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During exercise, the human brain shifts into high gear on 'alternative energy'
October 01, 2008New article in the FASEB Journal shows that the brain uses lactate not glucose as fuel
Alternative energy is all the rage in major media headlines, but for the human brain, this is old news. According to a study by researchers from Denmark and The Netherlands published in the October 2008 print issue of The FASEB Journal, the brain, just like muscles, works harder during strenuous exercise and is fueled by lactate, rather than glucose. Not only does this finding help explain why the brain is able to work properly when the body's demands for fuel and oxygen are highest, but it goes a step further to show that the brain actually shifts into a higher gear in terms of activity. This opens doors to entirely new areas of brain research related to understanding lactate's specific neurological effects.
"Now that we know the brain can run on lactate, so to speak, future studies should show us when to use lactate as part of a treatment," said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal. "From an evolutionary perspective, the result of this study is a no-brainer. Imagine what could have or did happen to all of the organisms that lost their wits along with their glucose when running from predators. They were obviously a light snack for the animals able to use lactate."
To reach their conclusion, the researchers looked at research that compared the blood running to and from the heads of volunteers undergoing strenuous exercise. They found that the blood on its way to the brain contained considerably more lactate than blood flowing from the brain. Further investigation showed that the brain was not storing the lactate which had come from the muscles during exercise, but rather using it as fuel. In fact, the brain helped to clear lactate from the circulation, thereby leaving glucose to the muscles that need it for the hard work they were performing.
Federation of American Societies for Experimental Biology
To reach their conclusion, the researchers looked at research that compared the blood running to and from the heads of volunteers undergoing strenuous exercise. They found that the blood on its way to the brain contained considerably more lactate than blood flowing from the brain. Further investigation showed that the brain was not storing the lactate which had come from the muscles during exercise, but rather using it as fuel. In fact, the brain helped to clear lactate from the circulation, thereby leaving glucose to the muscles that need it for the hard work they were performing.
Federation of American Societies for Experimental Biology
Exercise Current Events and Exercise News RSSNew tool for helping pediatric heart surgery
A team of researchers at the University of California, San Diego and Stanford University has developed a way to simulate blood flow on the computer to optimize surgical designs.
Researchers begin to decipher metabolism of sexual assault drug
It's a naturally occurring brain chemical with an unwieldy name: 4-hydroxybutyrate (4-HB). Taken by mouth, it can be abused or used as a date-rape drug.
Drug for erectile dysfunction improves heart function in young heart-disease patients
Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.
Talking to ourselves: How consumers navigate choices and inner conflict
From simple decisions like "Should I eat this brownie?" to bigger questions such as "Should my next car be a hybrid?" consumers are involved in an inner dialogue that reflects thoughts and perspectives of their different selves, according to the authors of a new study in the Journal of Consumer Research.
Your Own Stem Cells Can Treat Heart Disease
The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn't receive stem cells.
The benefits of exercise
Physical exercise is one of the most effective methods of preventing disease. The current issue of Deutsches Arzteblatt International is devoted to this important topic.
Playing sport up to the end of pregnancy is healthy for the baby and the mother
Contrary to more conservative customs, exercising up to the end of pregnancy has no harmful effect on the weight or size of the foetus.
Texas Children's discharges first pediatric patient with implanted mechanical heart device
Texas Children's Hospital is the nation's first pediatric hospital to discharge a child while on an intracorporeal ventricular assist device (VAD), a feat previously accomplished only at adult institutions.
Expectant moms, babies subjects of new Singapore study to prevent obesity and diabetes in adults
Three Singapore biomedical institutions have launched a major, long-term study of pregnant mothers and their fetuses as well as infant children to determine just how profoundly environmental factors early in life influence the onset of diseases such as obesity and diabetes in later years.
DNA barcodes: Creative new uses span health, fraud, smuggling, history, more
The scientific ability to quickly and accurately identify species through DNA "barcoding" is being embraced and applied by a growing legion of global authorities - from medical and agricultural researchers to police and customs authorities to palaeontologists and others.
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