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What is the best strategy for treating Helicobacter pylori?
September 24, 2008The most popular treatment for H pylori is triple therapy but resistance to Clarithromycin is reducing its effectiveness. Courses using four drugs have been known to be more successful but are used less popular because of their side-effects. While, what is the best way for treating H pylori-related diseases.
A research article to be published on 28 June 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Mr Siok Ching from United Kingdom compared a lansoprazole-based triple versus quadruple therapy for H pylori eradication with emphasis on side effect profile, patient compliance and eradication rate at a rural district general hospital in Wales, United Kingdom.
Overall the treatment of H Pylori using both three drugs and four drugs are still highly effective in rural North Wales (92%), however, almost all (97%) of the patients who managed to complete the course of four tablets got rid of the infection.
Authors feel that treatments with four drugs remain the best option for white Caucasians in rural UK. Patients need educating about the side effects of the drugs and the reasons for treatment so that they can reap the full benefits.
They concluded that one-week triple and quadruple therapies have similar intention-to-treat eradication rates. Certain side effects are more common with quadruple therapy, which can compromise patient compliance. Patient education or modifications to the regimen are alternative options to improve compliance of the quadruple regimen.
The side effects may be reduced by replacing metronidazole with amoxycillin but patients should be better educated about the side effects in order to improve compliance and cure rates.
World Journal of Gastroenterology
Authors feel that treatments with four drugs remain the best option for white Caucasians in rural UK. Patients need educating about the side effects of the drugs and the reasons for treatment so that they can reap the full benefits.
They concluded that one-week triple and quadruple therapies have similar intention-to-treat eradication rates. Certain side effects are more common with quadruple therapy, which can compromise patient compliance. Patient education or modifications to the regimen are alternative options to improve compliance of the quadruple regimen.
The side effects may be reduced by replacing metronidazole with amoxycillin but patients should be better educated about the side effects in order to improve compliance and cure rates.
World Journal of Gastroenterology
H Pylori Current Events and H Pylori News RSSStomach ulcer bug causes bad breath
Bacteria that cause stomach ulcers and cancer could also be giving us bad breath, according to research published in the December issue of the Journal of Medical Microbiology.
Researchers describe how chronic inflammation can lead to stomach cancer
A multi-center research team, led by Columbia University Medical Center, has uncovered a major contributor to the cause of stomach cancer - the second leading cause of cancer-related mortality in the world.
H. Pylori bacteria may help prevent some esophageal cancers
Some bacteria may help protect against the development of a type of esophageal cancer, known as adenocarcinoma, according to a new review of the medical literature. These bacteria, which are called Helicobacter pylori, live in the stomachs of humans.
Which is more accurate, serology test or C14-urea breath test?
Serology and C14-UBT are the most commonly used non-invasive tests of H. pylori infection. The diagnostic characteristics of the tests depend also on the prevalence of H. pylori infection in the population tested.
Going from ulcers to cancer
Researchers have uncovered a big clue as to why some of the bacteria that cause stomach ulcers pose a greater risk for serious problems like stomach cancer than others; it turns out these bacteria can exploit the surrounding stomach cells to protect them from the immune system.
ASGE issues guidelines on the role of endoscopy in the bariatric surgery patient
The American Society for Gastrointestinal Endoscopy (ASGE) has issued guidelines on the role of endoscopy in the bariatric surgery patient.
Early treatment of stomach infection may prevent cancer
Based on research using a new mouse model of gastritis and stomach cancer, researchers from the Massachusetts Institute of Technology (MIT) say that prompt treatment of Helicobacter pylori (H. pylori) infections reverses damage to the lining of the stomach that can lead to cancer.
Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors
This study determined the efficiency of a gastric juice PCR test for the detection of H. pylori infection in patients receiving PPI therapy and compared it with histology and gastric biopsy PCR.
How is H pylori adhesion to gastric cells associated with MUC1 mucin VNTR size?
The Gram negative bacterium H pylori is involved in the pathogenesis of several gastrointestinal diseases, ultimately leading to gastric carcinoma. Adhesion of the bacteria to the gastric mucosa is an essential step for colonization and infection.
What are the essential characteristics of serum PG in Chinese?
Pepsinogen (PG) is a precursor for pepsin, a digestive enzyme specifically produced in the gastric mucosa. Human PG can be classified into two different biochemical and immunological properties, PGI and PGII.
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