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Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
October 06, 2008
Novel platform technologies and key advances in genomics are rapidly driving the development of molecular diagnostics, reports Genetic Engineering and Biotechnology News (GEN). The payoff for successful molecular diagnostic products can be significant as Kalorama Information predicts that this market currently exceeds $3.2 billion worldwide and will reach $5.4 billion in four years, according to an article in the October 1 issue of GEN. "Molecular diagnostic products are based on cutting-edge research in two of the most promising biotechnologies, genomics and proteomics. These novel tests also utilize sophisticated analytical techniques such as microarrays and mass spectrometry," notes John Sterling, Editor-in-Chief of GEN. "Molecular diagnostics are particularly applicable to the early detection of cancer."
Affymetrix and Illumina have both created array-based products that enable high-speed analysis of DNA, RNA, and proteins as tools for disease research, drug development, and molecular tests. These gene-sequencing tools are being applied at an earlier stage.
Genetic tests can optimize drug therapy, and companion diagnostics are being touted as a method to better define a patient's need or predict clinical outcome from a specific drug. The FDA recently approved a HER-2 test from Invitrogen called Spot-Light that can be used to identify breast cancer patients who are candidates for treatment with Herceptin. In addition, data was recently presented showing the importance of testing for the K-ras gene to assess the clinical benefit of Erbitux for metastatic colorectal cancer.
Of all the larger integrated healthcare companies, Roche has best executed the synergies of molecular diagnostics and biopharmaceuticals and is well positioned for the future with products in oncology and infectious disease. Its genetic tests include CYP450 for drug metabolism studies and HER-2 for use with tamoxifen therapy.
Other companies covered in the GEN article include Myriad Genetics, Genomic Health, Genoptix, Luminex, Abbott Labs, Aureon, Autogenomics, Nanosphere, Navigenics, Osmetech, and Perlegen Sciences.
Mary Ann Liebert, Inc./Genetic Engineering News
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Molecular Diagnostics: Fundamentals, Methods, & Clinical Applications
by Lela (Author), Ph.D. Buckingham (Author), Maribeth L. (Author), Ph.D. Flaws (Author)
Lela Buckingham and Maribeth Flaws have developed the most comprehensive text available for the study of molecular diagnostics in the clinical laboratory setting. "Molecular Diagnostics" will give your students the background they need to understand the principles behind diagnostic tests that use molecular techniques. With its grounding in molecular biology and emphasis on the fluid nature of this topic as improved diagnostic technologies emerge, this text is the perfect balance between theory and application.
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Fundamentals of Molecular Diagnostics
by David E. Bruns MD (Author), Edward R. Ashwood MD (Author), Carl A. Burtis PhD (Author)
This book offers an introduction to the newest, fastest-growing field in laboratory science. Explaining and clarifying the molecular techniques used in diagnostic testing, this text provides both entry-level and advanced information. It covers the principles of molecular biology along with genomes and nucleic acid alterations, techniques and instrumentation, and applications of molecular diagnostics. Written by leading experts, this book includes illustrations, tables, and a colorful design to make information easy to find and easy to use.
A full-color, 4-page insert shows realistic images of the output for many molecular tests.Learning Objectives open each chapter with an overview of what you should achieve.Key Words are listed and defined at the beginning of each chapter, and are...
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Molecular Diagnostics: For the Clinical Laboratorian
by William B. Coleman (Editor), Gregory J. Tsongalis (Editor)
This updated and expanded tutorial guide to molecular diagnostic techniques takes advantage of many new molecular technologies to include both improved traditional methods and totally new methods, some not yet in routine use. The authors offer cutting-edge molecular diagnostics for genetic disease, human cancers, infectious diseases, and identity testing, as well as new insights into the question of quality assurance in the molecular diagnostics laboratory. Additional chapters address other technologies found in the clinical laboratory that complementary to molecular diagnostic technologies and discuss genetic counseling and the ethical and social issues involved with nucleic acid testing. A value-added compact disk containing a companion e-book version of the book, is included for...
