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MU scientists go green with gold, distribute environmentally friendly nanoparticles
September 29, 2008
Mizzou scientist named as one of the 25 most influential people in radiology COLUMBIA, Mo. -- Gold nanoparticles are everywhere. They are used in cancer treatments, automobile sensors, cell phones, blood sugar monitors and hydrogen gas production. However, until recently, scientists couldn't create the nanoparticles without producing synthetic chemicals that had negative impacts on the environment. A new method, created by a University of Missouri research team, not only eliminates any negative environmental impact, but also has resulted in national and international recognition for the lead scientist. The research was published recently in the journal Small.
"I have always believed that nature is smarter and stronger than humankind," said Kattesh Katti, professor of radiology and physics in MU's School of Medicine and College of Arts and Science, senior research scientist at the MU Research Reactor, and director of the MU Cancer Nanotechnology Platform. "This new procedure to create nanoparticles is wonderfully simple, yet it will help create very complex components. There is so much to learn from energy generation, chemical and photochemical reactions of plants."
Katti, who was recently recognized by rt Image magazine as one of the 25 most influential people in radiology, and his research team have formed Greennano Company, a company that is in the beginning stages of producing environmentally friendly gold nanoparticles. The company will focus on the development, commercialization and worldwide supply of gold nanoparticles for medical and technological applications. Katti believes that because of this new process to produce the nanoparticles, researchers are developing other ways to use them.
The MU research team, which was led by Katti, Raghuraman Kannan and Kavita Katti, found that by submersing gold salts in water and then adding soybeans, gold nanoparticles were generated. The water pulls a phytochemical out of the soybean that is effective in reducing the gold to nanoparticles. A second phytochemical from the soybean, also pulled out by the water, interacts with the nanoparticles to stabilize them and keep them from fusing with the particles nearby. This process creates nanoparticles that are uniform in size in a 100-percent green process. No toxic waste is generated.
"I'm very proud to be one among the list of '25 Most Influential Scientists' in the world, especially in the company of all time greats and former awardees including: Elias Zerhouni, director of National Institutes of Health (2003); Henry N. Wagner Jr., recognized as the Father of Nuclear Medicine (2004); Henry D. Royal, Peter S. Conti, past presidents of the Society of Nuclear Medicine; and Barry B. Goldberg, pioneer of ultrasound (2007)," Katti said. "This recognition is a tremendous honor and brings a large amount of prestige to our research group, the Departments of Radiology and Physics, the MU Research Reactor Center and the overall research and education enterprise of our University."
"They all had one thing in common; they possessed the integrity, drive and passion deserving of the title 'Most Influential,'" said Heather B. Koitzsch, publisher of rt Image. "In this year's list, you'll read about people who are changing the face of medicine, associations that are advocating for better patient care, and researchers whose efforts are uncovering new diagnostic techniques. Whether through speaking, campaigning, researching, creating or leading, someone who is "Most Influential" is committed to making things happen in radiology."
University of Missouri-Columbia
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Synthesis and characterization of gold nanoparticles by tryptophane.: An article from: American Journal of Applied Sciences
by Azim Akbarzadeh (Author), Davood Zare (Author), Ali Farhangi (Author), Mohammad Reza Mehrabi (Author), Dariush Norouzian (Author), Shahram Tangestaninejad (Author), Majid Moghadam (Author), Nasim Bararpour (Author)
This digital document is an article from American Journal of Applied Sciences, published by Science Publications on April 1, 2009. The length of the article is 2558 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.
From the author: Key words: Gold nanoparticles, chemical reduction, L-tryptophane, stability
Citation Details Title: Synthesis and characterization of gold nanoparticles by tryptophane. Author: Azim Akbarzadeh Publication: American Journal of Applied Sciences (Magazine/Journal) Date: April 1, 2009 Publisher: Science Publications Volume: 6 Issue: 4 Page: 691(5)
Distributed by Gale, a part of...
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![Self-assembling gold nanoparticles on thiol-functionalized poly(styrene-co-acrylic acid) nanospheres for fabrication of a mediatorless biosensor [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg)
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Self-assembling gold nanoparticles on thiol-functionalized poly(styrene-co-acrylic acid) nanospheres for fabrication of a mediatorless biosensor [An article from: Analytica Chimica Acta]
by S. Xu (Author), G. Tu (Author), B. Peng (Author), X. Han (Author)
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description: A novel strategy to construct a sensitive mediatorless sensor of H"2O"2 was described. At first, a cleaned gold electrode was immersed in thiol-functionalized poly(styrene-co-acrylic acid) (St-co-AA) nanosphere latex prepared by emulsifier-free emulsion polymerization St with AA and function with dithioglycol to assemble the nanospheres, then gold nanoparticles were chemisorbed onto the thiol groups and formed monolayers on the surface of poly(St-co-AA) nanospheres. Finally, horseradish peroxidase (HRP) was...
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![Gold nanoparticle arrays directly grown on nanostructured indium tin oxide electrodes: Characterization and electroanalytical application [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg)
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Gold nanoparticle arrays directly grown on nanostructured indium tin oxide electrodes: Characterization and electroanalytical application [An article from: Analytica Chimica Acta]
by J. Zhang (Author), M. Oyama (Author)
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description: This work describes an improved seed-mediated growth approach for the direct attachment and growth of mono-dispersed gold nanoparticles on nanostructured indium tin oxide (ITO) surfaces. It was demonstrated that, when the seeding procedure of our previously reported seed-mediated growth process on an ITO surface was modified, the density of gold nanospheres directly grown on the surface could be highly improved, while the emergence of nanorods was restrained. By field emission scanning electron microscopy...
