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What is the role of interleukin-10 in ischemia-reperfusion injury?
September 26, 2008I/R injury of the small intestine is consequently a critical problem that is important. DHP-PMX therapy can remove circulating endotoxins and reduce various cytokines, even in patients with high levels of plasma cytokines. DHP-PMX therapy has also been attempted for severe sepsis secondary to intra-abdominal infection, acute lung injury, and acute respiratory distress syndrome caused by sepsis, and its effectiveness has been reported.
A research article to be published on September 21, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Izumi Takeyoshi from Gunma University Graduate School of Medicine in Japan hypothesized that DHP-PMX therapy could reduce I/R injury and demonstrated the usefulness of this therapy on pulmonary warm I/R injury in a canine model.
The Authors suggested that the absorption of anandamide by PMX might abolish the diverse negative effects of anandamide such as hypotension, immunosuppression, and cytotoxicity. Taking these results into consideration, the possibility exists that treatment with PMX not only removes endotoxin, but also reduces inflammatory reactions through the inhibition of various inflammatory cascades and has an effective role on I/R injury.
They demonstrated that direct hemoperfusion with a polymyxin B-immobilized cartridge reduced the reperfusion injury in small intestine. DHP-PMX therapy reduced warm I/R injury of the small intestine, and IL-10 may play a role to inhibit I/R injury with DHP-PMX therapy. This study was nicely designed and performed.
World Journal of Gastroenterology
They demonstrated that direct hemoperfusion with a polymyxin B-immobilized cartridge reduced the reperfusion injury in small intestine. DHP-PMX therapy reduced warm I/R injury of the small intestine, and IL-10 may play a role to inhibit I/R injury with DHP-PMX therapy. This study was nicely designed and performed.
World Journal of Gastroenterology
Why could prednisolone suppress the hepatic ischemia-reperfusion injury?
Hepatic ischemia-reperfusion injury is a serious complication but unavoidable problem in liver surgery including liver transplantation and hepatic resection.
Preventing spinal cord injury during aortic surgery
Surgery to repair aortic aneurysms often comes with a high price: neurological deficits, but new research points to a possible defense against spinal cord injury during aortic surgery.
Nature and the Nature research journals press release
[1] Leptin regulates bone remodelling
More Ischemia-reperfusion Injury Current Events and Ischemia-reperfusion Injury News Articles
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The effects of carbenoxolone, a semisynthetic derivative of glycyrrhizinic acid, on peripheral and central ischemia-reperfusion injuries in the skeletal ... Journal of Phytotherapy & Phytopharmacology by H. Hosseinzadeh (Author), M. Nassiri Asl (Author), S. Parvardeh (Author) This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Thomson Gale on September 1, 2005. The length of the article is 4390 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: The effects of carbenoxolone, a semisynthetic derivative of glycyrrhizinic acid, on peripheral and central ischemia-reperfusion injuries in the skeletal muscle and hippocampus of rats. Author: H. Hosseinzadeh Publication: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Magazine/Journal) Date: September... | |
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Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus.: ... Journal of Phytotherapy & Phytopharmacology by Hossein Hosseinzadeh (Author), Siavash Parvardeh (Author), Marjan Nassiri Asl (Author), Hamid R. Sadeghnia (Author), Toktam Ziaee (Author) This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Thomson Gale on September 1, 2007. The length of the article is 4649 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Author: Hossein Hosseinzadeh Publication: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Magazine/Journal) Date: September 1, 2007 Publisher: Thomson... | |
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Renal Ischemia / Reperfusion Injury in Diabetes (Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1131) by Jan Melin (Author) | |
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Discovery of N-Hydroxyguanidines As Novel Electron Acceptors of Xanthine Oxidase: Potential New Drugs for Treatment of Ischemia and Reperfusion Injury ... from the Faculty of Pharmacy, 217) by Maija Dambrova (Author) | |
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Ischemia-Reperfusion Injury in Cardiac Surgery (Medical Intelligence Unit) by Friedhelm Beyersdorf (Author) During the last decades, major improvements have been developed in reducing both ischemic and reperfusion injury associated with cardiac surgery and therefore, improving the quality of the operation. This book summarizes the newest developments in this field with background information on how these techniques have been established. In addition, it reviews patient protection during both routine cardiac procedures and prolonged, technically demanding operations. |
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Ischemia: Reperfusion Injury of Skeletal Muscle (Medical Intelligence Unit) by Gary A. Fantini (Editor) This publication represents an up-to-date summary of the current understanding of reoxygenation injury in skeletal muscle and outlines future directions of those who will lead the way in this field. Skeletal muscle is generally more tolerant of ischemia reperfusion injury than other organ systems such as brain, heart, kidney, liver and bowel. Current knowledge regarding the pathophysiology of such injury has attracted correspondingly less attention and has been relatively slow to accumulate. This monograph brings together acknowledged leaders who have focused their research efforts on identifying mechanisms of reoxygenation injury in skeletal muscle; the virtual plethora of pathways and cytokines involved in the mediation of cellular injury is attested to by the number and diversity of... | |
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Inflammation in a Murine Model of Lung Ischemia Reperfusion Injury (Acta Biomedica Lovaniensia) by Nele Geudens (Author) | |
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Major Limb Replantation and Postischemia Syndrome: Investigation of Acute Ischemia-Induced Myopathy and Reperfusion Injury by Hans-Ulrich Steinau (Author) Posttraumatic stump formation and replantation of the severed limb are both reconstructive plastic operations which may lead to the improvement or destruction of a patient's lifestyle. For the primary attending surgeon, the decision whether to undertake such an operation depends on the patient's clinical condition, the operational circumstances, the psychological and social aspects and, last but not least, on the surgeon's own abilities. This monograph is designed as a synopsis of the great number of patho-physiological parameters and surgical and rehabilitational aspects which must be considered in the analysis of complications in major limb replantation. In addition, basic information about the key role of ischemic myopathy and microangiopathy is supplied to encourage further... | |
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Ischemia and Reperfusion of Various Organs: Injury Mechanisms, Methods of Prevention and Treatment by M. V. Bilenko (Author) Throughout the world, cardiovascular diseases associated with ischemic and reperfusion organ injuries are among the main factors of human mortality. Hence, the analysis of mechanisms responsible for these injuries and the development of approaches to their prevention and treatment present a pressing problem for specialists in biology and medicine. This book is based on firsthand experience gained by the author and her research team during many years of experimental studies, supported by the analysis of abundant literature published between 1970 and 1999. It deals with the comparative assessment of ischemic and reperfusion injuries and their mechanisms in vitally important organs differing in their sensitivity to oxygen deficiency, metabolic activity, and provision with... |
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