Hepatitis B exposure may increase risk for pancreatic cancerSeptember 30, 2008HOUSTON - In a first-of-its-kind finding, researchers at The University of Texas M. D. Anderson Cancer Center have discovered that exposure to the hepatitis B virus (HBV) may increase the risk of pancreatic cancer. The study, published in the Oct. 1 edition of the Journal of Clinical Oncology, also suggests that patients with this lethal form of cancer treated with chemotherapy may face danger of reactivation of their HBV. Pancreatic cancer is diagnosed in 37,000 people in the United States each year, and more than 34,000 people die of the disease annually, according to the American Cancer Society. It is often diagnosed in the late stages and is especially perplexing because few risk factors are known.
"If this study is validated, it will give us more information about the risk factors of pancreatic cancer and possibly even help prevent it in some cases," said lead author Manal Hassan, M.D., Ph.D., assistant professor in M. D. Anderson's Department of Gastrointestinal Medical Oncology. HBV and hepatitis C virus (HCV) are major global health problems, affecting about 2 percent of the population worldwide. In the United States 1.25 million people have chronic HBV, while 3.2 million have chronic HCV. These systemic viruses can harm the body in a variety of ways, including traveling through the bloodstream and damaging tissues throughout the body. The word "hepatitis" means "inflammation of the liver," and previous research has shown HBV and HCV are major causes of liver cancer. Little is known about their roles in other cancers. However, the proximity of the liver to the pancreas and the fact the pancreas and liver share common blood vessels and ducts make the pancreas a potential target for hepatitis viruses. While this is the first study to examine whether exposure to HBV and HCV increases risk for pancreatic cancer, other research has indicated chronic HBV infection may impair pancreatic function and that HBV may replicate in the pancreas, Hassan said. In this study, which began in 2000, 476 M. D. Anderson patients with early pancreatic cancer were identified. Additionally, 879 people without pancreatic cancer were matched with the patients by age, gender and race. All participants were interviewed for demographic and risk factors information. Then researchers tested the blood of all participants for the presence of HCV and HBV antibodies, which indicate past exposure to HCV and HBV. The prevalence of past exposure to HBV was significantly higher (7.6 percent) in people with pancreatic cancer than in healthy people (3.2 percent). However, exposure to HCV was not significantly different in the two groups. In addition, the study confirmed previously reported risk associations of cigarette smoking, history of diabetes and a family history of pancreatic cancer. People exposed to HBV may develop occult, or hidden, HBV infection. In these cases, the M. D. Anderson researchers say, there is a potential for reactivation of HBV during chemotherapy, the most common treatment for pancreatic cancer. Chemotherapy may suppress the immune system, leading to viral replication of the HBV, the researchers explained. "If these results are validated, physicians might want to test pancreatic cancer patients for HBV before administering chemotherapy," said senior author James Abbruzzese, M.D., professor and chair of M. D. Anderson's Department of Gastrointestinal Medical Oncology and associate medical director of the Gastrointestinal Center. "Reactivation of HBV could potentially cause liver damage and even liver failure." Researchers stress these early results need to be studied further and plan to collaborate with other institutions to compare results among other populations and people who are actually infected with the virus. If they are confirmed, these results may offer new insight into pancreatic cancer, possibly even preventing some cases in the future. "We are working hard to try to understand the factors that are risks to developing pancreatic cancer, particularly modifiable risks," Abbruzzese said. "If these results are confirmed, people at risk might be able to help prevent pancreatic cancer by getting an HBV vaccine." University of Texas M. D. Anderson Cancer Center Science News and Science Current Events Tag Cloud This tag cloud is a visual representation of term frequencies of random science news topics with common terms grouped together and emphasized by their display size. Sleep Disorder Relationships Spinal Cord Loneliness Fertility Drug Resistance Food Safety DNA Smokers Irrigation Childhood Cancer Happiness Ecosystem Glaciers Coral Honey Bee Soybean Human Genome Idiopathic Pulmonary Fibrosis Tsunami Embryonic Development Quantum Computing Genome Sequencing Cosmic Rays Kidney Transplant
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Related Pancreatic Cancer Current Events and Pancreatic Cancer News Articles Being overweight, obese during early adulthood associated with greater risk of pancreatic cancer Young adults who are overweight or obese have an increased risk of pancreatic cancer, and being obese at an older age is associated with a lower overall survival rate for patients with pancreatic cancer. M. D. Anderson study finds strong relationship between high body mass index, pancreatic cancer In reviewing the weight history of pancreatic cancer patients across their life spans, researchers at The University of Texas M. D. Anderson Cancer Center have determined that a high body mass index in early adulthood may play a significant role in an individual developing the disease at an earlier age. Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells Pancreatic cancer is a devastating disease with poor prognosis. This warrants the development of novel therapies including gene therapy. Colon Cancer Screening Technique Shows Continued Promise in New Study Recent clinical trials show that a new colon cancer screening technique created by Northwestern University researchers has a high enough sensitivity that it could potentially be as or more successful than a colonoscopy in screening for colon cancer. Mayo Clinic finds new pathology tests double sensitivity to detect bile duct and pancreatic cancers Pancreatic cancer and bile duct cancer are difficult to diagnose and often fatal because they are discovered in the advanced stages of the disease. miR-196a promotes the metastases of tumors MicroRNAs are small RNA molecules of 20-25 nucleotides length, regulating gene expression by inhibition of transcription or translation of proteins. Popular diabetes treatment could trigger pancreatitis, pancreatic cancer A drug widely used to treat Type 2 diabetes may have unintended effects on the pancreas that could lead to a form of low-grade pancreatitis in some patients and a greater risk of pancreatic cancer in long-term users, UCLA researchers have found. Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the efficacy of the Opioid Growth Factor (OGF, [Met5]-enkephalin), a clinically important antitumor agent, is dependent on nucleocytoplasmic translocation and reliant on the integrity of nuclear localization signals in the OGF receptor (OGFr). Newly discovered epidermal growth factor receptor active in human pancreatic cancers Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the difficulties of early detection and the lack of effective therapies: Johns Hopkins University pathologist Akhilesh Pandey has identified an epidermal growth factor receptor aberrantly active in approximately a third of the 250 human pancreatic cancers studied. New drug achieves pancreatic cancer tumor remission and prevents recurrence Pancreatic cancer remains one of the deadliest cancers, but researchers may have found a combination therapy to reduce cancer stem cells and stop pancreatic cancer growth. Results will be presented at the American Association for Cancer Research 100th Annual Meeting 2009. More Pancreatic Cancer Current Events and Pancreatic Cancer News Articles |
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