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![Gold nanoparticle-enhanced surface plasmon resonance measurement with a highly sensitive quantification for human tissue inhibitor of metalloproteinases-2 [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg)
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Gold nanoparticle-enhanced surface plasmon resonance measurement with a highly sensitive quantification for human tissue inhibitor of metalloproteinases-2 [An article from: Analytica Chimica Acta]
by U. Pieper-Furst (Author), W.F.M. Stocklein (Author), A. Warsinke (Author)
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description: Two different methods for the quantification of human tissue inhibitor of metalloproteinases-2 (TIMP-2) were developed using surface plasmon resonance (SPR) and gold nanoparticles for signal enhancement. The first method, a competitive assay, used TIMP-2 immobilized to the sensor surface and the inactive form of matrix metalloproteinase-2 (proMMP-2) (EC 3.4.24.24) adsorbed to gold nanoparticles. The sensor signals resulting from the interaction of MMP-2-gold nanoparticles with immobilized TIMP-2 were inversely...
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![Fabrication of layer-by-layer deposited multilayer films containing DNA and gold nanoparticle for norepinephrine biosensor [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg)
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Fabrication of layer-by-layer deposited multilayer films containing DNA and gold nanoparticle for norepinephrine biosensor [An article from: Analytica Chimica Acta]
by L.P. Lu (Author), S.Q. Wang (Author), X.Q. Lin (Author)
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description: The present work describes the preparation and characterization of an electrodeposited DNA membrane doped with gold nanoparticles for the design of biosensors. The gold nanoparticles were deposited on the surface of DNA layer to build a hybrid device of nanoscale electrode array. The gold nanoparticles-doped DNA composite electrode was characterized by atomic force microscopy, scanning electron microscope, and electrochemistry involving electrochemical impedance spectroscopy. This electrode was successfully...
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Fabrication of 2D- and 3D-nanostructures made of gold nanoparticles and the electrical properties. (Industry Insight).: An article from: Nanoparticle News
by Takayuki Takahagi (Author), Shujuan Huang (Author)
This digital document is an article from Nanoparticle News, published by Business Communications Company, Inc. on August 1, 2002. The length of the article is 1139 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details Title: Fabrication of 2D- and 3D-nanostructures made of gold nanoparticles and the electrical properties. (Industry Insight). Author: Takayuki Takahagi Publication: Nanoparticle News (Magazine/Journal) Date: August 1, 2002 Publisher: Business Communications Company, Inc. Volume: 5 Issue: 7 Page: 8(2)
Distributed by Thomson...
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![Femtomolar immunoassay based on coupling gold nanoparticle enlargement with square wave stripping voltammetry [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg)
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Femtomolar immunoassay based on coupling gold nanoparticle enlargement with square wave stripping voltammetry [An article from: Analytica Chimica Acta]
by K.T. Liao (Author), H.J. Huang (Author)
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description: The enhancement in sensitivity for an electrochemical immunoassay by the autocatalytic deposition of Au^3^+ onto gold nanoparticles has been studied. By coupling the autocatalytic deposition with square-wave stripping voltammetry, enlarged gold nanoparticles labeled on goat anti-rabbit immunoglobulin G (GaRIgG-Au) and, thus, the rabbit immunoglobulin G (RIgG) analyte could be determined quantitatively. A variety of variables, such as concentration of AuCl"4^-, the reducing agent used, the duration of...
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Development of gold-silica composite nanoparticle substrates for perchlorate detection by surface-enhanced Raman spectroscopy [An article from: Analytica Chimica Acta]
by W. Wang (Author), C. Ruan (Author), B. Gu (Author)
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description: Surface-enhanced Raman spectroscopy (SERS) holds promise for rapid, in situ detection of perchlorate (ClO"4^-) in the environment if sensitive and reproducible SERS substrates can be developed. In this study, new, functionalized gold-silica (Au-SiO"2) composite nanoparticles were synthesized and used as SERS substrates for ClO"4^- detection. These nanoparticles were composed of a silica core with Au nanoparticles grafted onto the SiO"2 spheres by in situ chemical reduction of AuCl"4^- or physisorption of Au...
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![Surface-enhanced Raman scattering for perchlorate detection using cystamine-modified gold nanoparticles [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg)
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Surface-enhanced Raman scattering for perchlorate detection using cystamine-modified gold nanoparticles [An article from: Analytica Chimica Acta]
by C. Ruan (Author), W. Wang (Author), B. Gu (Author)
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description: Perchlorate (ClO"4^-) has recently emerged as a widespread environmental contaminant found in groundwater and surface water, and there is a great need for rapid detection and monitoring of this contaminant. This study presents a new technique using cystamine-modified gold nanoparticles as a substrate for surface-enhanced Raman scattering (SERS) detection of perchlorate at low concentrations. A detection limit of 5x10^-^6M (0.5mg/L) has been achieved using this method without sample preconcentration. This result...
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![A novel immunoassay based on the dissociation of immunocomplex and fluorescence quenching by gold nanoparticles [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg)
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A novel immunoassay based on the dissociation of immunocomplex and fluorescence quenching by gold nanoparticles [An article from: Analytica Chimica Acta]
by Z. Peng (Author), Z. Chen (Author), J. Jiang (Author), X. Zhang (Author), G. Shen (Author), Yu (Author)
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description: This study reports a novel, simple and sensitive immunoassay using fluorescence quenching caused by gold nanoparticles coated with antibody. The method is based on a non-competitive heterogeneous immunoassay of human IgG conducted by the typical procedure of sandwich immunocomplex formation. Goat anti-human IgG was first adsorbed on polystyrene microwells, and human IgG analyte was captured by the primary antibody and then sandwiched by antibody labeled with gold nanoparticles. The sandwich-type immunocomplex...
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