to its environment, and when that environment is exposed to excess sexual steroids, it may have a significant deleterious effect on a male offspring's fertility."
Prenatal exposure to excess sexual steroids can occur in two ways, said Dr. Recabarren. First, the exposure may be a product of increased sexual steroids in the maternal environment due to a hormonal condition such as polycystic ovary syndrome. Second, humans are exposed to several industrial pollutants which can act as steroid mimics, causing the body to inhibit or accelerate native steroid production.
In this study, researchers treated pregnant sheep with 30 mg testosterone propionate twice weekly from days 30 to 90 of pregnancy and with 40 mg testosterone propionate from days 90 to 120 of pregnancy. They found a significant reduction in body weight, scrotal circumference, and sperm count in male sheep born to these mothers compared with control sheep.
"While this research involved sheep, it can certainly be argued that in humans, exposure to an excess of sexual steroids during fetal development could constitute a potential risk factor that may conduct to a low sperm count," said Dr. Recabarren.
Low sperm counts are also associated with testicular cancer, with an incidence rate 20 fold higher than men with normal sperm analysis, said Dr. Recabarren. The findings from this study highlight growing concerns of the detrimental effects of prenatal steroid excess on reduced sperm counts.
The Endocrine Society
In this study, researchers treated pregnant sheep with 30 mg testosterone propionate twice weekly from days 30 to 90 of pregnancy and with 40 mg testosterone propionate from days 90 to 120 of pregnancy. They found a significant reduction in body weight, scrotal circumference, and sperm count in male sheep born to these mothers compared with control sheep.
"While this research involved sheep, it can certainly be argued that in humans, exposure to an excess of sexual steroids during fetal development could constitute a potential risk factor that may conduct to a low sperm count," said Dr. Recabarren.
Low sperm counts are also associated with testicular cancer, with an incidence rate 20 fold higher than men with normal sperm analysis, said Dr. Recabarren. The findings from this study highlight growing concerns of the detrimental effects of prenatal steroid excess on reduced sperm counts.
The Endocrine Society
Low Sperm Count Current Events and Low Sperm Count News RSSHuman induced plurtipotent stem cells reprogrammed into germ cell precursors
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Study looks at mitochondrial variation in sperm traits and sperm competitive ability
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First case of successful ovarian tissue transplantation between two, nonidentical sisters
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New microfluidic devices found to be effective method of in-vitro fertilization in mice
Technology that more closely mirrors the natural fertilization process is showing promise as a new method of in-vitro fertilization, researchers at the University of Michigan Health System have found.
US researchers sound warning note over postponing fatherhood - new findings confirm male fertility declines with age
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A test to prove a woman has been raped
Stray Y chromosomes can confirm an allegation of rape A TEST that can prove a woman has been raped even if no sperm are found should be widely adopted, the first large-scale study suggests. After the trauma of rape, women who report it have to undergo a medical examination to look for sperm. But the test can fail, and as a result the woman`s claim to have been raped may not be believed. Now a French study has confirmed that a back-up test can often detect the male Y chromosome even if no sperm are found. The standard test, in which technicians use microscopes to look for sperm in vaginal, oral or
Low sperm count linked to organic solvents
Men repeatedly exposed to organic solvents are over twice as likely to have a low sperm count, reports a study in Occupational and Environmental Medicine. The higher the level of exposure the greater was the risk, with professional printers and painters and decorators most at risk, the study shows. The research team focused on over 1200 manual workers attending fertility clinics in Canada between 1972 and 1991. Over 600 of the men were patients at one clinic in Montreal; the remainder came from 10 clinics across the country who attended for treatment between 1984 to 1987. Each job was graded according to level of solvent exposure. Semen samples were analysed for volume and activity. After ta
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Low Sperm Count - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by ICON Health Publications (Author) In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading." Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. |
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Mountain bike aficionados suffer low sperm count, decreased fertility. (Use Bikes With Shock Absorbers).: An article from: Family Practice News by Patrick G.W. Norton (Author) This digital document is an article from Family Practice News, published by International Medical News Group on February 1, 2003. The length of the article is 447 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Mountain bike aficionados suffer low sperm count, decreased fertility. (Use Bikes With Shock Absorbers). Author: Patrick G.W. Norton Publication: Family Practice News (Magazine/Journal) Date: February 1, 2003 Publisher: International Medical News Group Volume: 33 Issue: 3 Page: 34(1) Distributed by Thomson... | |
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Natural Procreation Alternatives for Men With Low Sperm Counts in Childbearing Efforts by Howard Wayne, III Gabriel (Author) | |
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Fertil Aide for Men by Fairhaven Health FertilAid for Men provides: A Fertility-Enhancing Formula: promotes sperm motility, sperm quality, and sperm count. More L-Carnitine than other brands - a key nutrient in healthy sperm formation & increased motility. A rich source of powerful antioxidants to support reproductive health and reverse oxidative damage. A dynamic source of B-Vitamins and minerals like Zinc to promote male reproductive wellness. FertilAid Recommended Use: As a dietary supplement, take 3 capsules daily in divided doses with meals. Consult with physician if you have any pre-existing medical conditions before using. For Women's Formula: Discontinue use if you believe you are or may be pregnant. Do not take with clomid or fertility drugs. Benefits of herbal properties increase over time and may require as... |
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Strong&Steady (For Him) Formula - 200mg / 80 capsules by Health King Chinese medicine uses them to nourish the kidney and fortify the yang, maintain prostate and potency. |
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Sukraja for Male Potency - 60 Capsules (1 Month Supply) by India Herbs Sukraja naturally elevates testosterone and other hormone levels in your body to intensify libido and sperm production, stimulates liver functions and removes toxins from the blood to improve strength and stamina, nourishes the nerves to help your body adapt to stress better, exerts anabolic rejuvenative action to increase libido, rejuvenates prostate functions to increase semen volume and improve ejaculation, exhibits action similar to acetylcholine to improve sexual response, reduces sperm abnormalities, enhances gametogenic and androgenic functions of the testes to improve sperm quality and quantity, and stimulates thermogenic response to increase sperm motility and "warm the loins" as a precursor to sexual activity. The ingredients in Sukraja comprise a Proprietary Blend that goes to... |
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Spermarize Male Fertility 90 Tablets by Health King Balanceuticals Spermarize Male Fertility Supplement has been developed and used in China to increase male sperm count and the mobility of human sperm. |
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