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Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
October 06, 2008
Novel platform technologies and key advances in genomics are rapidly driving the development of molecular diagnostics, reports Genetic Engineering and Biotechnology News (GEN). The payoff for successful molecular diagnostic products can be significant as Kalorama Information predicts that this market currently exceeds $3.2 billion worldwide and will reach $5.4 billion in four years, according to an article in the October 1 issue of GEN. "Molecular diagnostic products are based on cutting-edge research in two of the most promising biotechnologies, genomics and proteomics. These novel tests also utilize sophisticated analytical techniques such as microarrays and mass spectrometry," notes John Sterling, Editor-in-Chief of GEN. "Molecular diagnostics are particularly applicable to the early detection of cancer."
Affymetrix and Illumina have both created array-based products that enable high-speed analysis of DNA, RNA, and proteins as tools for disease research, drug development, and molecular tests. These gene-sequencing tools are being applied at an earlier stage.
Genetic tests can optimize drug therapy, and companion diagnostics are being touted as a method to better define a patient's need or predict clinical outcome from a specific drug. The FDA recently approved a HER-2 test from Invitrogen called Spot-Light that can be used to identify breast cancer patients who are candidates for treatment with Herceptin. In addition, data was recently presented showing the importance of testing for the K-ras gene to assess the clinical benefit of Erbitux for metastatic colorectal cancer.
Of all the larger integrated healthcare companies, Roche has best executed the synergies of molecular diagnostics and biopharmaceuticals and is well positioned for the future with products in oncology and infectious disease. Its genetic tests include CYP450 for drug metabolism studies and HER-2 for use with tamoxifen therapy.
Other companies covered in the GEN article include Myriad Genetics, Genomic Health, Genoptix, Luminex, Abbott Labs, Aureon, Autogenomics, Nanosphere, Navigenics, Osmetech, and Perlegen Sciences.
Mary Ann Liebert, Inc./Genetic Engineering News
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Molecular Diagnostics: Fundamentals, Methods, & Clinical Applications
by Lela (Author), Ph.D. Buckingham (Author), Maribeth L. (Author), Ph.D. Flaws (Author)
Lela Buckingham and Maribeth Flaws have developed the most comprehensive text available for the study of molecular diagnostics in the clinical laboratory setting. "Molecular Diagnostics" will give your students the background they need to understand the principles behind diagnostic tests that use molecular techniques. With its grounding in molecular biology and emphasis on the fluid nature of this topic as improved diagnostic technologies emerge, this text is the perfect balance between theory and application.
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Fundamentals of Molecular Diagnostics
by David E. Bruns MD (Author), Edward R. Ashwood MD (Author), Carl A. Burtis PhD (Author)
This book offers an introduction to the newest, fastest-growing field in laboratory science. Explaining and clarifying the molecular techniques used in diagnostic testing, this text provides both entry-level and advanced information. It covers the principles of molecular biology along with genomes and nucleic acid alterations, techniques and instrumentation, and applications of molecular diagnostics. Written by leading experts, this book includes illustrations, tables, and a colorful design to make information easy to find and easy to use.
A full-color, 4-page insert shows realistic images of the output for many molecular tests.Learning Objectives open each chapter with an overview of what you should achieve.Key Words are listed and defined at the beginning of each chapter, and are...
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Molecular Diagnostics, Second Edition
by George Patrinos (Editor), Wilhelm Ansorge (Editor)
Key Features . Contains state-of-the-art techniques for the detection of the underlying genetic heterogeneity leading to inherited disorders . Includes in-depth discussion of ethical and safety considerations . Identifies genetically modified organisms (GMO's) . Covers forensic analysis and every-day issues in a diagnostic laboratory
Description The second edition of Molecular Diagnostics, the only book dealing with diagnosis on a molecular level, discusses current molecular biological techniques used to identify the underlying molecular defects in inherited disease. The book delves further into the principle and brief description of the technique, followed by examples from the authors' own expertise. Contributors to the 2/e are well-known experts in their...
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Molecular Diagnostics: For the Clinical Laboratorian
by William B. Coleman (Editor), Gregory J. Tsongalis (Editor)
This updated and expanded tutorial guide to molecular diagnostic techniques takes advantage of many new molecular technologies to include both improved traditional methods and totally new methods, some not yet in routine use. The authors offer cutting-edge molecular diagnostics for genetic disease, human cancers, infectious diseases, and identity testing, as well as new insights into the question of quality assurance in the molecular diagnostics laboratory. Additional chapters address other technologies found in the clinical laboratory that complementary to molecular diagnostic technologies and discuss genetic counseling and the ethical and social issues involved with nucleic acid testing. A value-added compact disk containing a companion e-book version of the book, is included for...
