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New lights on the pathogenic mechanisms of liver cirrhosis with ascites
September 24, 2008The pathogenic mechanisms implicated in the failure of intestinal barrier in cirrhosis have not been fully elucidated as yet and remains to be investigated.
A research article to be published on 28 June 20008, in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Shin and Dr. Lee investigated whether intestinal macromolecular permeability is altered in patients liver cirrhosis and its relationship with the serum TNF-α level and nitric oxide (NO) metabolite level in urine to clarify the role of intestinal macromolecular permeability, the serum TNF-α level and nitrite level in urine to the development of liver cirrhosis with ascites. The results suggest that increased intestinal macromolecular permeability and NO are probably of importance in the pathophysiology and progression of liver cirrhosis with ascites, and furthermore, increased intestinal permeability may be a contributory factor in the development of encephalopathy in liver cirrhosis.
In this study, there were no concomitant infections and a significantly higher TNF-α level in cirrhotic patients without ascites than healthy control subjects or patients with liver cirrhosis (LC) with ascites was seen; thus, there was a tendency for a negative correlation between the TNF-α level and Child-Pugh class in the advanced stage of LC. In advanced cirrhosis, hepatic damage and inflammation are reduced due to a decreased liver reserve and marked fibrosis, and consequently, ALT levels decrease. Additionally, diminished amounts of cytokine-producing cells such as hepatocytes and Kupffer cells may lead to a decrease of TNF-α production. In the current study, intestinal permeability index (%) and urinary nitrite excretion were significantly higher in patients with LC with ascites as compared to patients with LC without ascites or healthy control subjects, with a significant correlation.
World Journal of Gastroenterology
World Journal of Gastroenterology
Cirrhosis Current Events and Cirrhosis News RSSBariatric surgery may resolve liver disease
Obesity is a growing epidemic in the U.S. with a significant increase in prevalence from 15 percent to 32.9 percent from 1980 to 2004. Nonalcoholic fatty liver disease (NAFLD) is an emerging problem related to the obesity epidemic, becoming one of the most common causes of liver disease in the nation.
Mayo Clinic's new imaging technology accurately identifies a broad spectrum of liver disease
A new study shows that an imaging technology developed by Mayo Clinic researchers can identify liver fibrosis with high accuracy and help eliminate the need for liver biopsies. Liver fibrosis is a common condition that can lead to incurable cirrhosis if not treated in time.
If the diabetes has a direct carcinogenetic effect?
The association of DM2 with solid tumors, and particularly with HCC, has been long suspected and several studies have reported increased mortality rates for neoplastic diseases in patients with DM2.
Toxic Bile Damages the Liver
Researchers at the Heidelberg University Hospital have discovered a new genetic disease that can lead to severe liver damage. Because a protective component of the bile is missing, the liver cells are exposed to the toxic components of the bile, resulting in cirrhosis of liver, a transformation of liver cells into connective tissue with a gradual loss of liver function.
The risk factors of idiopathic pulmonary fibrosis in HCV patients
Hepatitis C virus (HCV) is one of the more common causes of chronic liver disease in world with a variety of extrahepatic complications such as essential mixed cryoglobulinemia, membranoproliferative glomerulonep hritis, autoimmune thyroiditis, sialadenitis, and cardiomyopathy.
Resveratrol prevents fat accumulation in livers of 'alcoholic' mice
The accumulation of fat in the liver as a result of chronic alcohol consumption could be prevented by consuming resveratrol, according to a new study with mice.
How to differentiate macro-regenerative nodules from hepato-carcinoma?
BA, the congenital absence or destruction of intra- or extra-hepatic biliary system, affects about 5 - 10/100 000 live births. End stage liver cirrhosis developed in some BA patients later in life.
Vitamin D deficiency common in patients with IBD, chronic liver disease
New research presented at the 73rd Annual Scientific Meeting of the American College of Gastroenterology in Orlando found patients with inflammatory bowel disease or chronic liver disease were at increased risk of developing Vitamin D deficiencies. Two separate studies highlight the importance of regular Vitamin D checkups in the evaluation of patients with certain digestive diseases.
Gene variant boosts risk of fatty liver disease, scientists discover
Researchers at UT Southwestern Medical Center have found that individuals who carry a specific form of the gene PNPLA3 have more fat in their livers and a greater risk of developing liver inflammation.
An effective strategy for inhibition of cirrhosis
In China, the incidence of liver cirrhosis is still high, although new therapeutic approaches have recently been proposed, there is no established therapy for liver fibrosis, and Authors investigated the prevention effects of Chinese Medicine Qianggan-Rongxian Soup on liver fibrosis induced by DMN in rat.
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