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Molecular Diagnostics, Second Edition
by George Patrinos (Editor), Wilhelm Ansorge (Editor)
Key Features . Contains state-of-the-art techniques for the detection of the underlying genetic heterogeneity leading to inherited disorders . Includes in-depth discussion of ethical and safety considerations . Identifies genetically modified organisms (GMO's) . Covers forensic analysis and every-day issues in a diagnostic laboratory
Description The second edition of Molecular Diagnostics, the only book dealing with diagnosis on a molecular level, discusses current molecular biological techniques used to identify the underlying molecular defects in inherited disease. The book delves further into the principle and brief description of the technique, followed by examples from the authors' own expertise. Contributors to the 2/e are well-known experts in their...
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Molecular Diagnostics: Techniques and Applications for the Clinical Laboratory
by Wayne W. Grody (Editor), Robert M. Nakamura (Editor), Frederick L. Kiechle (Editor), Charles Strom (Editor)
Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. This handbook provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting.
* Serves as the definitivereference for molecular pathologists worldwide
* Covers a variety of molecular techniques including next generation...
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Molecular Diagnostic PCR Handbook
by Gerrit J. Viljoen (Editor), Louis H. Nel (Editor), John R. Crowther (Editor)
The uses of nucleic acid-directed methods have increased significantly in the past five years and have made important contributions to disease control country programmes for improving national and international trade. These developments include the more routine use of PCR as a diagnostic tool in veterinary diagnostic laboratories. There are, however, many problems associated with the transfer and particularly the application of this technology. These include a lack of consideration for the implementation and establishment of quality-assured procedures, the required set-up of the laboratory and the proper training of staff. This book gives a comprehensive account of the practical aspects of PCR and strong consideration is given to ensure its optimal use in a laboratory...
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Molecular Diagnostics: A Training and Study Guide
by Gregory J. Tsongalis (Author), William B. Coleman (Author)
"This study guide is aimed primarily at clinical laboratory scientists and those involved in the teaching or application of molecular diagnostics, an audience that includes medical students, physicians, and related professionals….Of particular value is chapter 3, 'Specimen Collection, Handling, Preparation and Processing'. This chapter provides detailed insight into practical aspects of molecular work often omitted from other texts. Chapter 7 is an excellent review of the molecular technologies available to the modern laboratory…. (T)his text does offer a comprehensive guide and will be of assistance to those seeking a firm foundation from which to exploit this rapidly expanding field. In their introduction, the authors state their intention to 'educate, train and promote the...
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Molecular Diagnostics: The Key Driver in Personalized Cancer Medicine
by Jan T Jorgensen (Editor), Henrik Winther (Editor)
This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. Journeying through definitions of the pharmacodiagnostic concept, the guide also explores historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics, and future aspects within personalized cancer medicine. The first of its kind to cover relevant subjects around molecular cancer diagnostics when used as important drivers in personalized cancer medicine, the book's different...
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Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (TIETZ TEXTBOOK OF CLINICAL CHEMISTRY ( BURTIS))
by Carl A. Burtis (Author), Edward R. Ashwood (Author), David E. Bruns (Author)
Bridging the gap between the clinical laboratory and medical management by relating pathophysiology to analytical results in health and disease, this classic resource provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Its up-to-date, encyclopedic coverage of the field defines analytical criteria for the medical usefulness of laboratory procedures, introduces new approaches for establishing reference ranges, describes variables that affect tests and results, examines modern analytical tools and their impact on lab management and costs, and demonstrates the applications of statistical methods.
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Cell and Tissue Based Molecular Pathology: A Volume in the Foundations in Diagnostic Pathology Series
by Raymond R. Tubbs DO (Author), Mark H. Stoler MD (Author)
This volume in the Foundations in Diagnostic Pathology Series packs today's most essential cell and tissue base molecular pathology into a compact, high-yield format! It focuses on the state of the art in practical validated molecular diagnostics as applied across the fields of surgical pathology and cytology. With an emphasis on current, clinically valid, and diagnostically important applications today and in the near future, you can be assured you're getting the most up-to-date, authoritative coverage available. Its pragmatic, well-organized approach, nearly 250 full-color illustrations, and at-a-glance boxes and tables make the information you need easy to access. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice!
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