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Molecular Diagnostic PCR Handbook
by Gerrit J. Viljoen (Editor), Louis H. Nel (Editor), John R. Crowther (Editor)
The uses of nucleic acid-directed methods have increased significantly in the past five years and have made important contributions to disease control country programmes for improving national and international trade. These developments include the more routine use of PCR as a diagnostic tool in veterinary diagnostic laboratories. There are, however, many problems associated with the transfer and particularly the application of this technology. These include a lack of consideration for the implementation and establishment of quality-assured procedures, the required set-up of the laboratory and the proper training of staff. This book gives a comprehensive account of the practical aspects of PCR and strong consideration is given to ensure its optimal use in a laboratory...
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Diagnostic Pathology And Molecular Genetics Of The Thyroid A Comprehensive Guide For Practicing Thyroid Pathology
by Lippincott Williams & Wilkins
Diagnostic Pathology and Molecular Genetics of the Thyroid A Comprehensive Guide for Practicing Thyroid Pathology : Diagnostic Pathology and Molecular Genetics of the Thyroid A Comprehensive Guide for Practicing Thyroid Pathology Pub Date: February 2009 Product Type: Print Author/s: Yuri E Nikiforov MD, PhD; Paul W Biddinger MD; Lester D Thompson MD, FASCP, FCAP The first comprehensive surgical pathology textbook and reference on the thyroid in over fifteen years, this book presents the most advanced concepts on the diagnostic surgical pathology, cytopathology, immunohistochemistry, and molecular genetics of neoplastic and non-neoplastic thyroid diseases. The authors provide a detailed description of the surgical pathology of thyroid diseases side-by-side with major...
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Molecular Diagnostics: Current Technology and Applications (Horizon Bioscience)
by Juluri R. Rao (Author)
Molecular techniques are being harnessed for the detection of organisms in a wide range of circumstances. Global trade has introduced new pests of crops and plants; simultaneously, there is universal concern from disease outbreaks such as BSE, Foot & Mouth and the dreaded bird-flu virus. Molecular diagnostic applications for the detection of foodborne bacterial pathogens and genetically modified organisms in food are also becoming increasingly important.
This book provides a critical assessment of the various molecular methods in medical and veterinary science, forensics, biodefense, plant science, food safety and quarantine sciences. Aimed at a wide range of end-users encompassing postgraduates, postdoctoral research scientists, established researchers and specialist...
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Learn Medical Mycology Now Faster and Easier with Subliminal Programming CD
by Lavish-Life
The Superior Medical Mycology subliminal CD is designed to super charge your brain to learn medical mycology faster and easier than ever imagined. It will help you learn and master medical mycology so that you retain the material longer, understand it better, and enjoy it much more than you normally would. This session can help you pass medical mycology exams easier and with higher scores.
All you have to do is continue the same medical mycology classes or text that youre studying now and listen to this CD to accelerate your learning ability.
This CD contains 6 ten minute subliminal sessions to choose from. Each session contains the same subliminal suggestions carefully crafted by hypnotist Alex Armani, CHT. You get to choose which track(s) to listen to!
Successful people across the world...
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Molecular Diagnostics: Techniques and Applications for the Clinical Laboratory
by Wayne W. Grody (Editor), Robert M. Nakamura (Editor), Frederick L. Kiechle (Editor), Charles Strom (Editor)
Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. This handbook provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting.
* Serves as the definitivereference for molecular pathologists worldwide
* Covers a variety of molecular techniques including next generation...
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Molecular Diagnostics: A Training and Study Guide
by Gregory J. Tsongalis (Author), William B. Coleman (Author)
"This study guide is aimed primarily at clinical laboratory scientists and those involved in the teaching or application of molecular diagnostics, an audience that includes medical students, physicians, and related professionals….Of particular value is chapter 3, 'Specimen Collection, Handling, Preparation and Processing'. This chapter provides detailed insight into practical aspects of molecular work often omitted from other texts. Chapter 7 is an excellent review of the molecular technologies available to the modern laboratory…. (T)his text does offer a comprehensive guide and will be of assistance to those seeking a firm foundation from which to exploit this rapidly expanding field. In their introduction, the authors state their intention to 'educate, train and promote the...
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