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Study confirms colonoscopy associated with reduced colorectal cancer incidence
October 03, 2008Patients who undergo a complete negative colonoscopy have a reduced incidence of colorectal cancer, confirms a study published in Clinical Gastroenterology and Hepatology. However, in the proximal colon, the incidence reduction of colorectal cancer following complete negative colonoscopy differs in magnitude and timing. The reduction of colorectal cancer is observed in about half of the 14 follow-up years and for the most part occurs after just seven years of follow-up. Clinical Gastroenterology and Hepatology is the official journal of the American Gastroenterological Association (AGA) Institute.
"Our study raises a question about the effectiveness of colonoscopy in usual clinical practice," said Linda Rabeneck, MD, MPH, of the University of Toronto and Institute for Clinical Evaluative Sciences in Toronto and lead author of the study. "Our findings suggest that the effectiveness of colonoscopy is reduced for cancers arising in the proximal colon. Whether this is due to colonoscopy quality, or whether it is due to tumor biology is the key issue that we need to address."
Findings
The relative rate of colorectal cancer overall and the relative rate of distal (left-sided) colorectal cancer in the study group remained significantly lower than the control population. The relative rate of proximal (right-sided) colorectal cancer was significantly lower than the control population in half of the follow-up years, mainly after seven years of follow-up.
Study Design
Using linked administrative databases, researchers identified a cohort of 110,402 Ontario residents aged 50 to 80 years old who had a negative complete colonoscopy between Jan. 1, 1992 and Dec. 31, 1997. Cohort members had no prior history of colorectal cancer, inflammatory bowel disease or recent colonic resection. Each individual was followed through Dec. 31, 2005 and the relative rate of overall colorectal cancer, distal colorectal cancer and proximal colorectal cancer was compared with the remaining Ontario population.
American Gastroenterological Association
The relative rate of colorectal cancer overall and the relative rate of distal (left-sided) colorectal cancer in the study group remained significantly lower than the control population. The relative rate of proximal (right-sided) colorectal cancer was significantly lower than the control population in half of the follow-up years, mainly after seven years of follow-up.
Study Design
Using linked administrative databases, researchers identified a cohort of 110,402 Ontario residents aged 50 to 80 years old who had a negative complete colonoscopy between Jan. 1, 1992 and Dec. 31, 1997. Cohort members had no prior history of colorectal cancer, inflammatory bowel disease or recent colonic resection. Each individual was followed through Dec. 31, 2005 and the relative rate of overall colorectal cancer, distal colorectal cancer and proximal colorectal cancer was compared with the remaining Ontario population.
American Gastroenterological Association
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The bowels of infection
Current research suggests that latent cytomegalovirus (CMV) infection may exacerbate inflammatory bowel disease (IBD). The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of The American Journal of Pathology.
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Adding cetuximab to chemotherapy reduces advanced lung cancer death risk by 13 percent
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New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
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University of Hawaii at Manoa CRCH scientists report adulthood body size associated with cancer risk
A team of scientists led by researcher Brenda Hernandez, Ph.D., M.P.H.-an assistant professor at the University of Hawai'i at Mānoa's Cancer Research Center of Hawai'i-has reported that body mass in younger and older adulthood, and weight gain between these life periods, may influence a man's risk for prostate cancer.
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