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How to differentiate abdominal tuberculosis from lymphomas?
September 24, 2008The incidence of tuberculosis is increasing. Lymphadenopathy is the most common manifestation of abdominal tuberculosis and may, in up to 55% of cases without other evidence of abdominal involvement, be easily confused with lymphomas involving abdominal lymph nodes. Clinical and radiologic differentiation between the two can be challenging. A comparison of CT findings in tuberculosis and lymphoma of the mesenteric lymph nodes has not been reported.
A research article to be published on 28 June 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Dong P from Weifang Medical University of China has determined that tuberculosis and non-Hodgkin's lymphomas (NHL) mainly affected the lymph nodes in the body and root of the SBM on CT images. Homogeneous enhanced lymph nodes in the body and root of SBM were more often in the NHL (P < 0.05). Homogeneous mixed with peripheral enhanced lymph nodes in the body of SBM were more often in mesenteric TL and TLM (P < 0.05). Peripheral enhanced lymph nodes in the root of SBM were more often in mesenteric TL and TLM (P < 0.01). "Sandwich sign" in the root of SBM was more often in NHL (P < 0.05). The result is helpful in differentiating between tuberculosis and untreated NHL involving the small bowel mesentery (SBM).
Tuberculosis demonstrates a variety of clinical and radiologic features depending on the organ site involved and has a known propensity for dissemination from its primary site. Lymphadenopathy is the most common manifestation of abdominal tuberculosis and may, in up to 55% of cases without other evidence of abdominal involvement, be easily confused with lymphomas involving abdominal lymph nodes. It is important to be familiar with the various radiologic features of tuberculosis and NHL involving the SBM to ensure accurate diagnosis.
The incidence of tuberculosis is increasing. Lymphadenopathy is the most common manifestation of abdominal tuberculosis. Currently, the comparison of CT findings in tuberculosis and lymphomas involving the SBM has not been published in english radiologic literature.
CT manifestations of tuberculosis and NHL mainly affected the lymph nodes in the body and root of the SBM. Homogeneous enhanced lymph nodes in the body and root of SBM were more often in the NHL (P < 0.05). Homogeneous mixed with peripheral enhanced lymph nodes in the body of SBM were more often in mesenteric TL and TLM (P < 0.05). Peripheral enhanced lymph nodes in the root of SBM were more often in mesenteric TL and TLM (P < 0.01). "Sandwich sign" in the root of SBM was more often in NHL (P < 0.05).
In the view of the authors, the CT can show the specific enhancement patterns of lymphadenopathy, sandwich sign and anatomic lymph nodes distribution in tuberculosis and untreated NHL involving the SBM.
This article describes the difference between tuberculosis and NHL involved the SBM, and CT is helpful to the diagnosis and differential diagnosis of the tuberculosis and NHL involving the SBM.
Further research should compare the CT findings of mesenteric tuberculosis with metastatic malignancy and other entities which involved the SBM.
World Journal of Gastroenterology
The incidence of tuberculosis is increasing. Lymphadenopathy is the most common manifestation of abdominal tuberculosis. Currently, the comparison of CT findings in tuberculosis and lymphomas involving the SBM has not been published in english radiologic literature.
CT manifestations of tuberculosis and NHL mainly affected the lymph nodes in the body and root of the SBM. Homogeneous enhanced lymph nodes in the body and root of SBM were more often in the NHL (P < 0.05). Homogeneous mixed with peripheral enhanced lymph nodes in the body of SBM were more often in mesenteric TL and TLM (P < 0.05). Peripheral enhanced lymph nodes in the root of SBM were more often in mesenteric TL and TLM (P < 0.01). "Sandwich sign" in the root of SBM was more often in NHL (P < 0.05).
In the view of the authors, the CT can show the specific enhancement patterns of lymphadenopathy, sandwich sign and anatomic lymph nodes distribution in tuberculosis and untreated NHL involving the SBM.
This article describes the difference between tuberculosis and NHL involved the SBM, and CT is helpful to the diagnosis and differential diagnosis of the tuberculosis and NHL involving the SBM.
Further research should compare the CT findings of mesenteric tuberculosis with metastatic malignancy and other entities which involved the SBM.
World Journal of Gastroenterology
Lymph Node Current Events and Lymph Node News RSSStudy of concurrent radiotherapy, chemotherapy shows promise in small cell lung cancer
Treating limited stage small cell lung cancer(LSCL) with a combination of accelerated high-dose radiotherapy and chemotherapy has shown encouraging results.
Although more older women receive breast-conserving therapy, gaps in treatment exist
According to a new study published in the October issue of the Journal of the American College of Surgeons, although breast-conserving surgery (BCS), commonly known as lumpectomy, is increasingly being used to treat older women with nonmetastatic invasive breast cancer, there are still significant socioeconomic and geographic disparities in the use of this type of therapy.
Study finds no relationship between PCR rate and race in women with breast cancer
Locally advanced breast cancer patients who received the same class of neoadjuvant chemotherapy were found to have no evidence of disease at the time of their surgery, or achieved pathological complete response, at the same rate regardless of race, according to researchers at The University of Texas M. D. Anderson Cancer Center.
Ultrasound can predict tumor burden and survival in melanoma patients
Researchers have shown for the first time that patterns of ultrasound signals can be used to identify whether or not cancer has started to spread in melanoma patients, and to what extent. The discovery enables doctors to decide on how much surgery, if any, is required and to predict the patient's probable survival.
Green tea extract shows promise in leukemia trials
Mayo Clinic researchers are reporting positive results in early leukemia clinical trials using the chemical epigallocatechin gallate (EGCG), an active ingredient in green tea.
What is the function of lymph nodes?
If we imagine our immune system to be a police force for our bodies, then previous work has suggested that the Lymph nodes would be the best candidate structures within the body to act as police stations - the regions in which the immune response is organised.
Computer simulation captures immune response to flu
Researchers have successfully tested first the first time a computer simulation of major portions of the body's immune reaction to influenza type A, with implications for treatment design and preparation ahead of future pandemics, according to work accepted for publication, and posted online, by the Journal of Virology.
Study points toward relationship between cancer stem cells and prognosis in primary breast cancer
Breast cancer patients who received chemotherapy prior to surgery had heightened levels of cancer-initiating stem cells in their bone marrow, and the level of such cells correlated to a tumor's lymph node involvement, according to research from The University of Texas M. D. Anderson Cancer Center.
Study reveals current multi-component vaccines may need reworking
Current strategies for designing vaccines against HIV and cancers, for instance, may enable some components in multi-component vaccines to cancel the effect of others on the immune system, eliminating their ability to provide protection, according to an article to be published shortly in the Proceedings of the National Academy of Sciences (PNAS).
New technique may help detect potential breast cancer spread
A new phase III clinical trial of early stage breast cancer patients has shown that a molecule designed to home in on nearby lymph nodes is just as accurate as current techniques, but faster, more specific and easier to use.
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