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The natural history of 'healthy-HCV carriers'
September 24, 2008A normal liver is observed in about 10% of HCV infected patients and the natural history of theses so-called "healthy-HCV carriers" is not fully defined.
An article published on 28 June 2008, in the World Journal of Gastroenterology addresses the question of the evolution of theses "healthy-HCV carriers". In this research lead by Dr Sobesky R and his colleagues from the Unit of Hepatology, Hospital Cochin, Paris, the authors try to determine factors associated with fibrosis progression in HCV-infected patients without significant initial pathological lesions.
After a median interval of 4 years, there is no fibrosis progression in 66% of patients. By multivariate analysis, fibrosis progression was associated with elevated transaminases, body mass index upper to 25, and the time interval between 2 biopsies.
This study confirms the concept that the natural history of chronic hepatitis in this group of subjects is characterized by a very slow or no fibrosis progression. We can differentiate in these "asymptomatic carriers" a sub-group of patients with elevated transaminases and overweight, which is exposed to fibrosis progression. Moreover, theses patients with a higher risk of liver fibrosis progression should receive an antiviral therapy. HCV-infected patients with overweight should be informed of the risk of liver fibrosis progression and the need of dietetic councils.
World Journal of Gastroenterology
This study confirms the concept that the natural history of chronic hepatitis in this group of subjects is characterized by a very slow or no fibrosis progression. We can differentiate in these "asymptomatic carriers" a sub-group of patients with elevated transaminases and overweight, which is exposed to fibrosis progression. Moreover, theses patients with a higher risk of liver fibrosis progression should receive an antiviral therapy. HCV-infected patients with overweight should be informed of the risk of liver fibrosis progression and the need of dietetic councils.
World Journal of Gastroenterology
Is endotoxin receptor CD14 rs2569190/C-159T gene correlated with chronic hepatitis C?
It is still unknown why the natural history of chronic disease caused by hepatitis C virus (HCV), which currently infects 3% of the world's population, varies from mild in some patients to rapidly progressing in others.
FibroTest attributes to generate decision trees in hepatitis C
In recent years the use of non-invasive biomarkers to assess liver fibrosis has become widely accepted.
Most chronic hepatitis C sufferers will develop cirrhosis in later life
Nearly 80 percent of chronic hepatitis C sufferers who have the disease for several decades will develop cirrhosis or end-stage liver disease later in life.
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